hymecromone-4623 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the hymecromone-4623 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG1 adhesion G protein-coupled receptor G1
AGXT alanine-glyoxylate aminotransferase
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ARHGAP26 Rho GTPase activating protein 26
ARR3 arrestin 3, retinal (X-arrestin)
ARTN artemin
C10ORF12 chromosome 10 open reading frame 12
C9ORF9 chromosome 9 open reading frame 9
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CCL21 chemokine (C-C motif) ligand 21
CD7 CD7 molecule
CDK3 cyclin-dependent kinase 3
CELA2A chymotrypsin-like elastase family, member 2A
CLEC11A C-type lectin domain family 11, member A
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CRHR2 corticotropin releasing hormone receptor 2
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAI2 dynein, axonemal, intermediate chain 2
DPF3 D4, zinc and double PHD fingers, family 3
DVL3 dishevelled segment polarity protein 3
ELOVL5 ELOVL fatty acid elongase 5
EYA4 EYA transcriptional coactivator and phosphatase 4
F2RL2 coagulation factor II (thrombin) receptor-like 2
FABP3 fatty acid binding protein 3, muscle and heart
FGF18 fibroblast growth factor 18
FLRT2 fibronectin leucine rich transmembrane protein 2
FYB FYN binding protein
GAL galanin/GMAP prepropeptide
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAS7 growth arrest-specific 7
GKN1 gastrokine 1
GNMT glycine N-methyltransferase
GREB1 growth regulation by estrogen in breast cancer 1
GREB1L growth regulation by estrogen in breast cancer-like
GRIA3 glutamate receptor, ionotropic, AMPA 3
HAP1 huntingtin-associated protein 1
HES2 hes family bHLH transcription factor 2
HIC2 hypermethylated in cancer 2
HNMT histamine N-methyltransferase
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL11 interleukin 11
KANK3 KN motif and ankyrin repeat domains 3
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA1107 KIAA1107
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LOC100131510 uncharacterized LOC100131510
MASP2 mannan-binding lectin serine peptidase 2
MEG3 maternally expressed 3 (non-protein coding)
MILR1 mast cell immunoglobulin-like receptor 1
MUC4 mucin 4, cell surface associated
MVD mevalonate (diphospho) decarboxylase
MYL10 myosin, light chain 10, regulatory
NPY2R neuropeptide Y receptor Y2
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PCDH11Y protocadherin 11 Y-linked
PCDHGB5 protocadherin gamma subfamily B, 5
PDGFB platelet-derived growth factor beta polypeptide
PEX3 peroxisomal biogenesis factor 3
PHF20L1 PHD finger protein 20-like 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
POPDC2 popeye domain containing 2
PRKCA protein kinase C, alpha
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB26 RAB26, member RAS oncogene family
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S100A5 S100 calcium binding protein A5
SCN10A sodium channel, voltage gated, type X alpha subunit
SETD1A SET domain containing 1A
SGK2 serum/glucocorticoid regulated kinase 2
SIDT2 SID1 transmembrane family, member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SYCP2 synaptonemal complex protein 2
SYNDIG1 synapse differentiation inducing 1
TAGLN3 transgelin 3
TAPBP TAP binding protein (tapasin)
TBX1 T-box 1
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TTC30A tetratricopeptide repeat domain 30A
TTC9 tetratricopeptide repeat domain 9
TTLL5 tubulin tyrosine ligase-like family member 5
WIZ widely interspaced zinc finger motifs
ZFP2 ZFP2 zinc finger protein
ZNF358 zinc finger protein 358
ZNF440 zinc finger protein 440
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ARMC6 armadillo repeat containing 6
ARRB2 arrestin, beta 2
ASAP1-IT1 ASAP1 intronic transcript 1
ASTN1 astrotactin 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF30 chromosome 11 open reading frame 30
C16ORF62 chromosome 16 open reading frame 62
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CISH cytokine inducible SH2-containing protein
CLDN14 claudin 14
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNR2 cannabinoid receptor 2 (macrophage)
CPNE7 copine VII
CTSO cathepsin O
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DENND2D DENN/MADD domain containing 2D
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EFNA3 ephrin-A3
EGF epidermal growth factor
EHF ets homologous factor
ELP3 elongator acetyltransferase complex subunit 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA3 EYA transcriptional coactivator and phosphatase 3
FAT4 FAT atypical cadherin 4
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FILIP1L filamin A interacting protein 1-like
GPR176 G protein-coupled receptor 176
GPRASP1 G protein-coupled receptor associated sorting protein 1
GTF2I general transcription factor IIi
HIST1H1D histone cluster 1, H1d
HIST1H1T histone cluster 1, H1t
HIST1H2AM histone cluster 1, H2am
HIST1H2BJ histone cluster 1, H2bj
HOOK1 hook microtubule-tethering protein 1
IFT140 intraflagellar transport 140
IL15RA interleukin 15 receptor, alpha
IQSEC2 IQ motif and Sec7 domain 2
KDM5C lysine (K)-specific demethylase 5C
KIAA0754 KIAA0754
KIRREL kin of IRRE like (Drosophila)
KLF2 Kruppel-like factor 2
KRT20 keratin 20, type I
KRT33A keratin 33A, type I
LIG4 ligase IV, DNA, ATP-dependent
LMAN1 lectin, mannose-binding, 1
MAGEF1 melanoma antigen family F1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MRPL44 mitochondrial ribosomal protein L44
NOL12 nucleolar protein 12
NTF3 neurotrophin 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OLFM4 olfactomedin 4
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSMR oncostatin M receptor
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PALM paralemmin
PCOLCE procollagen C-endopeptidase enhancer
PCSK7 proprotein convertase subtilisin/kexin type 7
PDE8B phosphodiesterase 8B
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PER3 period circadian clock 3
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLAC8 placenta-specific 8
PLD3 phospholipase D family, member 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLXNB3 plexin B3
PWAR5 Prader Willi/Angelman region RNA 5
RAB27B RAB27B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGCC regulator of cell cycle
RGS17 regulator of G-protein signaling 17
RNF39 ring finger protein 39
RUSC2 RUN and SH3 domain containing 2
SYTL2 synaptotagmin-like 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TGFB3 transforming growth factor, beta 3
TMEM209 transmembrane protein 209
TSPAN2 tetraspanin 2
TUBB2B tubulin, beta 2B class IIb
WDR91 WD repeat domain 91
YY2 YY2 transcription factor
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF137P zinc finger protein 137, pseudogene
ZNF197 zinc finger protein 197
ZNF208 zinc finger protein 208
ZNF286A zinc finger protein 286A
ZSCAN2 zinc finger and SCAN domain containing 2