iloprost-488 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the iloprost-488 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACTN1 actinin, alpha 1
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AGRN agrin
AP3D1 adaptor-related protein complex 3, delta 1 subunit
ARMC4 armadillo repeat containing 4
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP9A ATPase, class II, type 9A
BATF3 basic leucine zipper transcription factor, ATF-like 3
BRAP BRCA1 associated protein
CADM3 cell adhesion molecule 3
CAV3 caveolin 3
CCNT2 cyclin T2
CD2AP CD2-associated protein
CFAP70 cilia and flagella associated protein 70
CIITA class II, major histocompatibility complex, transactivator
COQ4 coenzyme Q4
COX15 cytochrome c oxidase assembly homolog 15 (yeast)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DUSP22 dual specificity phosphatase 22
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
EHD1 EH-domain containing 1
ENG endoglin
ENOX2 ecto-NOX disulfide-thiol exchanger 2
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPS8L1 EPS8-like 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP2 FK506 binding protein 2, 13kDa
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GOLM1 golgi membrane protein 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GSK3A glycogen synthase kinase 3 alpha
GTPBP4 GTP binding protein 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
INE1 inactivation escape 1 (non-protein coding)
KIF1C kinesin family member 1C
KLHL25 kelch-like family member 25
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00574 long intergenic non-protein coding RNA 574
LMO4 LIM domain only 4
LMTK2 lemur tyrosine kinase 2
LPPR2 lipid phosphate phosphatase-related protein type 2
LY6G6D lymphocyte antigen 6 complex, locus G6D
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MARK2 MAP/microtubule affinity-regulating kinase 2
MOB3B MOB kinase activator 3B
MVK mevalonate kinase
MYH10 myosin, heavy chain 10, non-muscle
NADK NAD kinase
NFYC nuclear transcription factor Y, gamma
NIPBL Nipped-B homolog (Drosophila)
PARVA parvin, alpha
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHIP pleckstrin homology domain interacting protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POU5F1B POU class 5 homeobox 1B
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PSG9 pregnancy specific beta-1-glycoprotein 9
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PTPRA protein tyrosine phosphatase, receptor type, A
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RBM41 RNA binding motif protein 41
RHO rhodopsin
RING1 ring finger protein 1
RITA1 RBPJ interacting and tubulin associated 1
RPS2 ribosomal protein S2
RUNX1 runt-related transcription factor 1
SH3BP2 SH3-domain binding protein 2
SIK3 SIK family kinase 3
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPG20 spastic paraplegia 20 (Troyer syndrome)
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TARBP1 TAR (HIV-1) RNA binding protein 1
TBRG4 transforming growth factor beta regulator 4
TCP11L1 t-complex 11, testis-specific-like 1
TET3 tet methylcytosine dioxygenase 3
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMPRSS5 transmembrane protease, serine 5
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSSC4 tumor suppressing subtransferable candidate 4
TYK2 tyrosine kinase 2
UBE3A ubiquitin protein ligase E3A
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WWTR1 WW domain containing transcription regulator 1
ZER1 zyg-11 related, cell cycle regulator
ZNF580 zinc finger protein 580

decreased expression

Symbol Name
ADM2 adrenomedullin 2
AMT aminomethyltransferase
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APCS amyloid P component, serum
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARSF arylsulfatase F
ATF7 activating transcription factor 7
AXIN1 axin 1
C6ORF47 chromosome 6 open reading frame 47
CCDC177 coiled-coil domain containing 177
CD70 CD70 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLCA1 chloride channel accessory 1
CNGB3 cyclic nucleotide gated channel beta 3
COPZ2 coatomer protein complex, subunit zeta 2
DAAM1 dishevelled associated activator of morphogenesis 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DIO3 deiodinase, iodothyronine, type III
DNASE1L2 deoxyribonuclease I-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EXOC6B exocyst complex component 6B
FAM76A family with sequence similarity 76, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOXC1 forkhead box C1
FRAS1 Fraser extracellular matrix complex subunit 1
GDF3 growth differentiation factor 3
GLMN glomulin, FKBP associated protein
GLRA2 glycine receptor, alpha 2
GMEB1 glucocorticoid modulatory element binding protein 1
GP9 glycoprotein IX (platelet)
GPR15 G protein-coupled receptor 15
GREB1L growth regulation by estrogen in breast cancer-like
GSTCD glutathione S-transferase, C-terminal domain containing
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HPGDS hematopoietic prostaglandin D synthase
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IL12RB1 interleukin 12 receptor, beta 1
JAM3 junctional adhesion molecule 3
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLF15 Kruppel-like factor 15
KLHL28 kelch-like family member 28
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR3 lysophosphatidic acid receptor 3
MAD2L1BP MAD2L1 binding protein
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAPK10 mitogen-activated protein kinase 10
MEFV Mediterranean fever
MIP major intrinsic protein of lens fiber
MOGAT2 monoacylglycerol O-acyltransferase 2
MT4 metallothionein 4
MTERF4 mitochondrial transcription termination factor 4
MUC2 mucin 2, oligomeric mucus/gel-forming
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPFFR1 neuropeptide FF receptor 1
NPY4R neuropeptide Y receptor Y4
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OVGP1 oviductal glycoprotein 1, 120kDa
PKD2L1 polycystic kidney disease 2-like 1
PRKCZ protein kinase C, zeta
PRODH2 proline dehydrogenase (oxidase) 2
PZP pregnancy-zone protein
RASL12 RAS-like, family 12
RHOH ras homolog family member H
RLBP1 retinaldehyde binding protein 1
RNF141 ring finger protein 141
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SQRDL sulfide quinone reductase-like (yeast)
SRPK3 SRSF protein kinase 3
STXBP5L syntaxin binding protein 5-like
SYNGR4 synaptogyrin 4
SYT2 synaptotagmin II
T T, brachyury homolog (mouse)
THBS4 thrombospondin 4
TMCC2 transmembrane and coiled-coil domain family 2
TMEM176A transmembrane protein 176A
TTTY15 testis-specific transcript, Y-linked 15 (non-protein coding)
TUBA3C tubulin, alpha 3c
TULP2 tubby like protein 2
USB1 U6 snRNA biogenesis 1
ZNF747 zinc finger protein 747