impaired macrophage phagocytosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced ability of macrophage phagocytic cells to internalize particulate matter (Mammalian Phenotype Ontology, MP_0001798)
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37 gene mutations causing the impaired macrophage phagocytosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ANXA1 annexin A1
CAPG capping protein (actin filament), gelsolin-like
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD93 CD93 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLEC6A C-type lectin domain family 6, member A
CLIC4 chloride intracellular channel 4
CORO1A coronin, actin binding protein, 1A
FASLG Fas ligand (TNF superfamily, member 6)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
HCK HCK proto-oncogene, Src family tyrosine kinase
IER3 immediate early response 3
JMJD6 jumonji domain containing 6
LGALS3 lectin, galactoside-binding, soluble, 3
LTA lymphotoxin alpha
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCO macrophage receptor with collagenous structure
MFGE8 milk fat globule-EGF factor 8 protein
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCKAP1L NCK-associated protein 1-like
NOD2 nucleotide-binding oligomerization domain containing 2
PGAP3 post-GPI attachment to proteins 3
PLA2G5 phospholipase A2, group V
PTX3 pentraxin 3, long
RASA4 RAS p21 protein activator 4
SCARF1 scavenger receptor class F, member 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPIC Spi-C transcription factor (Spi-1/PU.1 related)
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TNF tumor necrosis factor
TRPV2 transient receptor potential cation channel, subfamily V, member 2