homochlorcyclizine-2386 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the homochlorcyclizine-2386 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANXA2P3 annexin A2 pseudogene 3
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBS4 Bardet-Biedl syndrome 4
BIK BCL2-interacting killer (apoptosis-inducing)
BLZF1 basic leucine zipper nuclear factor 1
BTN3A2 butyrophilin, subfamily 3, member A2
C19ORF66 chromosome 19 open reading frame 66
CCDC186 coiled-coil domain containing 186
CCNG2 cyclin G2
CD300A CD300a molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD47 CD47 molecule
CDKL3 cyclin-dependent kinase-like 3
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CYHR1 cysteine/histidine-rich 1
CYLD cylindromatosis (turban tumor syndrome)
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DCAF15 DDB1 and CUL4 associated factor 15
DFNA5 deafness, autosomal dominant 5
DNMBP dynamin binding protein
DRD2 dopamine receptor D2
EFCAB2 EF-hand calcium binding domain 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM127B family with sequence similarity 127, member B
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAB1 GRB2-associated binding protein 1
GPR161 G protein-coupled receptor 161
GPR35 G protein-coupled receptor 35
HABP4 hyaluronan binding protein 4
HAP1 huntingtin-associated protein 1
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H2BH histone cluster 1, H2bh
HOXA1 homeobox A1
ICA1 islet cell autoantigen 1, 69kDa
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDM7A lysine (K)-specific demethylase 7A
KHK ketohexokinase (fructokinase)
KRAS Kirsten rat sarcoma viral oncogene homolog
KRIT1 KRIT1, ankyrin repeat containing
KRT75 keratin 75, type II
LRRC8B leucine rich repeat containing 8 family, member B
LY96 lymphocyte antigen 96
MAGEH1 melanoma antigen family H1
MCOLN1 mucolipin 1
MRPS14 mitochondrial ribosomal protein S14
NF1 neurofibromin 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPC1 Niemann-Pick disease, type C1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG10 paternally expressed 10
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLSCR1 phospholipid scramblase 1
PODNL1 podocan-like 1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PSME4 proteasome (prosome, macropain) activator subunit 4
PTN pleiotrophin
PYGB phosphorylase, glycogen; brain
RECQL5 RecQ protein-like 5
RGS1 regulator of G-protein signaling 1
RGS3 regulator of G-protein signaling 3
RIMS3 regulating synaptic membrane exocytosis 3
RTN2 reticulon 2
RUNX1 runt-related transcription factor 1
SERINC5 serine incorporator 5
SH3BP1 SH3-domain binding protein 1
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOGA1 suppressor of glucose, autophagy associated 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SS18 synovial sarcoma translocation, chromosome 18
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TCTA T-cell leukemia translocation altered
TGFB1 transforming growth factor, beta 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM5 tripartite motif containing 5
UBOX5 U-box domain containing 5
UGCG UDP-glucose ceramide glucosyltransferase
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF10 zinc finger protein 10
ZNF177 zinc finger protein 177
ZNF500 zinc finger protein 500
ZNF518A zinc finger protein 518A

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADGRE1 adhesion G protein-coupled receptor E1
AEN apoptosis enhancing nuclease
ALS2CL ALS2 C-terminal like
ANKRD40 ankyrin repeat domain 40
ANXA2P2 annexin A2 pseudogene 2
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOBR apolipoprotein B receptor
ARMC4 armadillo repeat containing 4
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BPHL biphenyl hydrolase-like (serine hydrolase)
C1QTNF3 C1q and tumor necrosis factor related protein 3
CASZ1 castor zinc finger 1
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CCDC9 coiled-coil domain containing 9
CD34 CD34 molecule
CD70 CD70 molecule
CDA cytidine deaminase
CDH10 cadherin 10, type 2 (T2-cadherin)
CNPY4 canopy FGF signaling regulator 4
CORT cortistatin
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DOC2A double C2-like domains, alpha
EDAR ectodysplasin A receptor
EDC4 enhancer of mRNA decapping 4
ETV4 ets variant 4
GGTLC1 gamma-glutamyltransferase light chain 1
GPR27 G protein-coupled receptor 27
GRAMD1B GRAM domain containing 1B
GRIP2 glutamate receptor interacting protein 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BE histone cluster 1, H2be
HIST1H4D histone cluster 1, H4d
HOXC8 homeobox C8
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INCENP inner centromere protein antigens 135/155kDa
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUP junction plakoglobin
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLK15 kallikrein-related peptidase 15
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAMB2 laminin, beta 2 (laminin S)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LTBP2 latent transforming growth factor beta binding protein 2
MAGEF1 melanoma antigen family F1
MAPK13 mitogen-activated protein kinase 13
MARC1 mitochondrial amidoxime reducing component 1
MDM4 MDM4, p53 regulator
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MTA2 metastasis associated 1 family, member 2
MX2 MX dynamin-like GTPase 2
NCS1 neuronal calcium sensor 1
NKX3-2 NK3 homeobox 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI1 peptidyl arginine deiminase, type I
PCDH12 protocadherin 12
PDE12 phosphodiesterase 12
PDZD7 PDZ domain containing 7
PEAK1 pseudopodium-enriched atypical kinase 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLA2G15 phospholipase A2, group XV
PRKG2 protein kinase, cGMP-dependent, type II
RAB23 RAB23, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RPAP2 RNA polymerase II associated protein 2
RPUSD2 RNA pseudouridylate synthase domain containing 2
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC15 sialic acid binding Ig-like lectin 15
SIGLEC5 sialic acid binding Ig-like lectin 5
SLC12A9 solute carrier family 12, member 9
SLC22A14 solute carrier family 22, member 14
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SOX12 SRY (sex determining region Y)-box 12
SREK1IP1 SREK1-interacting protein 1
SSTR5 somatostatin receptor 5
STXBP5L syntaxin binding protein 5-like
SYN3 synapsin III
TBC1D2 TBC1 domain family, member 2
TBXAS1 thromboxane A synthase 1 (platelet)
TMC7 transmembrane channel-like 7
TONSL tonsoku-like, DNA repair protein
TRAF2 TNF receptor-associated factor 2
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSPYL2 TSPY-like 2
UCN urocortin
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
YY2 YY2 transcription factor
ZNF276 zinc finger protein 276
ZNF510 zinc finger protein 510