hypothalamus Gene Set

Dataset TISSUES Curated Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description The ventral part of the diencephalon that forms the floor and part of the lateral wall of the third ventricle. Anatomically, it includes the preoptic area, optic tract, optic chiasm, mammillary bodies, tuber cinereum, infundibulum, and neurohypophysis, but for physiological purposes the neurohypophysis is considered a distinct structure. The hypothalamus may be divided into five regions or areas (area hypothalamica rostralis, area hypothalamica dorsalis, area hypothalamica intermedia, area hypothalamica lateralis and area hypothalamica posterior) or into three longitudinal zones (periventricular zone, medial zone, and lateral zone). The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral autonomic mechanisms, endocrine activity, and many somatic functions, e.g., a general regulation of water balance, body temperature, sleep, and food intake, and the development of secondary sex characteristics. The hypothalamus secretes vasopressin and oxytocin, which are stored in the pituitary, as well as many releasing factors (hypophysiotropic hormones), by means of which it exerts control over functions of the adenohypophysis. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000614)
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Genes

113 proteins highly expressed in the tissue hypothalamus from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.

Symbol Name
ACOT13 acyl-CoA thioesterase 13
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
APLN apelin
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ARV1 ARV1 homolog (S. cerevisiae)
ASTE1 asteroid homolog 1 (Drosophila)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
ATXN10 ataxin 10
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BEX1 brain expressed, X-linked 1
C1ORF86 chromosome 1 open reading frame 86
CAB39 calcium binding protein 39
CCNDBP1 cyclin D-type binding-protein 1
CERS1 ceramide synthase 1
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHTOP chromatin target of PRMT1
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
COMMD5 COMM domain containing 5
COX11 COX11 cytochrome c oxidase copper chaperone
CRYL1 crystallin, lambda 1
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2
DPP10 dipeptidyl-peptidase 10 (non-functional)
ECHDC1 ethylmalonyl-CoA decarboxylase 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EMC7 ER membrane protein complex subunit 7
ENOPH1 enolase-phosphatase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
ESD esterase D
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
FBXL15 F-box and leucine-rich repeat protein 15
GABARAP GABA(A) receptor-associated protein
GPR61 G protein-coupled receptor 61
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HEPN1 hepatocellular carcinoma, down-regulated 1
HMP19 HMP19 protein
HP1BP3 heterochromatin protein 1, binding protein 3
HYI hydroxypyruvate isomerase (putative)
IFT80 intraflagellar transport 80
INO80C INO80 complex subunit C
INSIG2 insulin induced gene 2
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KISS1R KISS1 receptor
KIZ kizuna centrosomal protein
KLF12 Kruppel-like factor 12
KLHL2 kelch-like family member 2
LIMA1 LIM domain and actin binding 1
LRTM1 leucine-rich repeats and transmembrane domains 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MATR3 matrin 3
MFSD12 major facilitator superfamily domain containing 12
MRPL57 mitochondrial ribosomal protein L57
MSRA methionine sulfoxide reductase A
NADK NAD kinase
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NMB neuromedin B
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NXPH3 neurexophilin 3
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PCID2 PCI domain containing 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PEMT phosphatidylethanolamine N-methyltransferase
PGM1 phosphoglucomutase 1
PHC2 polyhomeotic homolog 2 (Drosophila)
PITHD1 PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1
PMCH pro-melanin-concentrating hormone
POGLUT1 protein O-glucosyltransferase 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDX2 peroxiredoxin 2
PRUNE2 prune homolog 2 (Drosophila)
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
RABAC1 Rab acceptor 1 (prenylated)
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RBM11 RNA binding motif protein 11
RCN3 reticulocalbin 3, EF-hand calcium binding domain
REPS2 RALBP1 associated Eps domain containing 2
RPL17 ribosomal protein L17
RPL19 ribosomal protein L19
RPP21 ribonuclease P/MRP 21kDa subunit
SAP18 Sin3A-associated protein, 18kDa
SCRN1 secernin 1
SCYL1 SCY1-like 1 (S. cerevisiae)
SIAE sialic acid acetylesterase
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC38A1 solute carrier family 38, member 1
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STOM stomatin
SULT4A1 sulfotransferase family 4A, member 1
TAGLN3 transgelin 3
TDRKH tudor and KH domain containing
TMEM126B transmembrane protein 126B
TMEM165 transmembrane protein 165
TMEM17 transmembrane protein 17
TMSB4Y thymosin beta 4, Y-linked
TPK1 thiamin pyrophosphokinase 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UCMA upper zone of growth plate and cartilage matrix associated
UIMC1 ubiquitin interaction motif containing 1
VTI1B vesicle transport through interaction with t-SNAREs 1B
WSB1 WD repeat and SOCS box containing 1
ZC3H15 zinc finger CCCH-type containing 15
ZFAND6 zinc finger, AN1-type domain 6