hyperparathyroidism Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body. (Human Disease Ontology, DOID_13543)
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Genes

153 genes co-occuring with the disease hyperparathyroidism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PTH parathyroid hormone 4.72079
CASR calcium-sensing receptor 2.61704
ALPPL2 alkaline phosphatase, placental-like 2 2.47632
ALPP alkaline phosphatase, placental 2.47579
ALPL alkaline phosphatase, liver/bone/kidney 2.47474
MEN1 multiple endocrine neoplasia I 2.42634
CDC73 cell division cycle 73 2.14226
BGLAP bone gamma-carboxyglutamate (gla) protein 2.12418
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 2.07715
FGF23 fibroblast growth factor 23 2.03426
CALCA calcitonin-related polypeptide alpha 1.99595
RET ret proto-oncogene 1.87331
PTHLH parathyroid hormone-like hormone 1.68725
KNTC1 kinetochore associated 1 1.62112
GAST gastrin 1.50272
ALB albumin 1.49394
KL klotho 1.47418
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.31712
EMP1 epithelial membrane protein 1 1.27475
MGAM maltase-glucoamylase 1.20223
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.0753
GC group-specific component (vitamin D binding protein) 1.06774
ACPP acid phosphatase, prostate 1.04546
IGF1 insulin-like growth factor 1 (somatomedin C) 0.939119
INS insulin 0.919261
SPINK1 serine peptidase inhibitor, Kazal type 1 0.918848
CCND1 cyclin D1 0.866731
CTR9 CTR9, Paf1/RNA polymerase II complex component 0.865502
S100G S100 calcium binding protein G 0.854859
B2M beta-2-microglobulin 0.849945
SOST sclerostin 0.839296
XPO4 exportin 4 0.830689
CHGA chromogranin A 0.830279
TRPV5 transient receptor potential cation channel, subfamily V, member 5 0.822488
PPY pancreatic polypeptide 0.803616
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.790902
COL1A2 collagen, type I, alpha 2 0.77575
NPSR1 neuropeptide S receptor 1 0.770844
REN renin 0.769618
PTH1R parathyroid hormone 1 receptor 0.759416
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.743547
SST somatostatin 0.707559
FBN2 fibrillin 2 0.69751
AHSG alpha-2-HS-glycoprotein 0.662387
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.644586
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.632384
FTH1 ferritin, heavy polypeptide 1 0.62885
PHEX phosphate regulating endopeptidase homolog, X-linked 0.625711
GCM2 glial cells missing homolog 2 (Drosophila) 0.624143
GCG glucagon 0.616703
FTL ferritin, light polypeptide 0.613965
LRRC4C leucine rich repeat containing 4C 0.613574
WDR61 WD repeat domain 61 0.61162
FGF1 fibroblast growth factor 1 (acidic) 0.590558
PTH2 parathyroid hormone 2 0.574994
AKT1S1 AKT1 substrate 1 (proline-rich) 0.57305
PCNA proliferating cell nuclear antigen 0.532314
GHRH growth hormone releasing hormone 0.530768
ACE angiotensin I converting enzyme 0.521117
CRP C-reactive protein, pentraxin-related 0.502675
POMC proopiomelanocortin 0.493122
GNAS GNAS complex locus 0.490835
MGP matrix Gla protein 0.479047
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.463905
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.461639
EPO erythropoietin 0.457864
CARS cysteinyl-tRNA synthetase 0.42739
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.416896
SPTA1 spectrin, alpha, erythrocytic 1 0.413901
HRH2 histamine receptor H2 0.406051
PER1 period circadian clock 1 0.404184
CALB1 calbindin 1, 28kDa 0.395608
FLAD1 flavin adenine dinucleotide synthetase 1 0.395235
ZNF410 zinc finger protein 410 0.391885
TF transferrin 0.391513
BMP7 bone morphogenetic protein 7 0.384822
RNF115 ring finger protein 115 0.377031
FGFR1 fibroblast growth factor receptor 1 0.36741
GSAP gamma-secretase activating protein 0.364824
PER2 period circadian clock 2 0.35892
TG thyroglobulin 0.353027
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.347511
BSPRY B-box and SPRY domain containing 0.335412
TRH thyrotropin-releasing hormone 0.333949
IL6 interleukin 6 0.333583
DNAH8 dynein, axonemal, heavy chain 8 0.326281
ACP6 acid phosphatase 6, lysophosphatidic 0.312102
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 0.295492
IGFBP3 insulin-like growth factor binding protein 3 0.293694
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.289386
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.287952
PRL prolactin 0.287593
RTP2 receptor (chemosensory) transporter protein 2 0.276158
PHPT1 phosphohistidine phosphatase 1 0.271174
COPG1 coatomer protein complex, subunit gamma 1 0.260538
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.255946
ANKH ANKH inorganic pyrophosphate transport regulator 0.254536
AGXT alanine-glyoxylate aminotransferase 0.250663
MKI67 marker of proliferation Ki-67 0.24996
ANXA7 annexin A7 0.243645
LIN7A lin-7 homolog A (C. elegans) 0.238403
AVP arginine vasopressin 0.237009
CRTAC1 cartilage acidic protein 1 0.236312
SPP1 secreted phosphoprotein 1 0.235616
TBCA tubulin folding cofactor A 0.229716
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.228333
APEH acylaminoacyl-peptide hydrolase 0.227642
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.226607
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.21974
LRP2 low density lipoprotein receptor-related protein 2 0.219398
RNF20 ring finger protein 20, E3 ubiquitin protein ligase 0.215314
SCNN1D sodium channel, non voltage gated 1 delta subunit 0.213959
NF1 neurofibromin 1 0.213283
PTH2R parathyroid hormone 2 receptor 0.212608
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.212608
LEP leptin 0.203275
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 0.200982
NPPA natriuretic peptide A 0.17896
JUND jun D proto-oncogene 0.173832
ALK anaplastic lymphoma receptor tyrosine kinase 0.169812
ORAI2 ORAI calcium release-activated calcium modulator 2 0.168148
RGS8 regulator of G-protein signaling 8 0.163729
CABIN1 calcineurin binding protein 1 0.161139
CSDE1 cold shock domain containing E1, RNA-binding 0.157929
ALX1 ALX homeobox 1 0.147475
ACAA1 acetyl-CoA acyltransferase 1 0.141344
PRKCZ protein kinase C, zeta 0.141087
FRRS1L ferric-chelate reductase 1-like 0.140984
HIP1 huntingtin interacting protein 1 0.140976
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.140704
FBF1 Fas (TNFRSF6) binding factor 1 0.14061
PFDN5 prefoldin subunit 5 0.14061
SOX3 SRY (sex determining region Y)-box 3 0.140549
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.139915
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.139743
MED4 mediator complex subunit 4 0.139608
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 0.139481
TMEM51 transmembrane protein 51 0.139438
EPT1 ethanolaminephosphotransferase 1 0.139394
GLRX2 glutaredoxin 2 0.139284
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.139228
MN1 meningioma (disrupted in balanced translocation) 1 0.139206
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.137974
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.137849
ELF4 E74-like factor 4 (ets domain transcription factor) 0.137694
AIP aryl hydrocarbon receptor interacting protein 0.136152
SDF4 stromal cell derived factor 4 0.136135
MAN1A1 mannosidase, alpha, class 1A, member 1 0.136063
DTNBP1 dystrobrevin binding protein 1 0.135058
OAF OAF homolog (Drosophila) 0.134895
KCNK3 potassium channel, two pore domain subfamily K, member 3 0.134708
OASL 2'-5'-oligoadenylate synthetase-like 0.134623
PAX1 paired box 1 0.134408