increased adenocarcinoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal incidence of a malignant neoplasm of epithelial cells in a glandular or glandular-like pattern (Mammalian Phenotype Ontology, MP_0009308)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009308
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Genes

90 gene mutations causing the increased adenocarcinoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ACPP acid phosphatase, prostate
ACTB actin, beta
APC adenomatous polyposis coli
ATAD5 ATPase family, AAA domain containing 5
AURKB aurora kinase B
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BECN1 beclin 1, autophagy related
BHLHA15 basic helix-loop-helix family, member a15
BIN3 bridging integrator 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CASC1 cancer susceptibility candidate 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCC DCC netrin 1 receptor
DKC1 dyskeratosis congenita 1, dyskerin
DNA2 DNA replication helicase/nuclease 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DOK3 docking protein 3
E2F1 E2F transcription factor 1
EAF2 ELL associated factor 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GON4L gon-4-like (C. elegans)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX7 glutathione peroxidase 7
HCK HCK proto-oncogene, Src family tyrosine kinase
HIC1 hypermethylated in cancer 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFNG interferon, gamma
IL10 interleukin 10
KRAS Kirsten rat sarcoma viral oncogene homolog
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LMO7 LIM domain 7
LTBP4 latent transforming growth factor beta binding protein 4
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSMB microseminoprotein, beta-
MUC2 mucin 2, oligomeric mucus/gel-forming
NBN nibrin
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PLK3 polo-like kinase 3
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPARD peroxisome proliferator-activated receptor delta
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRF1 perforin 1 (pore forming protein)
PTEN phosphatase and tensin homolog
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RINT1 RAD50 interactor 1
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A4 S100 calcium binding protein A4
SCRIB scribbled planar cell polarity protein
SMAD3 SMAD family member 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPX sushi-repeat containing protein, X-linked
SSBP2 single-stranded DNA binding protein 2
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TP73 tumor protein p73
TPX2 TPX2, microtubule-associated
TRIM62 tripartite motif containing 62
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C