homochlorcyclizine-7417 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the homochlorcyclizine-7417 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ALLC allantoicase
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ALX4 ALX homeobox 4
APOC4 apolipoprotein C-IV
APOM apolipoprotein M
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
C19ORF73 chromosome 19 open reading frame 73
C2ORF68 chromosome 2 open reading frame 68
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CDC14A cell division cycle 14A
CFLAR CASP8 and FADD-like apoptosis regulator
CHD5 chromodomain helicase DNA binding protein 5
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CUL9 cullin 9
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DCT dopachrome tautomerase
DDIT4 DNA-damage-inducible transcript 4
DGAT1 diacylglycerol O-acyltransferase 1
DIO2 deiodinase, iodothyronine, type II
DTNA dystrobrevin, alpha
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
E2F4 E2F transcription factor 4, p107/p130-binding
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA2 EPH receptor A2
EXPH5 exophilin 5
FADS3 fatty acid desaturase 3
FAM65A family with sequence similarity 65, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXG1 forkhead box G1
GPR87 G protein-coupled receptor 87
GSTM1 glutathione S-transferase mu 1
HFE hemochromatosis
HIST1H2BJ histone cluster 1, H2bj
HPS4 Hermansky-Pudlak syndrome 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD17 potassium channel tetramerization domain containing 17
KDM5A lysine (K)-specific demethylase 5A
KIZ kizuna centrosomal protein
KLF3 Kruppel-like factor 3 (basic)
KLHL24 kelch-like family member 24
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LPAR3 lysophosphatidic acid receptor 3
LPIN1 lipin 1
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP2 latent transforming growth factor beta binding protein 2
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MBD1 methyl-CpG binding domain protein 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MTMR3 myotubularin related protein 3
MXD3 MAX dimerization protein 3
MYO15A myosin XVA
MYO7A myosin VIIA
MYOF myoferlin
N4BP3 NEDD4 binding protein 3
NEK9 NIMA-related kinase 9
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PCDHB8 protocadherin beta 8
PCDHGB5 protocadherin gamma subfamily B, 5
PLA2G3 phospholipase A2, group III
PLAC1 placenta-specific 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTCRA pre T-cell antigen receptor alpha
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RGS12 regulator of G-protein signaling 12
RIPK4 receptor-interacting serine-threonine kinase 4
RNF19B ring finger protein 19B
RUNDC3A RUN domain containing 3A
SCAPER S-phase cyclin A-associated protein in the ER
SH3GL3 SH3-domain GRB2-like 3
SIPA1 signal-induced proliferation-associated 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNAI2 snail family zinc finger 2
SSPN sarcospan
STX2 syntaxin 2
SUGP1 SURP and G patch domain containing 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCP10L t-complex 10-like
TESK2 testis-specific kinase 2
TEX15 testis expressed 15
TMEM120B transmembrane protein 120B
TRAK1 trafficking protein, kinesin binding 1
TRIM2 tripartite motif containing 2
TRIM52 tripartite motif containing 52
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP2 ubiquitin specific peptidase 2
ZNF276 zinc finger protein 276
ZNF571 zinc finger protein 571

decreased expression

Symbol Name
ARL15 ADP-ribosylation factor-like 15
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARRB2 arrestin, beta 2
ASB7 ankyrin repeat and SOCS box containing 7
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BACE1 beta-site APP-cleaving enzyme 1
C16ORF59 chromosome 16 open reading frame 59
C19ORF40 chromosome 19 open reading frame 40
C7ORF43 chromosome 7 open reading frame 43
C9ORF78 chromosome 9 open reading frame 78
CAMKMT calmodulin-lysine N-methyltransferase
CBR3 carbonyl reductase 3
CCDC85C coiled-coil domain containing 85C
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP6 charged multivesicular body protein 6
CLUH clustered mitochondria (cluA/CLU1) homolog
COPS7B COP9 signalosome subunit 7B
CORO2A coronin, actin binding protein, 2A
CUEDC1 CUE domain containing 1
CYB5R4 cytochrome b5 reductase 4
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2
DHDDS dehydrodolichyl diphosphate synthase
ECHDC2 enoyl CoA hydratase domain containing 2
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
ELOVL4 ELOVL fatty acid elongase 4
EVPL envoplakin
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM63A family with sequence similarity 63, member A
FCHSD2 FCH and double SH3 domains 2
FIP1L1 factor interacting with PAPOLA and CPSF1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAN gigaxonin
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GJA1 gap junction protein, alpha 1, 43kDa
GPR19 G protein-coupled receptor 19
HIST1H2AG histone cluster 1, H2ag
HIST1H2AM histone cluster 1, H2am
HIST1H4J histone cluster 1, H4j
IP6K2 inositol hexakisphosphate kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
KIF18B kinesin family member 18B
KRT13 keratin 13, type I
LRRC20 leucine rich repeat containing 20
MAP9 microtubule-associated protein 9
MBTPS2 membrane-bound transcription factor peptidase, site 2
METTL2B methyltransferase like 2B
MICALL2 MICAL-like 2
MLYCD malonyl-CoA decarboxylase
MTHFSD methenyltetrahydrofolate synthetase domain containing
MUM1 melanoma associated antigen (mutated) 1
NDRG1 N-myc downstream regulated 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NES nestin
NPY5R neuropeptide Y receptor Y5
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSGEP O-sialoglycoprotein endopeptidase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKX protein kinase, X-linked
RAB4B RAB4B, member RAS oncogene family
RAP1GAP2 RAP1 GTPase activating protein 2
RASA2 RAS p21 protein activator 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RRP1 ribosomal RNA processing 1
RUFY2 RUN and FYVE domain containing 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SFT2D2 SFT2 domain containing 2
SH2D4A SH2 domain containing 4A
SHARPIN SHANK-associated RH domain interactor
SIRT2 sirtuin 2
SKA1 spindle and kinetochore associated complex subunit 1
SLC12A9 solute carrier family 12, member 9
SUN2 Sad1 and UNC84 domain containing 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBL3 transducin (beta)-like 3
TCTA T-cell leukemia translocation altered
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM110 transmembrane protein 110
TMEM115 transmembrane protein 115
TMEM209 transmembrane protein 209
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC26 tetratricopeptide repeat domain 26
TUBA3C tubulin, alpha 3c
TUBGCP5 tubulin, gamma complex associated protein 5
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WWC2 WW and C2 domain containing 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF124 zinc finger protein 124
ZNF226 zinc finger protein 226
ZNF248 zinc finger protein 248
ZNF365 zinc finger protein 365
ZNF574 zinc finger protein 574
ZNF675 zinc finger protein 675
ZSCAN9 zinc finger and SCAN domain containing 9