hydrastinine-2119 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the hydrastinine-2119 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APC adenomatous polyposis coli
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARMCX4 armadillo repeat containing, X-linked 4
ASAP1-IT1 ASAP1 intronic transcript 1
BST1 bone marrow stromal cell antigen 1
C16ORF59 chromosome 16 open reading frame 59
C1S complement component 1, s subcomponent
CABP5 calcium binding protein 5
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASZ1 castor zinc finger 1
CCL27 chemokine (C-C motif) ligand 27
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DSTYK dual serine/threonine and tyrosine protein kinase
EDA ectodysplasin A
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ESRRA estrogen-related receptor alpha
FCF1 FCF1 rRNA-processing protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS7 growth arrest-specific 7
GLB1L2 galactosidase, beta 1-like 2
GSK3A glycogen synthase kinase 3 alpha
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
INVS inversin
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
LMNA lamin A/C
LMNB1 lamin B1
LPAR3 lysophosphatidic acid receptor 3
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LYPD3 LY6/PLAUR domain containing 3
MAP1A microtubule-associated protein 1A
MAST2 microtubule associated serine/threonine kinase 2
METTL16 methyltransferase like 16
METTL5 methyltransferase like 5
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIIP migration and invasion inhibitory protein
MINK1 misshapen-like kinase 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MOCS1 molybdenum cofactor synthesis 1
MTSS1L metastasis suppressor 1-like
MVK mevalonate kinase
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NR2C1 nuclear receptor subfamily 2, group C, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRF1 nuclear respiratory factor 1
PALM paralemmin
PARVA parvin, alpha
PBX2 pre-B-cell leukemia homeobox 2
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PICALM phosphatidylinositol binding clathrin assembly protein
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PKP3 plakophilin 3
PLCG1 phospholipase C, gamma 1
PRKCA protein kinase C, alpha
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RANBP1 RAN binding protein 1
RARA retinoic acid receptor, alpha
RNF121 ring finger protein 121
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS4Y1 ribosomal protein S4, Y-linked 1
RTEL1 regulator of telomere elongation helicase 1
RUNX1 runt-related transcription factor 1
RUNX3 runt-related transcription factor 3
SETD1A SET domain containing 1A
SFT2D2 SFT2 domain containing 2
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLN sarcolipin
SOS2 son of sevenless homolog 2 (Drosophila)
STK16 serine/threonine kinase 16
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SUSD4 sushi domain containing 4
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBKBP1 TBK1 binding protein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TLE4 transducin-like enhancer of split 4
TREX1 three prime repair exonuclease 1
TRIM23 tripartite motif containing 23
TRIM25 tripartite motif containing 25
TSNAXIP1 translin-associated factor X interacting protein 1
TTC38 tetratricopeptide repeat domain 38
UBOX5 U-box domain containing 5
VGLL1 vestigial-like family member 1
YTHDC1 YTH domain containing 1
ZFHX3 zinc finger homeobox 3
ZFP69B ZFP69 zinc finger protein B
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ANGPTL4 angiopoietin-like 4
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
AP1AR adaptor-related protein complex 1 associated regulatory protein
ARHGAP11A Rho GTPase activating protein 11A
ARRB2 arrestin, beta 2
ATG9A autophagy related 9A
BGLAP bone gamma-carboxyglutamate (gla) protein
C1ORF105 chromosome 1 open reading frame 105
C5ORF30 chromosome 5 open reading frame 30
CABIN1 calcineurin binding protein 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CHMP6 charged multivesicular body protein 6
CLSPN claspin
CORO1A coronin, actin binding protein, 1A
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUTC cutC copper transporter
DCAF17 DDB1 and CUL4 associated factor 17
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEAF1 DEAF1 transcription factor
DFNB31 deafness, autosomal recessive 31
DMTF1 cyclin D binding myb-like transcription factor 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5A2 eukaryotic translation initiation factor 5A2
ERF Ets2 repressor factor
EVPL envoplakin
FKBP14 FK506 binding protein 14, 22 kDa
FLCN folliculin
FOXA1 forkhead box A1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLCE glucuronic acid epimerase
GLDC glycine dehydrogenase (decarboxylating)
GMCL1 germ cell-less, spermatogenesis associated 1
GUSBP3 glucuronidase, beta pseudogene 3
HAUS6 HAUS augmin-like complex, subunit 6
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIRA histone cell cycle regulator
HIST1H2AG histone cluster 1, H2ag
ICK intestinal cell (MAK-like) kinase
IFT22 intraflagellar transport 22
IL4R interleukin 4 receptor
KIF20B kinesin family member 20B
KIF3B kinesin family member 3B
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIAS lipoic acid synthetase
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRRC8E leucine rich repeat containing 8 family, member E
MANSC1 MANSC domain containing 1
MAST3 microtubule associated serine/threonine kinase 3
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED9 mediator complex subunit 9
MFSD11 major facilitator superfamily domain containing 11
MX1 MX dynamin-like GTPase 1
MYBBP1A MYB binding protein (P160) 1a
NABP2 nucleic acid binding protein 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PARP16 poly (ADP-ribose) polymerase family, member 16
PCYOX1 prenylcysteine oxidase 1
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHACTR4 phosphatase and actin regulator 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLQ polymerase (DNA directed), theta
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK7 protein tyrosine kinase 7 (inactive)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBL1 retinoblastoma-like 1
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
SFMBT1 Scm-like with four mbt domains 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A40 solute carrier family 25, member 40
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMA4 glucuronidase, beta pseudogene
SMG9 SMG9 nonsense mediated mRNA decay factor
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TLN1 talin 1
TOR4A torsin family 4, member A
TRIM16 tripartite motif containing 16
TRIM21 tripartite motif containing 21
TSPAN12 tetraspanin 12
UBQLN4 ubiquilin 4
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF107 zinc finger protein 107
ZNF254 zinc finger protein 254
ZNF408 zinc finger protein 408
ZNF430 zinc finger protein 430
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF767P zinc finger family member 767, pseudogene