homochlorcyclizine-7295 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the homochlorcyclizine-7295 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARMC9 armadillo repeat containing 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF6B activating transcription factor 6 beta
BIRC3 baculoviral IAP repeat containing 3
C1ORF116 chromosome 1 open reading frame 116
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CLCN5 chloride channel, voltage-sensitive 5
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DENND3 DENN/MADD domain containing 3
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EGFR epidermal growth factor receptor
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPPK1 epiplakin 1
FAM69A family with sequence similarity 69, member A
FAS Fas cell surface death receptor
FGF5 fibroblast growth factor 5
FNDC3A fibronectin type III domain containing 3A
FOXO1 forkhead box O1
FST follistatin
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALK2 galactokinase 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GK glycerol kinase
GPR107 G protein-coupled receptor 107
GPR176 G protein-coupled receptor 176
GPRC5B G protein-coupled receptor, class C, group 5, member B
HDAC9 histone deacetylase 9
HDLBP high density lipoprotein binding protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
ICAM1 intercellular adhesion molecule 1
IL24 interleukin 24
IL6 interleukin 6
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
KDM6A lysine (K)-specific demethylase 6A
KIAA0391 KIAA0391
KLHL24 kelch-like family member 24
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPK14 mitogen-activated protein kinase 14
MET MET proto-oncogene, receptor tyrosine kinase
MFAP3 microfibrillar-associated protein 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NID2 nidogen 2 (osteonidogen)
NINJ1 ninjurin 1
NMT2 N-myristoyltransferase 2
NR3C2 nuclear receptor subfamily 3, group C, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDIA4 protein disulfide isomerase family A, member 4
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLCH1 phospholipase C, eta 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTPRF protein tyrosine phosphatase, receptor type, F
QKI QKI, KH domain containing, RNA binding
RAB3B RAB3B, member RAS oncogene family
RBMS2 RNA binding motif, single stranded interacting protein 2
RGS4 regulator of G-protein signaling 4
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SDF2L1 stromal cell-derived factor 2-like 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKIL SKI-like proto-oncogene
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS2 suppressor of cytokine signaling 2
SQSTM1 sequestosome 1
TGFB2 transforming growth factor, beta 2
TMCC1 transmembrane and coiled-coil domain family 1
TMEM50B transmembrane protein 50B
TMEM63A transmembrane protein 63A
TMF1 TATA element modulatory factor 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TTC28 tetratricopeptide repeat domain 28
TTLL7 tubulin tyrosine ligase-like family member 7
WDR25 WD repeat domain 25
ZHX2 zinc fingers and homeoboxes 2
ZNF571 zinc finger protein 571
ZSCAN2 zinc finger and SCAN domain containing 2

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALPK1 alpha-kinase 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP7B ATPase, Cu++ transporting, beta polypeptide
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEX1 brain expressed, X-linked 1
BTBD2 BTB (POZ) domain containing 2
BTBD7 BTB (POZ) domain containing 7
C1QTNF1 C1q and tumor necrosis factor related protein 1
C5 complement component 5
C6ORF47 chromosome 6 open reading frame 47
CBX8 chromobox homolog 8
CCDC88C coiled-coil domain containing 88C
CCP110 centriolar coiled coil protein 110kDa
CDON cell adhesion associated, oncogene regulated
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COQ6 coenzyme Q6 monooxygenase
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DHRS11 dehydrogenase/reductase (SDR family) member 11
DLK1 delta-like 1 homolog (Drosophila)
DNAL4 dynein, axonemal, light chain 4
EPN3 epsin 3
FAM102A family with sequence similarity 102, member A
FAM131B family with sequence similarity 131, member B
FAM222B family with sequence similarity 222, member B
FANCE Fanconi anemia, complementation group E
FHOD1 formin homology 2 domain containing 1
FHOD3 formin homology 2 domain containing 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FPGS folylpolyglutamate synthase
GPATCH2L G patch domain containing 2-like
GYS1 glycogen synthase 1 (muscle)
HAS2 hyaluronan synthase 2
HCLS1 hematopoietic cell-specific Lyn substrate 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IGFLR1 IGF-like family receptor 1
IMPACT impact RWD domain protein
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KRT4 keratin 4, type II
LIMS2 LIM and senescent cell antigen-like domains 2
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MVP major vault protein
MXD3 MAX dimerization protein 3
MXRA8 matrix-remodelling associated 8
MYL5 myosin, light chain 5, regulatory
NABP2 nucleic acid binding protein 2
NECAB3 N-terminal EF-hand calcium binding protein 3
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NLRX1 NLR family member X1
NMB neuromedin B
NME3 NME/NM23 nucleoside diphosphate kinase 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
ONECUT2 one cut homeobox 2
PALMD palmdelphin
PAQR4 progestin and adipoQ receptor family member IV
PCBP4 poly(rC) binding protein 4
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PEG3 paternally expressed 3
PEX26 peroxisomal biogenesis factor 26
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRR14L proline rich 14-like
PSKH1 protein serine kinase H1
PTCD2 pentatricopeptide repeat domain 2
RAB20 RAB20, member RAS oncogene family
RAB23 RAB23, member RAS oncogene family
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPAP2 RNA polymerase II associated protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
SCAI suppressor of cancer cell invasion
SETBP1 SET binding protein 1
SH3GLB2 SH3-domain GRB2-like endophilin B2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMA4 glucuronidase, beta pseudogene
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
STAR steroidogenic acute regulatory protein
SUN2 Sad1 and UNC84 domain containing 2
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TNS2 tensin 2
TTC31 tetratricopeptide repeat domain 31
UBTD1 ubiquitin domain containing 1
URM1 ubiquitin related modifier 1
XYLT2 xylosyltransferase II
ZNF358 zinc finger protein 358
ZNF580 zinc finger protein 580
ZNF701 zinc finger protein 701