imipenem-2873 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the imipenem-2873 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ADAMTSL3 ADAMTS-like 3
AKT3 v-akt murine thymoma viral oncogene homolog 3
APLP1 amyloid beta (A4) precursor-like protein 1
ARID1A AT rich interactive domain 1A (SWI-like)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
C17ORF59 chromosome 17 open reading frame 59
C22ORF46 chromosome 22 open reading frame 46
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCDC7 coiled-coil domain containing 7
CD22 CD22 molecule
CD58 CD58 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CHRM2 cholinergic receptor, muscarinic 2
CRYM crystallin, mu
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTNS cystinosin, lysosomal cystine transporter
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DNAI2 dynein, axonemal, intermediate chain 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELMO1 engulfment and cell motility 1
EMID1 EMI domain containing 1
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERP44 endoplasmic reticulum protein 44
EVI5 ecotropic viral integration site 5
EXOSC1 exosome component 1
FBLN1 fibulin 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FGF20 fibroblast growth factor 20
FGFR1OP FGFR1 oncogene partner
FGFR4 fibroblast growth factor receptor 4
FRMPD1 FERM and PDZ domain containing 1
FXYD5 FXYD domain containing ion transport regulator 5
GPC3 glypican 3
GPR39 G protein-coupled receptor 39
GPR75 G protein-coupled receptor 75
GSTTP1 glutathione S-transferase theta pseudogene 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA10 homeobox A10
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ISL1 ISL LIM homeobox 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2C integral membrane protein 2C
JAG1 jagged 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLHL25 kelch-like family member 25
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MEF2D myocyte enhancer factor 2D
MIER2 mesoderm induction early response 1, family member 2
MRPL41 mitochondrial ribosomal protein L41
N4BP3 NEDD4 binding protein 3
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NNAT neuronatin
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
PCDH17 protocadherin 17
PDLIM4 PDZ and LIM domain 4
PHF20L1 PHD finger protein 20-like 1
PIDD1 p53-induced death domain protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PON3 paraoxonase 3
POU4F1 POU class 4 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RASA3 RAS p21 protein activator 3
RUNX1 runt-related transcription factor 1
SCN4A sodium channel, voltage gated, type IV alpha subunit
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLN sarcolipin
SOAT2 sterol O-acyltransferase 2
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPRED2 sprouty-related, EVH1 domain containing 2
SPTB spectrin, beta, erythrocytic
SRCAP Snf2-related CREBBP activator protein
STIM1 stromal interaction molecule 1
TDRD12 tudor domain containing 12
TEF thyrotrophic embryonic factor
TERT telomerase reverse transcriptase
TLDC1 TBC/LysM-associated domain containing 1
TM4SF1 transmembrane 4 L six family member 1
TMEM121 transmembrane protein 121
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TONSL tonsoku-like, DNA repair protein
VNN2 vanin 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZFP64 ZFP64 zinc finger protein
ZFPM2 zinc finger protein, FOG family member 2
ZMAT4 zinc finger, matrin-type 4
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANKRD40 ankyrin repeat domain 40
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
AXIN1 axin 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
C11ORF30 chromosome 11 open reading frame 30
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CBR1 carbonyl reductase 1
CCDC85C coiled-coil domain containing 85C
CDK3 cyclin-dependent kinase 3
CDK5 cyclin-dependent kinase 5
CIC capicua transcriptional repressor
CLCF1 cardiotrophin-like cytokine factor 1
CLCN2 chloride channel, voltage-sensitive 2
CNPY3 canopy FGF signaling regulator 3
CXORF56 chromosome X open reading frame 56
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNALI1 dynein, axonemal, light intermediate chain 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FBXO31 F-box protein 31
FBXW12 F-box and WD repeat domain containing 12
FFAR2 free fatty acid receptor 2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GCA grancalcin, EF-hand calcium binding protein
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLS2 glutaminase 2 (liver, mitochondrial)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HIST1H2AI histone cluster 1, H2ai
HIST1H3B histone cluster 1, H3b
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFT140 intraflagellar transport 140
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNK15 potassium channel, two pore domain subfamily K, member 15
KIF3A kinesin family member 3A
LARS leucyl-tRNA synthetase
LMNB1 lamin B1
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC37A2 leucine rich repeat containing 37, member A2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MBTD1 mbt domain containing 1
MCOLN1 mucolipin 1
METTL16 methyltransferase like 16
MGC12488
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NLRX1 NLR family member X1
NMU neuromedin U
NPIPB15 nuclear pore complex interacting protein family, member B15
NPIPB3 nuclear pore complex interacting protein family, member B3
NPY1R neuropeptide Y receptor Y1
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PCDHB13 protocadherin beta 13
PHF14 PHD finger protein 14
PLA2G10 phospholipase A2, group X
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PNPLA6 patatin-like phospholipase domain containing 6
POMT2 protein-O-mannosyltransferase 2
PRR4 proline rich 4 (lacrimal)
RBL1 retinoblastoma-like 1
RBM42 RNA binding motif protein 42
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RWDD3 RWD domain containing 3
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SPRYD7 SPRY domain containing 7
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STAG3 stromal antigen 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAOK1 TAO kinase 1
TBP TATA box binding protein
THOP1 thimet oligopeptidase 1
TLR2 toll-like receptor 2
TPCN1 two pore segment channel 1
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
VWA1 von Willebrand factor A domain containing 1
WDR33 WD repeat domain 33
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XYLT2 xylosyltransferase II
YIPF3 Yip1 domain family, member 3
YY2 YY2 transcription factor
ZBTB6 zinc finger and BTB domain containing 6
ZC3H3 zinc finger CCCH-type containing 3
ZNF273 zinc finger protein 273
ZNF324 zinc finger protein 324
ZNF329 zinc finger protein 329
ZNF37BP zinc finger protein 37B, pseudogene
ZNF480 zinc finger protein 480
ZNF573 zinc finger protein 573
ZNF639 zinc finger protein 639