hypersensitivity reaction disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An immune system disease that is caused by abnormal immune responses. (Human Disease Ontology, DOID_0060056)
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Genes

276 genes associated with the disease hypersensitivity reaction disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.31608
CFB complement factor B 2.21059
SLC44A4 solute carrier family 44, member 4 2.18152
LPP LIM domain containing preferred translocation partner in lipoma 2.04444
HLA-C major histocompatibility complex, class I, C 1.84115
IKZF1 IKAROS family zinc finger 1 (Ikaros) 1.50071
HLA-A major histocompatibility complex, class I, A 1.43901
ATXN2 ataxin 2 1.40682
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.37597
RAET1L retinoic acid early transcript 1L 1.37597
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 1.32252
OLIG3 oligodendrocyte transcription factor 3 1.30954
TYR tyrosinase 1.27521
CCDC88B coiled-coil domain containing 88B 1.26755
ULBP3 UL16 binding protein 3 1.25088
RGS1 regulator of G-protein signaling 1 1.22898
CCR3 chemokine (C-C motif) receptor 3 1.2206
GPR19 G protein-coupled receptor 19 1.21385
TET3 tet methylcytosine dioxygenase 3 1.19506
TREH trehalase (brush-border membrane glycoprotein) 1.17894
RNASET2 ribonuclease T2 1.17894
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.14929
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.11998
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.09588
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.09588
IL18RAP interleukin 18 receptor accessory protein 1.09588
TAGAP T-cell activation RhoGTPase activating protein 1.06123
FAP fibroblast activation protein, alpha 1.04495
RERE arginine-glutamic acid dipeptide (RE) repeats 1.03485
IL21 interleukin 21 1.02486
DENND1B DENN/MADD domain containing 1B 1.00628
PTPRK protein tyrosine phosphatase, receptor type, K 0.995303
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.995303
SH2B3 SH2B adaptor protein 3 0.968307
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.965481
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.945428
FANCA Fanconi anemia, complementation group A 0.945428
EXOC3L4 exocyst complex component 3-like 4 0.932337
IL18R1 interleukin 18 receptor 1 0.932337
PUS10 pseudouridylate synthase 10 0.923046
KIAA1109 KIAA1109 0.894262
UHRF1BP1 UHRF1 binding protein 1 0.894262
CLEC16A C-type lectin domain family 16, member A 0.85991
CXCR5 chemokine (C-X-C motif) receptor 5 0.85991
MANBA mannosidase, beta A, lysosomal 0.850113
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.842276
LRRC18 leucine rich repeat containing 18 0.830123
IL12RB2 interleukin 12 receptor, beta 2 0.825265
DRAM1 DNA-damage regulated autophagy modulator 1 0.820928
VWA7 von Willebrand factor A domain containing 7 0.817078
CAPSL calcyphosine-like 0.817078
NOTCH4 notch 4 0.790827
RAD51B RAD51 paralog B 0.790827
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.790827
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.790827
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.774217
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.774217
PHF19 PHD finger protein 19 0.7623
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.752991
ARID5B AT rich interactive domain 5B (MRF1-like) 0.752991
PTTG1 pituitary tumor-transforming 1 0.724323
BLK BLK proto-oncogene, Src family tyrosine kinase 0.724323
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.724323
TNXB tenascin XB 0.69843
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.69843
RUNX3 runt-related transcription factor 3 0.69843
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.69843
ATF6B activating transcription factor 6 beta 0.682635
PHRF1 PHD and ring finger domains 1 0.682635
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.682635
TNPO3 transportin 3 0.682635
FKBPL FK506 binding protein like 0.670996
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.670996
FAM167A-AS1 FAM167A antisense RNA 1 0.670996
ADPRH ADP-ribosylarginine hydrolase 0.670996
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.670996
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.661797
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.661797
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.65413
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.65413
ZC3H7B zinc finger CCCH-type containing 7B 0.647573
ZMIZ1 zinc finger, MIZ-type containing 1 0.63666
IL12A interleukin 12A 0.63207
UBASH3A ubiquitin associated and SH3 domain containing A 0.63207
RPL3 ribosomal protein L3 0.63207
LOC392787 filamin C pseudogene 0.63207
