hyperplasia Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An abnormal increase in the number of cells in an organ or a tissue with consequent enlargement.|An abnormal increase in the number of (otherwise normal) cells in an organ or a tissue with consequent enlargement. (Experimental Factor Ontology, EFO_0000536)
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Genes

344 genes co-occuring with the biological term hyperplasia in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACHE acetylcholinesterase (Yt blood group)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
AEBP1 AE binding protein 1
AGTR1 angiotensin II receptor, type 1
AIM2 absent in melanoma 2
ALB albumin
AMACR alpha-methylacyl-CoA racemase
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANXA1 annexin A1
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
AR androgen receptor
AREG amphiregulin
ARMC5 armadillo repeat containing 5
ATOH7 atonal homolog 7 (Drosophila)
BAX BCL2-associated X protein
BCHE butyrylcholinesterase
BCL2 B-cell CLL/lymphoma 2
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
C1QA complement component 1, q subcomponent, A chain
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CALB2 calbindin 2
CASC3 cancer susceptibility candidate 3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCNE1 cyclin E1
CD24 CD24 molecule
CD34 CD34 molecule
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHGA chromogranin A
CHIT1 chitinase 1 (chitotriosidase)
CHRM3 cholinergic receptor, muscarinic 3
CLDN1 claudin 1
CLDN4 claudin 4
COL18A1 collagen, type XVIII, alpha 1
CREB1 cAMP responsive element binding protein 1
CRP C-reactive protein, pentraxin-related
CTCF CCCTC-binding factor (zinc finger protein)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYLD cylindromatosis (turban tumor syndrome)
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP21A1P cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYR61 cysteine-rich, angiogenic inducer, 61
DPYD dihydropyrimidine dehydrogenase
DSG1 desmoglein 1
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFNB2 ephrin-B2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPO erythropoietin
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM20A family with sequence similarity 20, member A
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FGF17 fibroblast growth factor 17
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGF7 fibroblast growth factor 7
FGF9 fibroblast growth factor 9
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FHIT fragile histidine triad
FHL5 four and a half LIM domains 5
FN1 fibronectin 1
FOXA2 forkhead box A2
FOXC2 forkhead box C2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
GAB2 GRB2-associated binding protein 2
GCG glucagon
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GNAS GNAS complex locus
GNRHR gonadotropin-releasing hormone receptor
GPC3 glypican 3
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HBEGF heparin-binding EGF-like growth factor
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSPA4 heat shock 70kDa protein 4
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP3 insulin-like growth factor binding protein 3
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL22RA1 interleukin 22 receptor, alpha 1
IL24 interleukin 24
IL25 interleukin 25
IL4 interleukin 4
IL9 interleukin 9
INHBA inhibin, beta A
INSL3 insulin-like 3 (Leydig cell)
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUP junction plakoglobin
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLF6 Kruppel-like factor 6
KLK15 kallikrein-related peptidase 15
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KLK7 kallikrein-related peptidase 7
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT7 keratin 7, type II
KRT75 keratin 75, type II
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LEP leptin
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGI1 leucine-rich, glioma inactivated 1
LHCGR luteinizing hormone/choriogonadotropin receptor
LIMS1 LIM and senescent cell antigen-like domains 1
LTBP1 latent transforming growth factor beta binding protein 1
MAPK8 mitogen-activated protein kinase 8
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEN1 multiple endocrine neoplasia I
MIR145 microRNA 145
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MT1A metallothionein 1A
MT2A metallothionein 2A
MT3 metallothionein 3
MTDH metadherin
MUC1 mucin 1, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
NCOR1 nuclear receptor corepressor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRCAM neuronal cell adhesion molecule
NTF4 neurotrophin 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUDC nudC nuclear distribution protein
OCLN occludin
OGG1 8-oxoguanine DNA glycosylase
OVGP1 oviductal glycoprotein 1, 120kDa
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAX2 paired box 2
PAX8 paired box 8
PCA3 prostate cancer associated 3 (non-protein coding)
PDE11A phosphodiesterase 11A
PDX1 pancreatic and duodenal homeobox 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POMC proopiomelanocortin
POR P450 (cytochrome) oxidoreductase
POU5F1 POU class 5 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PRKCA protein kinase C, alpha
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
PTK2 protein tyrosine kinase 2
PTTG1IP pituitary tumor-transforming 1 interacting protein
RARB retinoic acid receptor, beta
RARG retinoic acid receptor, gamma
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOD ras homolog family member D
RLN1 relaxin 1
RLN2 relaxin 2
RXRA retinoid X receptor, alpha
RXRG retinoid X receptor, gamma
S100A9 S100 calcium binding protein A9
SAA1 serum amyloid A1
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SELE selectin E
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SHBG sex hormone-binding globulin
SIM2 single-minded family bHLH transcription factor 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A4 solute carrier family 16, member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SMO smoothened, frizzled class receptor
SOD1 superoxide dismutase 1, soluble
SOX10 SRY (sex determining region Y)-box 10
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
STAR steroidogenic acute regulatory protein
STK11 serine/threonine kinase 11
STS steroid sulfatase (microsomal), isozyme S
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
TFF2 trefoil factor 2
TFF3 trefoil factor 3 (intestinal)
TFR2 transferrin receptor 2
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM4 transglutaminase 4
THBS1 thrombospondin 1
TMPRSS2 transmembrane protease, serine 2
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNXB tenascin XB
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPMT thiopurine S-methyltransferase
TTF1 transcription termination factor, RNA polymerase I
TUBA1B tubulin, alpha 1b
TUBB3 tubulin, beta 3 class III
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
TYRO3 TYRO3 protein tyrosine kinase
UMPS uridine monophosphate synthetase
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAT1 vesicle amine transport 1
VCAN versican
VCL vinculin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VGF VGF nerve growth factor inducible
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WISP2 WNT1 inducible signaling pathway protein 2
WNT7B wingless-type MMTV integration site family, member 7B
WWOX WW domain containing oxidoreductase
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase