hydrocotarnine-4489 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the hydrocotarnine-4489 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ADRBK2 adrenergic, beta, receptor kinase 2
AKAP6 A kinase (PRKA) anchor protein 6
ANGPTL2 angiopoietin-like 2
ANP32A-IT1 ANP32A intronic transcript 1
APAF1 apoptotic peptidase activating factor 1
ARL3 ADP-ribosylation factor-like 3
ARNT aryl hydrocarbon receptor nuclear translocator
ATM ATM serine/threonine kinase
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C1ORF61 chromosome 1 open reading frame 61
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD1A CD1a molecule
CD34 CD34 molecule
CDK13 cyclin-dependent kinase 13
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFLAR CASP8 and FADD-like apoptosis regulator
CLEC4E C-type lectin domain family 4, member E
CNTD2 cyclin N-terminal domain containing 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DMC1 DNA meiotic recombinase 1
DMP1 dentin matrix acidic phosphoprotein 1
DPYSL4 dihydropyrimidinase-like 4
EDAR ectodysplasin A receptor
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO11 F-box protein 11
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FUBP1 far upstream element (FUSE) binding protein 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLB1L galactosidase, beta 1-like
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
HCRP1 hepatocellular carcinoma-related HCRP1
HGFAC HGF activator
HHAT hedgehog acyltransferase
HIST1H4A histone cluster 1, H4a
HOMER3 homer scaffolding protein 3
HUS1 HUS1 checkpoint homolog (S. pombe)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL6 interleukin 6
INSL4 insulin-like 4 (placenta)
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIAA0319L KIAA0319-like
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KRT19P2 keratin 19 pseudogene 2
KRT32 keratin 32, type I
KRTAP9-9 keratin associated protein 9-9
LAPTM5 lysosomal protein transmembrane 5
LUZP4 leucine zipper protein 4
MAGEB2 melanoma antigen family B2
MCF2L MCF.2 cell line derived transforming sequence-like
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MORN1 MORN repeat containing 1
NCOR2 nuclear receptor corepressor 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRF1 nuclear respiratory factor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCDHGC3 protocadherin gamma subfamily C, 3
PDE4DIP phosphodiesterase 4D interacting protein
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRR protein tyrosine phosphatase, receptor type, R
RALYL RALY RNA binding protein-like
RANBP3 RAN binding protein 3
RGS5 regulator of G-protein signaling 5
RIN3 Ras and Rab interactor 3
SCGB2A2 secretoglobin, family 2A, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SEC14L5 SEC14-like 5 (S. cerevisiae)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
STOML1 stomatin (EPB72)-like 1
STRN3 striatin, calmodulin binding protein 3
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBX2 T-box 2
TCEAL2 transcription elongation factor A (SII)-like 2
TCP11L1 t-complex 11, testis-specific-like 1
TFEB transcription factor EB
TGFB1 transforming growth factor, beta 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC2 tuberous sclerosis 2
VAMP5 vesicle-associated membrane protein 5
WIZ widely interspaced zinc finger motifs
WWC1 WW and C2 domain containing 1
ZNF155 zinc finger protein 155
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ADCY6 adenylate cyclase 6
AMT aminomethyltransferase
ANXA2P1 annexin A2 pseudogene 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BAHCC1 BAH domain and coiled-coil containing 1
BFSP1 beaded filament structural protein 1, filensin
C14ORF93 chromosome 14 open reading frame 93
C17ORF70 chromosome 17 open reading frame 70
CCDC106 coiled-coil domain containing 106
CCDC9 coiled-coil domain containing 9
CCL27 chemokine (C-C motif) ligand 27
CLDN11 claudin 11
CORO1A coronin, actin binding protein, 1A
CRELD1 cysteine-rich with EGF-like domains 1
CSF1R colony stimulating factor 1 receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDN dendrin
DEAF1 DEAF1 transcription factor
DOC2A double C2-like domains, alpha
EFNA3 ephrin-A3
EGF epidermal growth factor
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM204A family with sequence similarity 204, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGL1 fibrinogen-like 1
FOXN2 forkhead box N2
GLS2 glutaminase 2 (liver, mitochondrial)
GNL1 guanine nucleotide binding protein-like 1
GPATCH3 G patch domain containing 3
GRAMD1C GRAM domain containing 1C
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H2AJ histone cluster 1, H2aj
HIST2H2AA3 histone cluster 2, H2aa3
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL12RB1 interleukin 12 receptor, beta 1
IL33 interleukin 33
IQCG IQ motif containing G
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPKA inositol-trisphosphate 3-kinase A
KIAA0513 KIAA0513
KIAA1549L KIAA1549-like
KRT31 keratin 31, type I
KRT86 keratin 86, type II
LMNB1 lamin B1
LRRC61 leucine rich repeat containing 61
LRRK1 leucine-rich repeat kinase 1
LTC4S leukotriene C4 synthase
LY86 lymphocyte antigen 86
MB myoglobin
METTL16 methyltransferase like 16
MFAP2 microfibrillar-associated protein 2
MFSD6 major facilitator superfamily domain containing 6
MILR1 mast cell immunoglobulin-like receptor 1
MMRN2 multimerin 2
MNX1 motor neuron and pancreas homeobox 1
MYOZ3 myozenin 3
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NKX3-2 NK3 homeobox 2
NRTN neurturin
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUP62CL nucleoporin 62kDa C-terminal like
PARM1 prostate androgen-regulated mucin-like protein 1
PICK1 protein interacting with PRKCA 1
PID1 phosphotyrosine interaction domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUNX1-IT1 RUNX1 intronic transcript 1
RWDD2A RWD domain containing 2A
SETBP1 SET binding protein 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC22A14 solute carrier family 22, member 14
SLC38A10 solute carrier family 38, member 10
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNPH syntaphilin
STAG3 stromal antigen 3
SYNGR3 synaptogyrin 3
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TEAD3 TEA domain family member 3
TMEM19 transmembrane protein 19
TMEM8B transmembrane protein 8B
TPCN1 two pore segment channel 1
TRAIP TRAF interacting protein
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC26 tetratricopeptide repeat domain 26
VN1R1 vomeronasal 1 receptor 1
ZC3H12A zinc finger CCCH-type containing 12A
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFHX2 zinc finger homeobox 2
ZNF197 zinc finger protein 197