increased anxiety-related response Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests (Mammalian Phenotype Ontology, MP_0001363)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001363
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Genes

147 gene mutations causing the increased anxiety-related response phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ARX aristaless related homeobox
ATAT1 alpha tubulin acetyltransferase 1
ATF7 activating transcription factor 7
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BBS4 Bardet-Biedl syndrome 4
BDNF brain-derived neurotrophic factor
C12ORF10 chromosome 12 open reading frame 10
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CCKBR cholecystokinin B receptor
CER1 cerberus 1, DAN family BMP antagonist
CHD6 chromodomain helicase DNA binding protein 6
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPLX2 complexin 2
CREM cAMP responsive element modulator
CRHBP corticotropin releasing hormone binding protein
CRHR2 corticotropin releasing hormone receptor 2
CSMD1 CUB and Sushi multiple domains 1
CTNS cystinosin, lysosomal cystine transporter
DCDC2 doublecortin domain containing 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLG4 discs, large homolog 4 (Drosophila)
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
DRD1 dopamine receptor D1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EMC10 ER membrane protein complex subunit 10
EPM2AIP1 EPM2A (laforin) interacting protein 1
ESR2 estrogen receptor 2 (ER beta)
FABP7 fatty acid binding protein 7, brain
FEV FEV (ETS oncogene family)
FGFBP3 fibroblast growth factor binding protein 3
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSHR follicle stimulating hormone receptor
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GBX1 gastrulation brain homeobox 1
GJB6 gap junction protein, beta 6, 30kDa
GPR19 G protein-coupled receptor 19
GPR26 G protein-coupled receptor 26
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
GRM8 glutamate receptor, metabotropic 8
GRN granulin
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1
HDC histidine decarboxylase
HRH3 histamine receptor H3
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IDS iduronate 2-sulfatase
IDUA iduronidase, alpha-L-
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL6 interleukin 6
INS insulin
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KCNIP3 Kv channel interacting protein 3, calsenilin
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KIF13A kinesin family member 13A
L1CAM L1 cell adhesion molecule
LRP5 low density lipoprotein receptor-related protein 5
LRRC7 leucine rich repeat containing 7
LRRN1 leucine rich repeat neuronal 1
LRRTM1 leucine rich repeat transmembrane neuronal 1
LYPD1 LY6/PLAUR domain containing 1
MAP6 microtubule-associated protein 6
MAPT microtubule-associated protein tau
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDK midkine (neurite growth-promoting factor 2)
MECP2 methyl CpG binding protein 2
MPST mercaptopyruvate sulfurtransferase
MYO7A myosin VIIA
NAGLU N-acetylglucosaminidase, alpha
NENF neudesin neurotrophic factor
NLGN3 neuroligin 3
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS4 neuronal PAS domain protein 4
NPEPPS aminopeptidase puromycin sensitive
NPY neuropeptide Y
NTAN1 N-terminal asparagine amidase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPHN1 oligophrenin 1
OPRD1 opioid receptor, delta 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PENK proenkephalin
PITX3 paired-like homeodomain 3
PLAUR plasminogen activator, urokinase receptor
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RAI1 retinoic acid induced 1
RASD2 RASD family, member 2
RGS2 regulator of G-protein signaling 2
RIC8A RIC8 guanine nucleotide exchange factor A
RNF103 ring finger protein 103
S100A10 S100 calcium binding protein A10
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLITRK1 SLIT and NTRK-like family, member 1
SLITRK5 SLIT and NTRK-like family, member 5
SNAP25 synaptosomal-associated protein, 25kDa
SPPL3 signal peptide peptidase like 3
SPRED1 sprouty-related, EVH1 domain containing 1
SRR serine racemase
SSTR2 somatostatin receptor 2
SV2C synaptic vesicle glycoprotein 2C
TBX1 T-box 1
THRA thyroid hormone receptor, alpha
TMEM43 transmembrane protein 43
TNC tenascin C
TNF tumor necrosis factor
TPH2 tryptophan hydroxylase 2
TRHR thyrotropin-releasing hormone receptor
UCN urocortin
ULK2 unc-51 like autophagy activating kinase 2
VAMP7 vesicle-associated membrane protein 7
VIM vimentin
WFS1 Wolfram syndrome 1 (wolframin)