hydralazine-3724 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hydralazine-3724 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AADAC arylacetamide deacetylase
ACAN aggrecan
ADGRA2 adhesion G protein-coupled receptor A2
AGFG2 ArfGAP with FG repeats 2
ALPPL2 alkaline phosphatase, placental-like 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
BBC3 BCL2 binding component 3
BTN3A1 butyrophilin, subfamily 3, member A1
BTN3A2 butyrophilin, subfamily 3, member A2
C14ORF1 chromosome 14 open reading frame 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CADM1 cell adhesion molecule 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CD1A CD1a molecule
CD2 CD2 molecule
CDK10 cyclin-dependent kinase 10
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN4 chloride channel, voltage-sensitive 4
CLEC4E C-type lectin domain family 4, member E
COL21A1 collagen, type XXI, alpha 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRHR2 corticotropin releasing hormone receptor 2
CXCR2 chemokine (C-X-C motif) receptor 2
CYBB cytochrome b-245, beta polypeptide
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22
DNAH17 dynein, axonemal, heavy chain 17
DRD5 dopamine receptor D5
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EDN1 endothelin 1
EGR1 early growth response 1
EVX1 even-skipped homeobox 1
FGF9 fibroblast growth factor 9
FKBP10 FK506 binding protein 10, 65 kDa
FLJ22184
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GFER growth factor, augmenter of liver regeneration
GJA4 gap junction protein, alpha 4, 37kDa
GPR19 G protein-coupled receptor 19
HEXIM1 hexamethylene bis-acetamide inducible 1
HSF1 heat shock transcription factor 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHA1 immunoglobulin heavy constant alpha 1
IL1RN interleukin 1 receptor antagonist
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LOC100294391 uncharacterized LOC100294391
LTBP4 latent transforming growth factor beta binding protein 4
MAP7D3 MAP7 domain containing 3
MECOM MDS1 and EVI1 complex locus
MEGF6 multiple EGF-like-domains 6
MIER2 mesoderm induction early response 1, family member 2
MMP7 matrix metallopeptidase 7
MST1 macrophage stimulating 1
MVD mevalonate (diphospho) decarboxylase
NEUROD6 neuronal differentiation 6
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NTF3 neurotrophin 3
PCDH9 protocadherin 9
PDE4D phosphodiesterase 4D, cAMP-specific
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCL2 phospholipase C-like 2
PLXND1 plexin D1
PRB1 proline-rich protein BstNI subfamily 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PROX1 prospero homeobox 1
PTN pleiotrophin
PTPRJ protein tyrosine phosphatase, receptor type, J
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RANBP3 RAN binding protein 3
RECQL5 RecQ protein-like 5
RIMS2 regulating synaptic membrane exocytosis 2
RNF2 ring finger protein 2
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SH3GL3 SH3-domain GRB2-like 3
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SRSF7 serine/arginine-rich splicing factor 7
SSX3 synovial sarcoma, X breakpoint 3
STMN4 stathmin-like 4
SYCE1L synaptonemal complex central element protein 1-like
SYT5 synaptotagmin V
TAS2R1 taste receptor, type 2, member 1
TBRG4 transforming growth factor beta regulator 4
TBX1 T-box 1
TBX19 T-box 19
TCF3 transcription factor 3
TET3 tet methylcytosine dioxygenase 3
TFR2 transferrin receptor 2
TLR1 toll-like receptor 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WIZ widely interspaced zinc finger motifs

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRB2 adhesion G protein-coupled receptor B2
AHSG alpha-2-HS-glycoprotein
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALPP alkaline phosphatase, placental
AMT aminomethyltransferase
ARMCX2 armadillo repeat containing, X-linked 2
ATG2B autophagy related 2B
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BDKRB1 bradykinin receptor B1
BTBD18 BTB (POZ) domain containing 18
C1ORF21 chromosome 1 open reading frame 21
C5ORF42 chromosome 5 open reading frame 42
CAMKMT calmodulin-lysine N-methyltransferase
CCDC71 coiled-coil domain containing 71
CFAP69 cilia and flagella associated protein 69
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
COMMD10 COMM domain containing 10
CRY2 cryptochrome circadian clock 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DDN dendrin
DEAF1 DEAF1 transcription factor
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ELSPBP1 epididymal sperm binding protein 1
FAM110B family with sequence similarity 110, member B
FAM118A family with sequence similarity 118, member A
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GAL3ST4 galactose-3-O-sulfotransferase 4
GAN gigaxonin
GJC1 gap junction protein, gamma 1, 45kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GMPR guanosine monophosphate reductase
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HDAC7 histone deacetylase 7
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2BM histone cluster 1, H2bm
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXA7 homeobox A7
HPN hepsin
IL17RB interleukin 17 receptor B
IL22 interleukin 22
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KRT4 keratin 4, type II
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LY96 lymphocyte antigen 96
MAGEA5 melanoma antigen family A5
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MN1 meningioma (disrupted in balanced translocation) 1
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
OLFML2A olfactomedin-like 2A
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PODXL2 podocalyxin-like 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR4 proline rich 4 (lacrimal)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAD51B RAD51 paralog B
RIBC2 RIB43A domain with coiled-coils 2
RNF43 ring finger protein 43
ROM1 retinal outer segment membrane protein 1
RPL10L ribosomal protein L10-like
SAMD9 sterile alpha motif domain containing 9
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC12A9 solute carrier family 12, member 9
SMO smoothened, frizzled class receptor
SNORA21 small nucleolar RNA, H/ACA box 21
SP1 Sp1 transcription factor
SPANXC SPANX family, member C
SUSD4 sushi domain containing 4
TESPA1 thymocyte expressed, positive selection associated 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM74B transmembrane protein 74B
TNS2 tensin 2
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT44 tRNA methyltransferase 44 homolog (S. cerevisiae)
TSNAXIP1 translin-associated factor X interacting protein 1
VGF VGF nerve growth factor inducible
VN1R1 vomeronasal 1 receptor 1
WDR33 WD repeat domain 33
ZNF268 zinc finger protein 268
ZNF510 zinc finger protein 510