ICOSLG inducible T-cell co-stimulator ligand 0.602429
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.602429
MICA MHC class I polypeptide-related sequence A 0.602429
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.602429
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.602429
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.602429
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.602429
MUC21 mucin 21, cell surface associated 0.58494
CCR4 chemokine (C-C motif) receptor 4 0.58494
MMEL1 membrane metallo-endopeptidase-like 1 0.58494
IL2RA interleukin 2 receptor, alpha 0.58494
C1ORF106 chromosome 1 open reading frame 106 0.572184
LYN LYN proto-oncogene, Src family tyrosine kinase 0.561725
DPCR1 diffuse panbronchiolitis critical region 1 0.561725
TNIP1 TNFAIP3 interacting protein 1 0.561725
ATAT1 alpha tubulin acetyltransferase 1 0.561725
POU5F1 POU class 5 homeobox 1 0.552621
MICB MHC class I polypeptide-related sequence B 0.552621
ICOS inducible T-cell co-stimulator 0.552621
PXK PX domain containing serine/threonine kinase 0.544585
PLEK pleckstrin 0.537125
C6ORF15 chromosome 6 open reading frame 15 0.537125
ARHGAP31 Rho GTPase activating protein 31 0.537125
AFF1 AF4/FMR2 family, member 1 0.537125
HLA-E major histocompatibility complex, class I, E 0.5306
ERBB3 erb-b2 receptor tyrosine kinase 3 0.52461
TRIM31 tripartite motif containing 31 0.52461
ELF1 E74-like factor 1 (ets domain transcription factor) 0.52461
RPP21 ribonuclease P/MRP 21kDa subunit 0.52461
LBH limb bud and heart development 0.52461
TRIM15 tripartite motif containing 15 0.52461
SPRED2 sprouty-related, EVH1 domain containing 2 0.486425
CREBL2 cAMP responsive element binding protein-like 2 0.486425
PLCL2 phospholipase C-like 2 0.486425
PRDM1 PR domain containing 1, with ZNF domain 0.486425
HIP1 huntingtin interacting protein 1 0.486425
RPS26 ribosomal protein S26 0.486425
POU2AF1 POU class 2 associating factor 1 0.486425
HLA-DOB major histocompatibility complex, class II, DO beta 0.486425
RMI2 RecQ mediated genome instability 2 0.464771
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.464771
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.464771
PRR14 proline rich 14 0.464771
HLA-G major histocompatibility complex, class I, G 0.449873
NEU1 sialidase 1 (lysosomal sialidase) 0.449873
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.449873
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.449873
TRIM26 tripartite motif containing 26 0.449873
IER3 immediate early response 3 0.449873
IL7R interleukin 7 receptor 0.449873
XCR1 chemokine (C motif) receptor 1 0.438544
ZC3H10 zinc finger CCCH-type containing 10 0.429338
BAG6 BCL2-associated athanogene 6 0.429338
TMSB4X thymosin beta 4, X-linked 0.429338
LRRC2 leucine rich repeat containing 2 0.429338
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.414708
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.414708
TICAM1 toll-like receptor adaptor molecule 1 0.408752
PARK7 parkinson protein 7 0.408752
SMOC2 SPARC related modular calcium binding 2 0.408752
EIF4E eukaryotic translation initiation factor 4E 0.403461
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.403461
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.403461
LINC00208 long intergenic non-protein coding RNA 208 0.403461
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.403461
NFIA nuclear factor I/A 0.403461
CD247 CD247 molecule 0.403461
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.403461
IL2 interleukin 2 0.403461
PRRT1 proline-rich transmembrane protein 1 0.403461
LTF lactotransferrin 0.403461
SOX5 SRY (sex determining region Y)-box 5 0.403461
PRRC2A proline-rich coiled-coil 2A 0.403461
ATG5 autophagy related 5 0.403461
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.403461
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.403461
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.403461
ICA1 islet cell autoantigen 1, 69kDa 0.368757
STX17 syntaxin 17 0.368757
CDH7 cadherin 7, type 2 0.368757
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.368757
FRMD4B FERM domain containing 4B 0.368757
ELMO1 engulfment and cell motility 1 0.368757
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.368757
CDK2 cyclin-dependent kinase 2 0.368757
IKZF4 IKAROS family zinc finger 4 (Eos) 0.368757
PDHX pyruvate dehydrogenase complex, component X 0.368757
BAD BCL2-associated agonist of cell death 0.368757
YDJC YdjC homolog (bacterial) 0.368757
MYNN myoneurin 0.345945
CCR2 chemokine (C-C motif) receptor 2 0.345945
ANKRD55 ankyrin repeat domain 55 0.345945
ZNF689 zinc finger protein 689 0.345945
BRAP BRCA1 associated protein 0.345945
MYH15 myosin, heavy chain 15 0.345945
