ikarugamycin-918 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the ikarugamycin-918 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOXL acyl-CoA oxidase-like
AGTR1 angiotensin II receptor, type 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARRB1 arrestin, beta 1
ASTN2 astrotactin 2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
C1ORF159 chromosome 1 open reading frame 159
CALD1 caldesmon 1
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLCF1 cardiotrophin-like cytokine factor 1
CLCN5 chloride channel, voltage-sensitive 5
CLDN1 claudin 1
COL10A1 collagen, type X, alpha 1
CSNK1G1 casein kinase 1, gamma 1
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CTBS chitobiase, di-N-acetyl-
CTIF CBP80/20-dependent translation initiation factor
CTSZ cathepsin Z
CYP2A7P1 cytochrome P450, family 2, subfamily A, polypeptide 7 pseudogene 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DPY19L1P1 DPY19L1 pseudogene 1
DUSP4 dual specificity phosphatase 4
EFCAB11 EF-hand calcium binding domain 11
EGR1 early growth response 1
ELL elongation factor RNA polymerase II
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
EXTL3 exostosin-like glycosyltransferase 3
FAM212B family with sequence similarity 212, member B
FLOT1 flotillin 1
FOXL1 forkhead box L1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GREB1L growth regulation by estrogen in breast cancer-like
GSPT1 G1 to S phase transition 1
HOXD13 homeobox D13
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUND jun D proto-oncogene
KLF6 Kruppel-like factor 6
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LHX2 LIM homeobox 2
LMO4 LIM domain only 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK14 mitogen-activated protein kinase 14
MBNL2 muscleblind-like splicing regulator 2
MED25 mediator complex subunit 25
MKL1 megakaryoblastic leukemia (translocation) 1
MVK mevalonate kinase
NCOA2 nuclear receptor coactivator 2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NLE1 notchless homolog 1 (Drosophila)
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRF1 nuclear respiratory factor 1
OR51E2 olfactory receptor, family 51, subfamily E, member 2
PAPOLB poly(A) polymerase beta (testis specific)
PARD6B par-6 family cell polarity regulator beta
PDE4DIP phosphodiesterase 4D interacting protein
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PRKD3 protein kinase D3
PRSS50 protease, serine, 50
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RPS2 ribosomal protein S2
RPS6 ribosomal protein S6
SCEL sciellin
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SIRT3 sirtuin 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STOM stomatin
STON1 stonin 1
SUGP1 SURP and G patch domain containing 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TAT tyrosine aminotransferase
TECPR2 tectonin beta-propeller repeat containing 2
TMC7 transmembrane channel-like 7
TMEM259 transmembrane protein 259
TNS2 tensin 2
TREX1 three prime repair exonuclease 1
TRIM23 tripartite motif containing 23
TRIM5 tripartite motif containing 5
TRIO trio Rho guanine nucleotide exchange factor
TSNAXIP1 translin-associated factor X interacting protein 1
TUBA3C tubulin, alpha 3c
WDR1 WD repeat domain 1
WWOX WW domain containing oxidoreductase
ZBTB33 zinc finger and BTB domain containing 33
ZCCHC24 zinc finger, CCHC domain containing 24
ZNF205 zinc finger protein 205
ZNF480 zinc finger protein 480
ZNF79 zinc finger protein 79
ZSCAN26 zinc finger and SCAN domain containing 26
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP13A2 ATPase type 13A2
BRPF1 bromodomain and PHD finger containing, 1
C10ORF88 chromosome 10 open reading frame 88
C5AR2 complement component 5a receptor 2
CCDC176 coiled-coil domain containing 176
CCDC85C coiled-coil domain containing 85C
CCNE1 cyclin E1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK20 cyclin-dependent kinase 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CIR1 corepressor interacting with RBPJ, 1
CISH cytokine inducible SH2-containing protein
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CRIP1 cysteine-rich protein 1 (intestinal)
DCAF10 DDB1 and CUL4 associated factor 10
DCLRE1A DNA cross-link repair 1A
DGAT1 diacylglycerol O-acyltransferase 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DMTN dematin actin binding protein
DTX4 deltex 4, E3 ubiquitin ligase
EFCAB2 EF-hand calcium binding domain 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERCC5 excision repair cross-complementation group 5
ETAA1 Ewing tumor-associated antigen 1
FAM160B2 family with sequence similarity 160, member B2
FURIN furin (paired basic amino acid cleaving enzyme)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
HDAC5 histone deacetylase 5
HIST1H2BJ histone cluster 1, H2bj
HMHA1 histocompatibility (minor) HA-1
HOXC10 homeobox C10
IL17RA interleukin 17 receptor A
IPP intracisternal A particle-promoted polypeptide
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIAA0894 KIAA0894 protein
LOC730101 uncharacterized LOC730101
MAN2C1 mannosidase, alpha, class 2C, member 1
MKNK1 MAP kinase interacting serine/threonine kinase 1
MORC4 MORC family CW-type zinc finger 4
MOSPD3 motile sperm domain containing 3
MRPS18C mitochondrial ribosomal protein S18C
NAG18 NAG18 mRNA
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NHLRC2 NHL repeat containing 2
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDZRN3 PDZ domain containing ring finger 3
PLA2G15 phospholipase A2, group XV
PLEKHA6 pleckstrin homology domain containing, family A member 6
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PRPH peripherin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
QTRT1 queuine tRNA-ribosyltransferase 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBM42 RNA binding motif protein 42
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RPGR retinitis pigmentosa GTPase regulator
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SH2B3 SH2B adaptor protein 3
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35F5 solute carrier family 35, member F5
SOAT1 sterol O-acyltransferase 1
SOX12 SRY (sex determining region Y)-box 12
SREK1IP1 SREK1-interacting protein 1
STRN4 striatin, calmodulin binding protein 4
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR91 WD repeat domain 91
ZBTB39 zinc finger and BTB domain containing 39
ZBTB48 zinc finger and BTB domain containing 48
ZNF160 zinc finger protein 160
ZNF250 zinc finger protein 250
ZNF254 zinc finger protein 254
ZNF34 zinc finger protein 34
ZNF430 zinc finger protein 430
ZNF721 zinc finger protein 721
ZNF76 zinc finger protein 76
ZNF778 zinc finger protein 778
ZNF91 zinc finger protein 91