inactivation Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

346 proteins co-occuring with the biological term inactivation in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
ACLY ATP citrate lyase
ACO1 aconitase 1, soluble
ACP1 acid phosphatase 1, soluble
ADD1 adducin 1 (alpha)
ADRBK1 adrenergic, beta, receptor kinase 1
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHCYL1 adenosylhomocysteinase-like 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANXA2 annexin A2
AQP4 aquaporin 4
ARHGAP5 Rho GTPase activating protein 5
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATF1 activating transcription factor 1
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
AVPR2 arginine vasopressin receptor 2
BAD BCL2-associated agonist of cell death
BCAR1 breast cancer anti-estrogen resistance 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BMX BMX non-receptor tyrosine kinase
BRCA1 breast cancer 1, early onset
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CARD11 caspase recruitment domain family, member 11
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFL1 cofilin 1 (non-muscle)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHN2 chimerin 2
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CROCC ciliary rootlet coiled-coil, rootletin
CRTC2 CREB regulated transcription coactivator 2
CRYAB crystallin, alpha B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUEDC2 CUE domain containing 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYSLTR1 cysteinyl leukotriene receptor 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAP death-associated protein
DAPK1 death-associated protein kinase 1
DOK7 docking protein 7
DPYSL2 dihydropyrimidinase-like 2
DRD2 dopamine receptor D2
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP9 dual specificity phosphatase 9
DYNLL1 dynein, light chain, LC8-type 1
E2F1 E2F transcription factor 1
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF6 eukaryotic translation initiation factor 6
ELK1 ELK1, member of ETS oncogene family
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERF Ets2 repressor factor
ERN1 endoplasmic reticulum to nucleus signaling 1
ETV6 ets variant 6
EZR ezrin
F5 coagulation factor V (proaccelerin, labile factor)
FBXO4 F-box protein 4
FBXO43 F-box protein 43
FHIT fragile histidine triad
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA2 forkhead box A2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GJA1 gap junction protein, alpha 1, 43kDa
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GSN gelsolin
GTSE1 G-2 and S-phase expressed 1
GYS1 glycogen synthase 1 (muscle)
H2AFX H2A histone family, member X
H2AFY H2A histone family, member Y
H3F3A H3 histone, family 3A
HES1 hes family bHLH transcription factor 1
HIST1H3A histone cluster 1, H3a
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HORMAD1 HORMA domain containing 1
HORMAD2 HORMA domain containing 2
HSF1 heat shock transcription factor 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDR kinase insert domain receptor
KIF23 kinesin family member 23
KLF5 Kruppel-like factor 5 (intestinal)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT18 keratin 18, type I
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LPO lactoperoxidase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAPT microtubule-associated protein tau
MARK2 MAP/microtubule affinity-regulating kinase 2
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEF2D myocyte enhancer factor 2D
MET MET proto-oncogene, receptor tyrosine kinase
MKNK1 MAP kinase interacting serine/threonine kinase 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLXIPL MLX interacting protein-like
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSN moesin
MST1R macrophage stimulating 1 receptor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
MYL12B myosin, light chain 12B, regulatory
MYL9 myosin, light chain 9, regulatory
MYOG myogenin (myogenic factor 4)
NANOG Nanog homeobox
NBN nibrin
NCL nucleolin
NDC80 NDC80 kinetochore complex component
NDEL1 nudE neurodevelopment protein 1-like 1
NF2 neurofibromin 2 (merlin)
NFASC neurofascin
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NGFR nerve growth factor receptor
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUMA1 nuclear mitotic apparatus protein 1
OPRM1 opioid receptor, mu 1
PARD3 par-3 family cell polarity regulator
PARK2 parkin RBR E3 ubiquitin protein ligase
PAWR PRKC, apoptosis, WT1, regulator
PDCD10 programmed cell death 10
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4A phosphodiesterase 4A, cAMP-specific
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHB prohibitin
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PINK1 PTEN induced putative kinase 1
PKN1 protein kinase N1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PLN phospholamban
PML promyelocytic leukemia
PNKP polynucleotide kinase 3'-phosphatase
PNPT1 polyribonucleotide nucleotidyltransferase 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PRDX1 peroxiredoxin 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKD1 protein kinase D1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRA protein tyrosine phosphatase, receptor type, A
PTTG1 pituitary tumor-transforming 1
PXN paxillin
PYGL phosphorylase, glycogen, liver
RAD17 RAD17 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RDX radixin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGS4 regulator of G-protein signaling 4
RGS9 regulator of G-protein signaling 9
RHEB Ras homolog enriched in brain
RHOA ras homolog family member A
RHOQ ras homolog family member Q
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAS related RAS viral (r-ras) oncogene homolog
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SCG5 secretogranin V
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SETDB1 SET domain, bifurcated 1
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHCBP1 SHC SH2-domain binding protein 1
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMC1A structural maintenance of chromosomes 1A
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SOD2 superoxide dismutase 2, mitochondrial
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
STAR steroidogenic acute regulatory protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIP1 stress-induced phosphoprotein 1
STK24 serine/threonine kinase 24
STK4 serine/threonine kinase 4
STMN1 stathmin 1
STOML2 stomatin (EPB72)-like 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D4 TBC1 domain family, member 4
TCF3 transcription factor 3
TERT telomerase reverse transcriptase
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TH tyrosine hydroxylase
TLK1 tousled-like kinase 1
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TRIM28 tripartite motif containing 28
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TSSK3 testis-specific serine kinase 3
UBTF upstream binding transcription factor, RNA polymerase I
UNG uracil-DNA glycosylase
USF1 upstream transcription factor 1
USP1 ubiquitin specific peptidase 1
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VCL vinculin
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR77 WD repeat domain 77
WEE1 WEE1 G2 checkpoint kinase
WEE2 WEE1 homolog 2 (S. pombe)
YAP1 Yes-associated protein 1
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3HC1 zinc finger, C3HC-type containing 1
ZFP36 ZFP36 ring finger protein