hydrocotarnine-6827 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the hydrocotarnine-6827 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADGRG1 adhesion G protein-coupled receptor G1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ARHGAP26 Rho GTPase activating protein 26
ARMCX4 armadillo repeat containing, X-linked 4
ARNT aryl hydrocarbon receptor nuclear translocator
ARSA arylsulfatase A
ART1 ADP-ribosyltransferase 1
ARTN artemin
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BST2 bone marrow stromal cell antigen 2
C14ORF1 chromosome 14 open reading frame 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALCB calcitonin-related polypeptide beta
CD58 CD58 molecule
CFAP69 cilia and flagella associated protein 69
CLCN4 chloride channel, voltage-sensitive 4
CRHR2 corticotropin releasing hormone receptor 2
CTSZ cathepsin Z
CXCR4 chemokine (C-X-C motif) receptor 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DMP1 dentin matrix acidic phosphoprotein 1
DOC2B double C2-like domains, beta
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EPHX2 epoxide hydrolase 2, cytoplasmic
ETNK2 ethanolamine kinase 2
FGF1 fibroblast growth factor 1 (acidic)
FKBP5 FK506 binding protein 5
FLOT1 flotillin 1
GNRH2 gonadotropin-releasing hormone 2
GREB1L growth regulation by estrogen in breast cancer-like
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HMOX1 heme oxygenase 1
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXA7 homeobox A7
HSPG2 heparan sulfate proteoglycan 2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IL9R interleukin 9 receptor
INSR insulin receptor
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGA7 integrin, alpha 7
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KAT6A K(lysine) acetyltransferase 6A
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLHDC8A kelch domain containing 8A
KRT9 keratin 9, type I
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMTK2 lemur tyrosine kinase 2
LRP12 low density lipoprotein receptor-related protein 12
LTC4S leukotriene C4 synthase
MAPK14 mitogen-activated protein kinase 14
MARK2 MAP/microtubule affinity-regulating kinase 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NF1 neurofibromin 1
NKX2-8 NK2 homeobox 8
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
PCDHA3 protocadherin alpha 3
PDE4DIP phosphodiesterase 4D interacting protein
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
POFUT1 protein O-fucosyltransferase 1
PON1 paraoxonase 1
PQLC2 PQ loop repeat containing 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RB1 retinoblastoma 1
RETN resistin
RGS4 regulator of G-protein signaling 4
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL7 ribosomal protein L7
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
RUNX1 runt-related transcription factor 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SIK3 SIK family kinase 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNN stannin
SNTA1 syntrophin, alpha 1
SP100 SP100 nuclear antigen
SP110 SP110 nuclear body protein
SPRED2 sprouty-related, EVH1 domain containing 2
SPRR1B small proline-rich protein 1B
SYNGR1 synaptogyrin 1
SYNJ1 synaptojanin 1
TAPBP TAP binding protein (tapasin)
TBR1 T-box, brain, 1
TCL1B T-cell leukemia/lymphoma 1B
TCP11L1 t-complex 11, testis-specific-like 1
TNS1 tensin 1
UBA7 ubiquitin-like modifier activating enzyme 7
USP46 ubiquitin specific peptidase 46
VPS9D1 VPS9 domain containing 1
ZNF528 zinc finger protein 528

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANP32A-IT1 ANP32A intronic transcript 1
APOD apolipoprotein D
ASB7 ankyrin repeat and SOCS box containing 7
ATP13A2 ATPase type 13A2
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
BCOR BCL6 corepressor
CAPRIN2 caprin family member 2
CBX7 chromobox homolog 7
CBX8 chromobox homolog 8
CD302 CD302 molecule
CEP97 centrosomal protein 97kDa
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLIP4 CAP-GLY domain containing linker protein family, member 4
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
DEAF1 DEAF1 transcription factor
DGKE diacylglycerol kinase, epsilon 64kDa
DMTN dematin actin binding protein
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13
DSPP dentin sialophosphoprotein
DVL1 dishevelled segment polarity protein 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EIF5A2 eukaryotic translation initiation factor 5A2
FAM110B family with sequence similarity 110, member B
FAM118A family with sequence similarity 118, member A
FAM169A family with sequence similarity 169, member A
FAM204A family with sequence similarity 204, member A
FBXW12 F-box and WD repeat domain containing 12
FKBP10 FK506 binding protein 10, 65 kDa
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTTP1 glutathione S-transferase theta pseudogene 1
GUSBP3 glucuronidase, beta pseudogene 3
HS1BP3 HCLS1 binding protein 3
IL20RA interleukin 20 receptor, alpha
IPP intracisternal A particle-promoted polypeptide
IQSEC2 IQ motif and Sec7 domain 2
KDM7A lysine (K)-specific demethylase 7A
KLHL25 kelch-like family member 25
LGALS4 lectin, galactoside-binding, soluble, 4
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAP1S microtubule-associated protein 1S
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MTCL1 microtubule crosslinking factor 1
MVP major vault protein
NDEL1 nudE neurodevelopment protein 1-like 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NHLRC2 NHL repeat containing 2
PAQR6 progestin and adipoQ receptor family member VI
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMM1 phosphomannomutase 1
POLL polymerase (DNA directed), lambda
PRF1 perforin 1 (pore forming protein)
PTPRE protein tyrosine phosphatase, receptor type, E
RAB33B RAB33B, member RAS oncogene family
RBL1 retinoblastoma-like 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RWDD3 RWD domain containing 3
SDC3 syndecan 3
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SOX12 SRY (sex determining region Y)-box 12
SSBP3 single stranded DNA binding protein 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STXBP2 syntaxin binding protein 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNGR3 synaptogyrin 3
TBX19 T-box 19
TESK1 testis-specific kinase 1
TLR5 toll-like receptor 5
TMEM104 transmembrane protein 104
TMEM110 transmembrane protein 110
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VGF VGF nerve growth factor inducible
WDR62 WD repeat domain 62
YEATS2 YEATS domain containing 2
YIPF3 Yip1 domain family, member 3
ZBTB3 zinc finger and BTB domain containing 3
ZNF141 zinc finger protein 141
ZNF280D zinc finger protein 280D
ZNF286A zinc finger protein 286A
ZNF516 zinc finger protein 516
ZNF747 zinc finger protein 747
ZNF778 zinc finger protein 778