hydrochlorothiazide-6625 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the hydrochlorothiazide-6625 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACPP acid phosphatase, prostate
ADAM23 ADAM metallopeptidase domain 23
ADORA1 adenosine A1 receptor
AMELY amelogenin, Y-linked
ARHGAP33 Rho GTPase activating protein 33
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCAP29 B-cell receptor-associated protein 29
BTG2 BTG family, member 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C2CD2L C2CD2-like
C8A complement component 8, alpha polypeptide
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCDC181 coiled-coil domain containing 181
CCL2 chemokine (C-C motif) ligand 2
CD22 CD22 molecule
CD58 CD58 molecule
CD80 CD80 molecule
CDC14A cell division cycle 14A
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEND1 cell cycle exit and neuronal differentiation 1
CES3 carboxylesterase 3
CLEC11A C-type lectin domain family 11, member A
CNTNAP2 contactin associated protein-like 2
COMMD4 COMM domain containing 4
CREBZF CREB/ATF bZIP transcription factor
CUL7 cullin 7
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAGLA diacylglycerol lipase, alpha
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNM3 dynamin 3
DSTYK dual serine/threonine and tyrosine protein kinase
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EPS8L1 EPS8-like 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXG1 forkhead box G1
FRMD4B FERM domain containing 4B
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLB1L galactosidase, beta 1-like
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL17RB interleukin 17 receptor B
IL22 interleukin 22
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIDINS220 kinase D-interacting substrate, 220kDa
KIF13A kinesin family member 13A
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAMB4 laminin, beta 4
LAT2 linker for activation of T cells family, member 2
LRRC37A3 leucine rich repeat containing 37, member A3
MAN1C1 mannosidase, alpha, class 1C, member 1
MBL2 mannose-binding lectin (protein C) 2, soluble
MECOM MDS1 and EVI1 complex locus
MMP3 matrix metallopeptidase 3
MUC4 mucin 4, cell surface associated
NF1 neurofibromin 1
NPAT nuclear protein, ataxia-telangiectasia locus
NPC1 Niemann-Pick disease, type C1
NPHP1 nephronophthisis 1 (juvenile)
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OR10H1 olfactory receptor, family 10, subfamily H, member 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PDE4DIP phosphodiesterase 4D interacting protein
PDPN podoplanin
POU5F1B POU class 5 homeobox 1B
PRKCE protein kinase C, epsilon
PVR poliovirus receptor
RAB6A RAB6A, member RAS oncogene family
RPL35A ribosomal protein L35a
RUNDC3B RUN domain containing 3B
SCN11A sodium channel, voltage gated, type XI alpha subunit
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERHL2 serine hydrolase-like 2
SLAMF7 SLAM family member 7
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC25A30 solute carrier family 25, member 30
SMO smoothened, frizzled class receptor
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBX1 T-box 1
TCP10 t-complex 10
TRIM29 tripartite motif containing 29
TRIM49 tripartite motif containing 49
UBA6 ubiquitin-like modifier activating enzyme 6
UBR2 ubiquitin protein ligase E3 component n-recognin 2
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WDR1 WD repeat domain 1
XDH xanthine dehydrogenase
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
AGO4 argonaute RISC catalytic component 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL14 ADP-ribosylation factor-like 14
BRAF B-Raf proto-oncogene, serine/threonine kinase
C3ORF52 chromosome 3 open reading frame 52
C9ORF40 chromosome 9 open reading frame 40
C9ORF9 chromosome 9 open reading frame 9
C9ORF91 chromosome 9 open reading frame 91
CCDC109B coiled-coil domain containing 109B
CD79B CD79b molecule, immunoglobulin-associated beta
CDON cell adhesion associated, oncogene regulated
CENPJ centromere protein J
CIR1 corepressor interacting with RBPJ, 1
CLEC2B C-type lectin domain family 2, member B
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CREB5 cAMP responsive element binding protein 5
CST1 cystatin SN
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYBRD1 cytochrome b reductase 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDN dendrin
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DLK2 delta-like 2 homolog (Drosophila)
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EPHA4 EPH receptor A4
EYA4 EYA transcriptional coactivator and phosphatase 4
FKTN fukutin
FOXC1 forkhead box C1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GMEB1 glucocorticoid modulatory element binding protein 1
GPATCH2L G patch domain containing 2-like
HAMP hepcidin antimicrobial peptide
HDAC5 histone deacetylase 5
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H3G histone cluster 1, H3g
HLX H2.0-like homeobox
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL2 interleukin 2
ITFG2 integrin alpha FG-GAP repeat containing 2
JMJD4 jumonji domain containing 4
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIRREL kin of IRRE like (Drosophila)
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LRRK1 leucine-rich repeat kinase 1
LYRM9 LYR motif containing 9
MAGEF1 melanoma antigen family F1
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MFGE8 milk fat globule-EGF factor 8 protein
MTERF1 mitochondrial transcription termination factor 1
MTMR6 myotubularin related protein 6
MUC3A mucin 3A, cell surface associated
NCS1 neuronal calcium sensor 1
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
OGFRL1 opioid growth factor receptor-like 1
OLFML2B olfactomedin-like 2B
ONECUT2 one cut homeobox 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PARM1 prostate androgen-regulated mucin-like protein 1
RARS arginyl-tRNA synthetase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RNF126P1 ring finger protein 126 pseudogene 1
RPL13P5 ribosomal protein L13 pseudogene 5
SCML1 sex comb on midleg-like 1 (Drosophila)
SESN1 sestrin 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLITRK5 SLIT and NTRK-like family, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAG3 stromal antigen 3
STON1 stonin 1
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TEX40 testis expressed 40
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM212 transmembrane protein 212
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
USP27X ubiquitin specific peptidase 27, X-linked
XYLT2 xylosyltransferase II
YOD1 YOD1 deubiquitinase
YPEL1 yippee-like 1 (Drosophila)
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF214 zinc finger protein 214
ZNF250 zinc finger protein 250
ZNF267 zinc finger protein 267
ZNF276 zinc finger protein 276
ZNF428 zinc finger protein 428
ZNF446 zinc finger protein 446
ZNF549 zinc finger protein 549
ZNF747 zinc finger protein 747