hydroflumethiazide-7259 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the hydroflumethiazide-7259 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ADRBK1 adrenergic, beta, receptor kinase 1
AKR1C2 aldo-keto reductase family 1, member C2
ANKMY1 ankyrin repeat and MYND domain containing 1
BAX BCL2-associated X protein
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BRD4 bromodomain containing 4
BTN3A3 butyrophilin, subfamily 3, member A3
C10ORF88 chromosome 10 open reading frame 88
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CDC25C cell division cycle 25C
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CEP68 centrosomal protein 68kDa
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNPPD1 cyclin Pas1/PHO80 domain containing 1
CNTNAP2 contactin associated protein-like 2
COL6A1 collagen, type VI, alpha 1
COX15 cytochrome c oxidase assembly homolog 15 (yeast)
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ERGIC3 ERGIC and golgi 3
ESR1 estrogen receptor 1
F11R F11 receptor
FBN2 fibrillin 2
FLJ10038 uncharacterized protein FLJ10038
FLJ11292
GABARAPL1 GABA(A) receptor-associated protein like 1
GALK2 galactokinase 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL15RA interleukin 15 receptor, alpha
INCENP inner centromere protein antigens 135/155kDa
INO80B INO80 complex subunit B
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KLK10 kallikrein-related peptidase 10
KRIT1 KRIT1, ankyrin repeat containing
MAP2K2 mitogen-activated protein kinase kinase 2
MED16 mediator complex subunit 16
MITF microphthalmia-associated transcription factor
MMP13 matrix metallopeptidase 13
MYO1F myosin IF
NCOR2 nuclear receptor corepressor 2
NEK3 NIMA-related kinase 3
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NNMT nicotinamide N-methyltransferase
NOVA1 neuro-oncological ventral antigen 1
NRP1 neuropilin 1
NUMA1 nuclear mitotic apparatus protein 1
NUP62CL nucleoporin 62kDa C-terminal like
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PARP3 poly (ADP-ribose) polymerase family, member 3
PCOLCE procollagen C-endopeptidase enhancer
PEX7 peroxisomal biogenesis factor 7
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
RAB29 RAB29, member RAS oncogene family
RAD52 RAD52 homolog (S. cerevisiae)
RGS12 regulator of G-protein signaling 12
SCN1B sodium channel, voltage gated, type I beta subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD3 SERTA domain containing 3
SETD6 SET domain containing 6
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC12A9 solute carrier family 12, member 9
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPP1 secreted phosphoprotein 1
SRPX2 sushi-repeat containing protein, X-linked 2
SS18 synovial sarcoma translocation, chromosome 18
STK16 serine/threonine kinase 16
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SURF1 surfeit 1
TEAD3 TEA domain family member 3
TESK2 testis-specific kinase 2
TEX40 testis expressed 40
THAP3 THAP domain containing, apoptosis associated protein 3
TLE4 transducin-like enhancer of split 4
TMC5 transmembrane channel-like 5
TMEM212 transmembrane protein 212
TOX thymocyte selection-associated high mobility group box
TRIM23 tripartite motif containing 23
TRIO trio Rho guanine nucleotide exchange factor
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TXNRD2 thioredoxin reductase 2
VARS valyl-tRNA synthetase
WNT16 wingless-type MMTV integration site family, member 16
YTHDC2 YTH domain containing 2
ZBTB22 zinc finger and BTB domain containing 22
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZEB1 zinc finger E-box binding homeobox 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF224 zinc finger protein 224
ZNF84 zinc finger protein 84

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AP1AR adaptor-related protein complex 1 associated regulatory protein
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP3M2 adaptor-related protein complex 3, mu 2 subunit
BCAS3 breast carcinoma amplified sequence 3
BIRC3 baculoviral IAP repeat containing 3
C1R complement component 1, r subcomponent
C7ORF43 chromosome 7 open reading frame 43
C8ORF60 chromosome 8 open reading frame 60
C9ORF91 chromosome 9 open reading frame 91
CFD complement factor D (adipsin)
CLSPN claspin
CSRNP3 cysteine-serine-rich nuclear protein 3
CXORF56 chromosome X open reading frame 56
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DET1 de-etiolated homolog 1 (Arabidopsis)
DHRS11 dehydrogenase/reductase (SDR family) member 11
DLL3 delta-like 3 (Drosophila)
DTWD1 DTW domain containing 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYSF dysferlin
EFCAB2 EF-hand calcium binding domain 2
EN1 engrailed homeobox 1
EVL Enah/Vasp-like
FAM188A family with sequence similarity 188, member A
FSTL3 follistatin-like 3 (secreted glycoprotein)
FXN frataxin
GJC1 gap junction protein, gamma 1, 45kDa
GLCE glucuronic acid epimerase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GRPR gastrin-releasing peptide receptor
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HMHA1 histocompatibility (minor) HA-1
HSPB8 heat shock 22kDa protein 8
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JMJD4 jumonji domain containing 4
JUNB jun B proto-oncogene
KCTD20 potassium channel tetramerization domain containing 20
KIAA0556 KIAA0556
KPTN kaptin (actin binding protein)
KRT4 keratin 4, type II
LINC00339 long intergenic non-protein coding RNA 339
MTMR11 myotubularin related protein 11
MTRF1 mitochondrial translational release factor 1
NAG18 NAG18 mRNA
NDE1 nudE neurodevelopment protein 1
NECAP2 NECAP endocytosis associated 2
OCLN occludin
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PACS1 phosphofurin acidic cluster sorting protein 1
PALMD palmdelphin
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PARD6A par-6 family cell polarity regulator alpha
PDLIM2 PDZ and LIM domain 2 (mystique)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PTCD2 pentatricopeptide repeat domain 2
RAB11B RAB11B, member RAS oncogene family
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SDF2 stromal cell-derived factor 2
SESN1 sestrin 1
SH3BGR SH3 domain binding glutamate-rich protein
SIAH2 siah E3 ubiquitin protein ligase 2
SLC12A8 solute carrier family 12, member 8
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP140L SP140 nuclear body protein-like
SPEG SPEG complex locus
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STIM1 stromal interaction molecule 1
SUGCT succinyl-CoA:glutarate-CoA transferase
TBC1D19 TBC1 domain family, member 19
TESPA1 thymocyte expressed, positive selection associated 1
TMEM177 transmembrane protein 177
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAIP TRAF interacting protein
TRIM52 tripartite motif containing 52
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSPYL2 TSPY-like 2
TUBA3C tubulin, alpha 3c
USP27X ubiquitin specific peptidase 27, X-linked
WDR18 WD repeat domain 18
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
ZNF669 zinc finger protein 669
ZNF696 zinc finger protein 696
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862
ZSCAN31 zinc finger and SCAN domain containing 31