hypertensive heart disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A heart disease that is caused by high blood presure. (Human Disease Ontology, DOID_11516)
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Genes

95 genes co-occuring with the disease hypertensive heart disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 1.72775
ACE angiotensin I converting enzyme 1.6669
CTF1 cardiotrophin 1 1.54982
NPPA natriuretic peptide A 1.13501
PARM1 prostate androgen-regulated mucin-like protein 1 1.09209
RGS18 regulator of G-protein signaling 18 0.968761
MMP1 matrix metallopeptidase 1 0.962472
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.942443
NPPB natriuretic peptide B 0.929173
TBX18 T-box 18 0.888848
TBCD tubulin folding cofactor D 0.875738
APEH acylaminoacyl-peptide hydrolase 0.852402
HTN3 histatin 3 0.691896
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.679898
REN renin 0.626888
TCF21 transcription factor 21 0.624927
CPM carboxypeptidase M 0.623751
KNG1 kininogen 1 0.616312
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.606152
ADRA2C adrenoceptor alpha 2C 0.59913
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.594843
FBXO32 F-box protein 32 0.529222
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.52729
NPR1 natriuretic peptide receptor 1 0.516879
THBS4 thrombospondin 4 0.503824
SUMF1 sulfatase modifying factor 1 0.495029
CORIN corin, serine peptidase 0.488169
TIMP1 TIMP metallopeptidase inhibitor 1 0.482464
DCT dopachrome tautomerase 0.479047
FADS2 fatty acid desaturase 2 0.478289
PATE1 prostate and testis expressed 1 0.473361
DNM1 dynamin 1 0.464283
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.448817
BMP1 bone morphogenetic protein 1 0.447311
FBLN1 fibulin 1 0.446182
MMP9 matrix metallopeptidase 9 0.445805
GATA4 GATA binding protein 4 0.430768
ACR acrosin 0.426265
RING1 ring finger protein 1 0.403438
ADRA2A adrenoceptor alpha 2A 0.397098
CCL2 chemokine (C-C motif) ligand 2 0.379997
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.377773
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.37555
AOC2 amine oxidase, copper containing 2 (retina-specific) 0.372217
LIFR leukemia inhibitory factor receptor alpha 0.371477
ETV3 ets variant 3 0.363716
CDK11A cyclin-dependent kinase 11A 0.362239
MYEF2 myelin expression factor 2 0.357814
PPARA peroxisome proliferator-activated receptor alpha 0.352291
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 0.349717
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.342006
CTH cystathionine gamma-lyase 0.33651
IL6 interleukin 6 0.33651
MMP2 matrix metallopeptidase 2 0.333949
TARS threonyl-tRNA synthetase 0.328469
APLNR apelin receptor 0.326646
TGFB1 transforming growth factor, beta 1 0.316092
SPP1 secreted phosphoprotein 1 0.314278
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.305587
SRSF2 serine/arginine-rich splicing factor 2 0.304142
SMAD3 SMAD family member 3 0.290821
WIPF2 WAS/WASL interacting protein family, member 2 0.287593
TIMP4 TIMP metallopeptidase inhibitor 4 0.275089
CHRM3 cholinergic receptor, muscarinic 3 0.274732
ADRB1 adrenoceptor beta 1 0.261599
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.260891
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.260891
TNC tenascin C 0.257005
IGLV2-14 immunoglobulin lambda variable 2-14 0.252422
BANF1 barrier to autointegration factor 1 0.247852
SOCS1 suppressor of cytokine signaling 1 0.245747
KAT2B K(lysine) acetyltransferase 2B 0.243995
EFS embryonal Fyn-associated substrate 0.239101
CRP C-reactive protein, pentraxin-related 0.226262
GHSR growth hormone secretagogue receptor 0.220424
GPER1 G protein-coupled estrogen receptor 1 0.219057
ADCY2 adenylate cyclase 2 (brain) 0.213959
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.212608
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.209583
HDAC6 histone deacetylase 6 0.209248
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.207578
TCN2 transcobalamin II 0.200331
ERN1 endoplasmic reticulum to nucleus signaling 1 0.198386
FOS FBJ murine osteosarcoma viral oncogene homolog 0.187415
CTGF connective tissue growth factor 0.187113
ADORA1 adenosine A1 receptor 0.182375
ATF6 activating transcription factor 6 0.177576
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.176757
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.176215
C10ORF2 chromosome 10 open reading frame 2 0.175947
MAPK9 mitogen-activated protein kinase 9 0.174617
ESR2 estrogen receptor 2 (ER beta) 0.173571
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.172291
AOC3 amine oxidase, copper containing 3 0.168617
FUT2 fucosyltransferase 2 (secretor status included) 0.157929