increased b cell derived lymphoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal incidence of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes (Mammalian Phenotype Ontology, MP_0002023)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002023
Similar Terms
Downloads & Tools

Genes

48 gene mutations causing the increased b cell derived lymphoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
BAD BCL2-associated agonist of cell death
BCL2 B-cell CLL/lymphoma 2
BECN1 beclin 1, autophagy related
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
DKC1 dyskeratosis congenita 1, dyskerin
EAF2 ELL associated factor 2
FEN1 flap structure-specific endonuclease 1
FHIT fragile histidine triad
FLT3 fms-related tyrosine kinase 3
HMGA1 high mobility group AT-hook 1
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
ING1 inhibitor of growth family, member 1
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KMT2A lysine (K)-specific methyltransferase 2A
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLH1 mutL homolog 1
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA3 nuclear receptor coactivator 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLG polymerase (DNA directed), gamma
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SSBP2 single-stranded DNA binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
WWOX WW domain containing oxidoreductase