hydroxyzine-2024 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the hydroxyzine-2024 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABI2 abl-interactor 2
ADD1 adducin 1 (alpha)
AKAP7 A kinase (PRKA) anchor protein 7
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
APOC1 apolipoprotein C-I
AQP6 aquaporin 6, kidney specific
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARL1 ADP-ribosylation factor-like 1
ARRB2 arrestin, beta 2
ARSB arylsulfatase B
ASPH aspartate beta-hydroxylase
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BPIFA1 BPI fold containing family A, member 1
CAST calpastatin
CCPG1 cell cycle progression 1
CDHR2 cadherin-related family member 2
CEP131 centrosomal protein 131kDa
CHGB chromogranin B
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC4 chloride intracellular channel 4
CRELD1 cysteine-rich with EGF-like domains 1
CTRL chymotrypsin-like
CUL3 cullin 3
CUL4B cullin 4B
CXCL12 chemokine (C-X-C motif) ligand 12
CYB561 cytochrome b561
DBP D site of albumin promoter (albumin D-box) binding protein
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DUSP13 dual specificity phosphatase 13
ELMO2 engulfment and cell motility 2
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FAM189A2 family with sequence similarity 189, member A2
FAM64A family with sequence similarity 64, member A
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GLRA2 glycine receptor, alpha 2
GLUL glutamate-ammonia ligase
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HOOK2 hook microtubule-tethering protein 2
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQSEC2 IQ motif and Sec7 domain 2
KAT6B K(lysine) acetyltransferase 6B
KAT8 K(lysine) acetyltransferase 8
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LAMP1 lysosomal-associated membrane protein 1
LTB4R leukotriene B4 receptor
MAGOH2P mago-nashi homolog 2, pseudogene
MAGOHB mago-nashi homolog B (Drosophila)
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
METRN meteorin, glial cell differentiation regulator
MOB1A MOB kinase activator 1A
MYT1 myelin transcription factor 1
NT5M 5',3'-nucleotidase, mitochondrial
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAX1 paired box 1
PC pyruvate carboxylase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PECAM1 platelet/endothelial cell adhesion molecule 1
PEX14 peroxisomal biogenesis factor 14
PICALM phosphatidylinositol binding clathrin assembly protein
PKP3 plakophilin 3
PLD2 phospholipase D2
POFUT1 protein O-fucosyltransferase 1
RGS14 regulator of G-protein signaling 14
RIN3 Ras and Rab interactor 3
RNASE3 ribonuclease, RNase A family, 3
SCAMP1 secretory carrier membrane protein 1
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLMO2 slowmo homolog 2 (Drosophila)
SMA4 glucuronidase, beta pseudogene
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOS2 son of sevenless homolog 2 (Drosophila)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
STBD1 starch binding domain 1
TES testin LIM domain protein
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPR translocated promoter region, nuclear basket protein
UBQLN4 ubiquilin 4
USF2 upstream transcription factor 2, c-fos interacting
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR76 WD repeat domain 76
WNT10B wingless-type MMTV integration site family, member 10B
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZC3H7B zinc finger CCCH-type containing 7B
ZNF117 zinc finger protein 117
ZNF224 zinc finger protein 224
ZNF551 zinc finger protein 551
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABHD3 abhydrolase domain containing 3
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ASCC1 activating signal cointegrator 1 complex subunit 1
ATAD2B ATPase family, AAA domain containing 2B
ATXN2 ataxin 2
AVEN apoptosis, caspase activation inhibitor
BAG3 BCL2-associated athanogene 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCCIP BRCA2 and CDKN1A interacting protein
BCL7C B-cell CLL/lymphoma 7C
C10ORF2 chromosome 10 open reading frame 2
C12ORF29 chromosome 12 open reading frame 29
CAAP1 caspase activity and apoptosis inhibitor 1
CCDC6 coiled-coil domain containing 6
CCDC86 coiled-coil domain containing 86
CD320 CD320 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPOX coproporphyrinogen oxidase
CRYL1 crystallin, lambda 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXORF40A chromosome X open reading frame 40A
CYCS cytochrome c, somatic
CYTH2 cytohesin 2
DCAF6 DDB1 and CUL4 associated factor 6
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEAF1 DEAF1 transcription factor
DUSP12 dual specificity phosphatase 12
F13A1 coagulation factor XIII, A1 polypeptide
FAM136A family with sequence similarity 136, member A
FAM206A family with sequence similarity 206, member A
FANCF Fanconi anemia, complementation group F
FANCL Fanconi anemia, complementation group L
FBXL4 F-box and leucine-rich repeat protein 4
FTO fat mass and obesity associated
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GMEB1 glucocorticoid modulatory element binding protein 1
GPATCH2 G patch domain containing 2
GPN2 GPN-loop GTPase 2
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GSR glutathione reductase
GTPBP6 GTP binding protein 6 (putative)
HMGB3P1 high mobility group box 3 pseudogene 1
KIFC1 kinesin family member C1
LIMA1 LIM domain and actin binding 1
LZTR1 leucine-zipper-like transcription regulator 1
MCM10 minichromosome maintenance complex component 10
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRPL19 mitochondrial ribosomal protein L19
MRPL33 mitochondrial ribosomal protein L33
MTERF3 mitochondrial transcription termination factor 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NDEL1 nudE neurodevelopment protein 1-like 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NEK11 NIMA-related kinase 11
NFU1 NFU1 iron-sulfur cluster scaffold
NRBP1 nuclear receptor binding protein 1
NRIP3 nuclear receptor interacting protein 3
OVGP1 oviductal glycoprotein 1, 120kDa
PABPC3 poly(A) binding protein, cytoplasmic 3
PCNA proliferating cell nuclear antigen
PEMT phosphatidylethanolamine N-methyltransferase
PEPD peptidase D
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
POLI polymerase (DNA directed) iota
POTEKP POTE ankyrin domain family, member K, pseudogene
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAP1A RAP1A, member of RAS oncogene family
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RPS14P3 ribosomal protein S14 pseudogene 3
RPUSD2 RNA pseudouridylate synthase domain containing 2
SDHAF3 succinate dehydrogenase complex assembly factor 3
SMAD7 SMAD family member 7
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMNDC1 survival motor neuron domain containing 1
SP3 Sp3 transcription factor
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TCTN2 tectonic family member 2
TK1 thymidine kinase 1, soluble
TMPRSS6 transmembrane protease, serine 6
TRAPPC11 trafficking protein particle complex 11
TRIM26 tripartite motif containing 26
TRIM8 tripartite motif containing 8
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UNKL unkempt family zinc finger-like
UROS uroporphyrinogen III synthase
USB1 U6 snRNA biogenesis 1
WDR3 WD repeat domain 3
WDR82 WD repeat domain 82
WT1-AS WT1 antisense RNA
XBP1 X-box binding protein 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND3 zinc finger, AN1-type domain 3
ZNF14 zinc finger protein 14
ZNF32 zinc finger protein 32
ZNF652 zinc finger protein 652