impaired contractility of urinary bladder detrusor smooth muscle Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description inability or reduced ability of the detrusor smooth muscle of the urinary bladder to shorten or to develop increased tension voluntarily or involuntarily; stretching of the smooth muscle fibers by accumulation of urine in the bladder leads to nervous signaling giving the urge to urinate; contraction of the detrusor muscle leads to urination, via emptying of the urine contained in the bladder through the urethra and urine excretion (Mammalian Phenotype Ontology, MP_0000741)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000741
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Genes

2 gene mutations causing the impaired contractility of urinary bladder detrusor smooth muscle phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CHRM3 cholinergic receptor, muscarinic 3
MYH11 myosin, heavy chain 11, smooth muscle