hypersensitivity reaction type ii disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues. (Human Disease Ontology, DOID_417)
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Genes

272 genes associated with the disease hypersensitivity reaction type ii disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.31608
CFB complement factor B 2.21059
SLC44A4 solute carrier family 44, member 4 2.18152
LPP LIM domain containing preferred translocation partner in lipoma 2.04444
HLA-C major histocompatibility complex, class I, C 1.84115
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.50071
HLA-A major histocompatibility complex, class I, A 1.43901
ATXN2 ataxin 2 1.40682
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.37597
RAET1L retinoic acid early transcript 1L 1.37597
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 1.32252
OLIG3 oligodendrocyte transcription factor 3 1.30954
TYR tyrosinase 1.27521
ULBP3 UL16 binding protein 3 1.25088
RGS1 regulator of G-protein signaling 1 1.22898
CCR3 chemokine (C-C motif) receptor 3 1.2206
GPR19 G protein-coupled receptor 19 1.21385
TET3 tet methylcytosine dioxygenase 3 1.19506
TREH trehalase (brush-border membrane glycoprotein) 1.17894
RNASET2 ribonuclease T2 1.17894
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.14929
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.11998
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.09588
IL18RAP interleukin 18 receptor accessory protein 1.09588
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.09588
TAGAP T-cell activation RhoGTPase activating protein 1.06123
FAP fibroblast activation protein, alpha 1.04495
RERE arginine-glutamic acid dipeptide (RE) repeats 1.03485
IL21 interleukin 21 1.02486
DENND1B DENN/MADD domain containing 1B 1.00628
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.995303
PTPRK protein tyrosine phosphatase, receptor type, K 0.995303
SH2B3 SH2B adaptor protein 3 0.968307
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.965481
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.945428
FANCA Fanconi anemia, complementation group A 0.945428
IL18R1 interleukin 18 receptor 1 0.932337
EXOC3L4 exocyst complex component 3-like 4 0.932337
PUS10 pseudouridylate synthase 10 0.923046
KIAA1109 KIAA1109 0.894262
UHRF1BP1 UHRF1 binding protein 1 0.894262
CXCR5 chemokine (C-X-C motif) receptor 5 0.85991
CLEC16A C-type lectin domain family 16, member A 0.85991
MANBA mannosidase, beta A, lysosomal 0.850113
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.842276
LRRC18 leucine rich repeat containing 18 0.830123
IL12RB2 interleukin 12 receptor, beta 2 0.825265
DRAM1 DNA-damage regulated autophagy modulator 1 0.820928
CAPSL calcyphosine-like 0.817078
VWA7 von Willebrand factor A domain containing 7 0.817078
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.790827
NOTCH4 notch 4 0.790827
RAD51B RAD51 paralog B 0.790827
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.790827
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.774217
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.774217
PHF19 PHD finger protein 19 0.7623
ARID5B AT rich interactive domain 5B (MRF1-like) 0.752991
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.752991
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.724323
BLK BLK proto-oncogene, Src family tyrosine kinase 0.724323
PTTG1 pituitary tumor-transforming 1 0.724323
TNXB tenascin XB 0.69843
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.69843
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.69843
RUNX3 runt-related transcription factor 3 0.69843
TNPO3 transportin 3 0.682635
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.682635
ATF6B activating transcription factor 6 beta 0.682635
PHRF1 PHD and ring finger domains 1 0.682635
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.670996
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.670996
FKBPL FK506 binding protein like 0.670996
ADPRH ADP-ribosylarginine hydrolase 0.670996
FAM167A-AS1 FAM167A antisense RNA 1 0.670996
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.661797
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.661797
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.65413
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.65413
ZC3H7B zinc finger CCCH-type containing 7B 0.647573
ZMIZ1 zinc finger, MIZ-type containing 1 0.63666
LOC392787 filamin C pseudogene 0.63207
IL12A interleukin 12A 0.63207
RPL3 ribosomal protein L3 0.63207
UBASH3A ubiquitin associated and SH3 domain containing A 0.63207
