increased acute inflammation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response (Mammalian Phenotype Ontology, MP_0005088)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005088
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Genes

115 gene mutations causing the increased acute inflammation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF2 activating transcription factor 2
BCR breakpoint cluster region
C3AR1 complement component 3a receptor 1
CASP12 caspase 12 (gene/pseudogene)
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CD44 CD44 molecule (Indian blood group)
CFH complement factor H
CISH cytokine inducible SH2-containing protein
CMKLR1 chemerin chemokine-like receptor 1
CPN1 carboxypeptidase N, polypeptide 1
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYBB cytochrome b-245, beta polypeptide
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F11R F11 receptor
FAS Fas cell surface death receptor
FBN1 fibrillin 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FES FES proto-oncogene, tyrosine kinase
FLG filaggrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GFI1 growth factor independent 1 transcription repressor
GPR34 G protein-coupled receptor 34
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HPGDS hematopoietic prostaglandin D synthase
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL10 interleukin 10
IL13 interleukin 13
IL1RN interleukin 1 receptor antagonist
IL20RB interleukin 20 receptor beta
IL22 interleukin 22
IL25 interleukin 25
IL27 interleukin 27
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
IRAK3 interleukin-1 receptor-associated kinase 3
JUND jun D proto-oncogene
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
LAT2 linker for activation of T cells family, member 2
LEP leptin
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR2 lysophosphatidic acid receptor 2
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MILR1 mast cell immunoglobulin-like receptor 1
MIR223 microRNA 223
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
NCF1 neutrophil cytosolic factor 1
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRC3 NLR family, CARD domain containing 3
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NTAN1 N-terminal asparagine amidase
OTC ornithine carbamoyltransferase
PARG poly (ADP-ribose) glycohydrolase
PCSK1 proprotein convertase subtilisin/kexin type 1
PIAS1 protein inhibitor of activated STAT, 1
PILRA paired immunoglobin-like type 2 receptor alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G2D phospholipase A2, group IID
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRKCD protein kinase C, delta
PTAFR platelet-activating factor receptor
PTGDR2 prostaglandin D2 receptor 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGES prostaglandin E synthase
PTGES2 prostaglandin E synthase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
RGS13 regulator of G-protein signaling 13
RGS3 regulator of G-protein signaling 3
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLPI secretory leukocyte peptidase inhibitor
SRXN1 sulfiredoxin 1
SSTR4 somatostatin receptor 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
TBK1 TANK-binding kinase 1
TBXA2R thromboxane A2 receptor
THBD thrombomodulin
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAFD1 TRAF-type zinc finger domain containing 1
TREML1 triggering receptor expressed on myeloid cells-like 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSC22D3 TSC22 domain family, member 3
USP18 ubiquitin specific peptidase 18
VIPR2 vasoactive intestinal peptide receptor 2