impaired acrosome reaction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced ability or inability to execute the cellular exocytosis of a single, anterior secretory granule following a sperm's attachment to the zona pellucida surrounding an oocyte (Mammalian Phenotype Ontology, MP_0004542)
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24 gene mutations causing the impaired acrosome reaction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY3 adenylate cyclase 3
APOB apolipoprotein B
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
CATSPER1 cation channel, sperm associated 1
CATSPER2 cation channel, sperm associated 2
CPLX1 complexin 1
CRISP1 cysteine-rich secretory protein 1
GLRA1 glycine receptor, alpha 1
GLRB glycine receptor, beta
KCNU1 potassium channel, subfamily U, member 1
MFGE8 milk fat globule-EGF factor 8 protein
NPC1 Niemann-Pick disease, type C1
OAZ3 ornithine decarboxylase antizyme 3
ODF1 outer dense fiber of sperm tails 1
PLCD4 phospholipase C, delta 4
PRND prion protein 2 (dublet)
PRNP prion protein
PRSS21 protease, serine, 21 (testisin)
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SMCP sperm mitochondria-associated cysteine-rich protein
TALDO1 transaldolase 1
TNP2 transition protein 2 (during histone to protamine replacement)