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.602429
MICA MHC class I polypeptide-related sequence A 0.602429
ICOSLG inducible T-cell co-stimulator ligand 0.602429
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.602429
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.602429
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.602429
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.602429
CCR4 chemokine (C-C motif) receptor 4 0.58494
IL2RA interleukin 2 receptor, alpha 0.58494
MMEL1 membrane metallo-endopeptidase-like 1 0.58494
MUC21 mucin 21, cell surface associated 0.58494
C1ORF106 chromosome 1 open reading frame 106 0.572184
LYN LYN proto-oncogene, Src family tyrosine kinase 0.561725
TNIP1 TNFAIP3 interacting protein 1 0.561725
ATAT1 alpha tubulin acetyltransferase 1 0.561725
DPCR1 diffuse panbronchiolitis critical region 1 0.561725
ICOS inducible T-cell co-stimulator 0.552621
POU5F1 POU class 5 homeobox 1 0.552621
MICB MHC class I polypeptide-related sequence B 0.552621
PXK PX domain containing serine/threonine kinase 0.544585
PLEK pleckstrin 0.537125
ARHGAP31 Rho GTPase activating protein 31 0.537125
C6ORF15 chromosome 6 open reading frame 15 0.537125
AFF1 AF4/FMR2 family, member 1 0.537125
HLA-E major histocompatibility complex, class I, E 0.5306
TRIM15 tripartite motif containing 15 0.52461
TRIM31 tripartite motif containing 31 0.52461
ELF1 E74-like factor 1 (ets domain transcription factor) 0.52461
ERBB3 erb-b2 receptor tyrosine kinase 3 0.52461
RPP21 ribonuclease P/MRP 21kDa subunit 0.52461
LBH limb bud and heart development 0.52461
PRDM1 PR domain containing 1, with ZNF domain 0.486425
PLCL2 phospholipase C-like 2 0.486425
HLA-DOB major histocompatibility complex, class II, DO beta 0.486425
CREBL2 cAMP responsive element binding protein-like 2 0.486425
POU2AF1 POU class 2 associating factor 1 0.486425
SPRED2 sprouty-related, EVH1 domain containing 2 0.486425
HIP1 huntingtin interacting protein 1 0.486425
RPS26 ribosomal protein S26 0.486425
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.464771
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.464771
PRR14 proline rich 14 0.464771
RMI2 RecQ mediated genome instability 2 0.464771
TRIM26 tripartite motif containing 26 0.449873
HLA-G major histocompatibility complex, class I, G 0.449873
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.449873
IL7R interleukin 7 receptor 0.449873
IER3 immediate early response 3 0.449873
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.449873
NEU1 sialidase 1 (lysosomal sialidase) 0.449873
XCR1 chemokine (C motif) receptor 1 0.438544
ZC3H10 zinc finger CCCH-type containing 10 0.429338
BAG6 BCL2-associated athanogene 6 0.429338
TMSB4X thymosin beta 4, X-linked 0.429338
LRRC2 leucine rich repeat containing 2 0.429338
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.414708
CCDC88B coiled-coil domain containing 88B 0.414708
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.414708
SMOC2 SPARC related modular calcium binding 2 0.408752
TICAM1 toll-like receptor adaptor molecule 1 0.408752
PARK7 parkinson protein 7 0.408752
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.403461
LINC00208 long intergenic non-protein coding RNA 208 0.403461
EIF4E eukaryotic translation initiation factor 4E 0.403461
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.403461
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.403461
PRRC2A proline-rich coiled-coil 2A 0.403461
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.403461
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.403461
SOX5 SRY (sex determining region Y)-box 5 0.403461
NFIA nuclear factor I/A 0.403461
IL2 interleukin 2 0.403461
LTF lactotransferrin 0.403461
ATG5 autophagy related 5 0.403461
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.403461
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.403461
CD247 CD247 molecule 0.403461
PRRT1 proline-rich transmembrane protein 1 0.403461
CDH7 cadherin 7, type 2 0.368757
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.368757
BAD BCL2-associated agonist of cell death 0.368757
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.368757
PDHX pyruvate dehydrogenase complex, component X 0.368757
IKZF4 IKAROS family zinc finger 4 (Eos) 0.368757
ELMO1 engulfment and cell motility 1 0.368757
FRMD4B FERM domain containing 4B 0.368757
YDJC YdjC homolog (bacterial) 0.368757
STX17 syntaxin 17 0.368757
ICA1 islet cell autoantigen 1, 69kDa 0.368757
CDK2 cyclin-dependent kinase 2 0.368757
MYH15 myosin, heavy chain 15 0.345945
BRAP BRCA1 associated protein 0.345945
