ikappab kinase complex Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (Gene Ontology, GO_0008385)
External Link http://amigo.geneontology.org/amigo/term/GO:0008385
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Genes

10 proteins localized to the ikappab kinase complex cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
CHUK conserved helix-loop-helix ubiquitous kinase
ERC1 ELKS/RAB6-interacting/CAST family member 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP3K7 mitogen-activated protein kinase kinase kinase 7
PRDX3 peroxiredoxin 3
PYCARD PYD and CARD domain containing
PYDC1 PYD (pyrin domain) containing 1
TRIM40 tripartite motif containing 40