impaired granulosa cell differentiation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical production of or inability to produce the supporting cells for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle (Mammalian Phenotype Ontology, MP_0003357)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003357
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Genes

10 gene mutations causing the impaired granulosa cell differentiation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CSF1 colony stimulating factor 1 (macrophage)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
ZP2 zona pellucida glycoprotein 2 (sperm receptor)
ZP3 zona pellucida glycoprotein 3 (sperm receptor)