ANKRD55 ankyrin repeat domain 55 0.345945
ZNF689 zinc finger protein 689 0.345945
CCR2 chemokine (C-C motif) receptor 2 0.345945
MYNN myoneurin 0.345945
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.327313
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.327313
HSPA1L heat shock 70kDa protein 1-like 0.327313
JAZF1 JAZF zinc finger 1 0.327313
C6ORF25 chromosome 6 open reading frame 25 0.327313
HECA headcase homolog (Drosophila) 0.327313
PRDX5 peroxiredoxin 5 0.327313
APOM apolipoprotein M 0.311576
IRF5 interferon regulatory factor 5 0.311576
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.297866
LAMC2 laminin, gamma 2 0.297866
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.285417
RAB5B RAB5B, member RAS oncogene family 0.285417
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.285417
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.285417
FBXL20 F-box and leucine-rich repeat protein 20 0.274608
IFI16 interferon, gamma-inducible protein 16 0.274608
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.274608
LRRIQ4 leucine-rich repeats and IQ motif containing 4 0.264872
SOX6 SRY (sex determining region Y)-box 6 0.264872
ZNF639 zinc finger protein 639 0.256228
STAT4 signal transducer and activator of transcription 4 0.256228
PLXNA4 plexin A4 0.256228
GRB10 growth factor receptor-bound protein 10 0.256228
STK19 serine/threonine kinase 19 0.256228
RETNLB resistin like beta 0.256228
COL25A1 collagen, type XXV, alpha 1 0.256228
XPO1 exportin 1 0.256228
TTC34 tetratricopeptide repeat domain 34 0.256228
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.256228
DDA1 DET1 and DDB1 associated 1 0.256228
WNT3 wingless-type MMTV integration site family, member 3 0.256228
FYCO1 FYVE and coiled-coil domain containing 1 0.256228
LEF1 lymphoid enhancer-binding factor 1 0.197766
AJAP1 adherens junctions associated protein 1 0.197766
HUNK hormonally up-regulated Neu-associated kinase 0.197766
USP34 ubiquitin specific peptidase 34 0.197766
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.197766
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.197766
SCHIP1 schwannomin interacting protein 1 0.197766
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.197766
DCC DCC netrin 1 receptor 0.197766
IL13 interleukin 13 0.197766
ZNF385B zinc finger protein 385B 0.197766
WDFY4 WDFY family member 4 0.15771
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.15771
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.15771
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.15771
TG thyroglobulin 0.15771
CUX2 cut-like homeobox 2 0.15771
IL10 interleukin 10 0.15771
SUOX sulfite oxidase 0.15771
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.15771
NTNG2 netrin G2 0.15771
C6ORF99 chromosome 6 open reading frame 99 0.15771
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.126165
FOXP1 forkhead box P1 0.126165
GHR growth hormone receptor 0.126165
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.126165
ZFP36L1 ZFP36 ring finger protein-like 1 0.126165
ALPK2 alpha-kinase 2 0.126165
CCR6 chemokine (C-C motif) receptor 6 0.126165
C15ORF39 chromosome 15 open reading frame 39 0.126165
NCALD neurocalcin delta 0.126165
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.126165
IRF4 interferon regulatory factor 4 0.100789
CRH corticotropin releasing hormone 0.100789
AMY1A amylase, alpha 1A (salivary) 0.100789
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.100789
IL1RL1 interleukin 1 receptor-like 1 0.100789
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.100789
OSBPL8 oxysterol binding protein-like 8 0.100789
RASAL2 RAS protein activator like 2 0.100789
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 0.080593
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.080593
LYST lysosomal trafficking regulator 0.080593
CD274 CD274 molecule 0.080593
OR4A15 olfactory receptor, family 4, subfamily A, member 15 0.064973
NEGR1 neuronal growth regulator 1 0.064973
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.064973
SCN10A sodium channel, voltage gated, type X alpha subunit 0.064973
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.052255
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.052255
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.052255
SPANXN3 SPANX family, member N3 0.052255
TMC2 transmembrane channel-like 2 0.052255
CD80 CD80 molecule 0.052255
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.052255
CAMTA1 calmodulin binding transcription activator 1 0.043246
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.043246
NRXN1 neurexin 1 0.043246