LY6G6C lymphocyte antigen 6 complex, locus G6C 0.327313
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.327313
HECA headcase homolog (Drosophila) 0.327313
JAZF1 JAZF zinc finger 1 0.327313
PRDX5 peroxiredoxin 5 0.327313
HSPA1L heat shock 70kDa protein 1-like 0.327313
C6ORF25 chromosome 6 open reading frame 25 0.327313
IRF5 interferon regulatory factor 5 0.311576
APOM apolipoprotein M 0.311576
LAMC2 laminin, gamma 2 0.297866
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.297866
UBE2L3 ubiquitin-conjugating enzyme E2L 3 0.285417
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.285417
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 0.285417
RAB5B RAB5B, member RAS oncogene family 0.285417
IFI16 interferon, gamma-inducible protein 16 0.274608
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 0.274608
FBXL20 F-box and leucine-rich repeat protein 20 0.274608
SOX6 SRY (sex determining region Y)-box 6 0.264872
LRRIQ4 leucine-rich repeats and IQ motif containing 4 0.264872
PLXNA4 plexin A4 0.256228
ANXA11 annexin A11 0.256228
ZNF639 zinc finger protein 639 0.256228
STK19 serine/threonine kinase 19 0.256228
DDA1 DET1 and DDB1 associated 1 0.256228
RETNLB resistin like beta 0.256228
COL25A1 collagen, type XXV, alpha 1 0.256228
FYCO1 FYVE and coiled-coil domain containing 1 0.256228
TTC34 tetratricopeptide repeat domain 34 0.256228
STAT4 signal transducer and activator of transcription 4 0.256228
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.256228
GRB10 growth factor receptor-bound protein 10 0.256228
XPO1 exportin 1 0.256228
WNT3 wingless-type MMTV integration site family, member 3 0.256228
SCHIP1 schwannomin interacting protein 1 0.197766
KCTD12 potassium channel tetramerization domain containing 12 0.197766
LEF1 lymphoid enhancer-binding factor 1 0.197766
HUNK hormonally up-regulated Neu-associated kinase 0.197766
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.197766
ZNF385B zinc finger protein 385B 0.197766
AJAP1 adherens junctions associated protein 1 0.197766
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.197766
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 0.197766
IL13 interleukin 13 0.197766
DCC DCC netrin 1 receptor 0.197766
USP34 ubiquitin specific peptidase 34 0.197766
C6ORF99 chromosome 6 open reading frame 99 0.15771
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 0.15771
SUOX sulfite oxidase 0.15771
TG thyroglobulin 0.15771
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.15771
IL10 interleukin 10 0.15771
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.15771
CUX2 cut-like homeobox 2 0.15771
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.15771
WDFY4 WDFY family member 4 0.15771
NTNG2 netrin G2 0.15771
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.126165
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.126165
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.126165
GRIK4 glutamate receptor, ionotropic, kainate 4 0.126165
FOXP1 forkhead box P1 0.126165
CCR6 chemokine (C-C motif) receptor 6 0.126165
ZFP36L1 ZFP36 ring finger protein-like 1 0.126165
NCALD neurocalcin delta 0.126165
C15ORF39 chromosome 15 open reading frame 39 0.126165
ALPK2 alpha-kinase 2 0.126165
GHR growth hormone receptor 0.126165
OSBPL8 oxysterol binding protein-like 8 0.100789
AMY1A amylase, alpha 1A (salivary) 0.100789
CRH corticotropin releasing hormone 0.100789
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.100789
RASAL2 RAS protein activator like 2 0.100789
IL1RL1 interleukin 1 receptor-like 1 0.100789
IRF4 interferon regulatory factor 4 0.100789
BANK1 B-cell scaffold protein with ankyrin repeats 1 0.100789
CD274 CD274 molecule 0.080593
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 0.080593
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.080593
LYST lysosomal trafficking regulator 0.080593
SCN10A sodium channel, voltage gated, type X alpha subunit 0.064973
OR4A15 olfactory receptor, family 4, subfamily A, member 15 0.064973
NEGR1 neuronal growth regulator 1 0.064973
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.064973
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.052255
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 0.052255
CD80 CD80 molecule 0.052255
SPANXN3 SPANX family, member N3 0.052255
TMC2 transmembrane channel-like 2 0.052255
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.052255
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.052255
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.043246
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.043246
NRXN1 neurexin 1 0.043246
CAMTA1 calmodulin binding transcription activator 1 0.043246