hexestrol-6077 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the hexestrol-6077 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADM adrenomedullin
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALK anaplastic lymphoma receptor tyrosine kinase
ATF3 activating transcription factor 3
AVPR1B arginine vasopressin receptor 1B
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
CALCR calcitonin receptor
CAMKV CaM kinase-like vesicle-associated
CCNK cyclin K
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDRT1 CMT1A duplicated region transcript 1
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CNTD2 cyclin N-terminal domain containing 2
COL10A1 collagen, type X, alpha 1
CPN1 carboxypeptidase N, polypeptide 1
CRH corticotropin releasing hormone
CRISP2 cysteine-rich secretory protein 2
CSF1 colony stimulating factor 1 (macrophage)
CTNS cystinosin, lysosomal cystine transporter
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRD2 dopamine receptor D2
EFNB3 ephrin-B3
EGR1 early growth response 1
EML3 echinoderm microtubule associated protein like 3
FAM182B family with sequence similarity 182, member B
FAM46C family with sequence similarity 46, member C
FCGBP Fc fragment of IgG binding protein
FLRT2 fibronectin leucine rich transmembrane protein 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FRMD1 FERM domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GLB1L galactosidase, beta 1-like
GZMK granzyme K (granzyme 3; tryptase II)
HPX hemopexin
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP3 insulin-like growth factor binding protein 3
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INE1 inactivation escape 1 (non-protein coding)
INHBE inhibin, beta E
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JUN jun proto-oncogene
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KIFC3 kinesin family member C3
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLK7 kallikrein-related peptidase 7
KRT75 keratin 75, type II
LIF leukemia inhibitory factor
LUZP4 leucine zipper protein 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK11 mitogen-activated protein kinase 11
MUC3B mucin 3B, cell surface associated
MXD1 MAX dimerization protein 1
NOV nephroblastoma overexpressed
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NUP214 nucleoporin 214kDa
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
OTOR otoraplin
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARVA parvin, alpha
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDB1 pleckstrin homology-like domain, family B, member 1
POU3F4 POU class 3 homeobox 4
PRODH2 proline dehydrogenase (oxidase) 2
PROX1 prospero homeobox 1
PSG3 pregnancy specific beta-1-glycoprotein 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAI2 retinoic acid induced 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RUNX1 runt-related transcription factor 1
S100A9 S100 calcium binding protein A9
SAFB scaffold attachment factor B
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRT4 sirtuin 4
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNTA1 syntrophin, alpha 1
STAC SH3 and cysteine rich domain
TBXA2R thromboxane A2 receptor
TEX40 testis expressed 40
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM204 transmembrane protein 204
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TTC38 tetratricopeptide repeat domain 38
ULBP1 UL16 binding protein 1
VIL1 villin 1

decreased expression

Symbol Name
ALS2CL ALS2 C-terminal like
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ASB9 ankyrin repeat and SOCS box containing 9
BAHCC1 BAH domain and coiled-coil containing 1
BCAR3 breast cancer anti-estrogen resistance 3
BEX4 brain expressed, X-linked 4
BMP4 bone morphogenetic protein 4
C14ORF93 chromosome 14 open reading frame 93
C9ORF40 chromosome 9 open reading frame 40
CA5BP1 carbonic anhydrase VB pseudogene 1
CAPN5 calpain 5
CASD1 CAS1 domain containing 1
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CGREF1 cell growth regulator with EF-hand domain 1
CHKB choline kinase beta
CLCN5 chloride channel, voltage-sensitive 5
COPZ2 coatomer protein complex, subunit zeta 2
CORO7 coronin 7
CRY2 cryptochrome circadian clock 2
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP9 dual specificity phosphatase 9
EGFL7 EGF-like-domain, multiple 7
EHBP1L1 EH domain binding protein 1-like 1
FAM198B family with sequence similarity 198, member B
FOXJ2 forkhead box J2
GADD45G growth arrest and DNA-damage-inducible, gamma
GHR growth hormone receptor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR27 G protein-coupled receptor 27
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GSTCD glutathione S-transferase, C-terminal domain containing
HAMP hepcidin antimicrobial peptide
HOXA4 homeobox A4
IFI35 interferon-induced protein 35
INO80D INO80 complex subunit D
IRF2 interferon regulatory factor 2
KDM8 lysine (K)-specific demethylase 8
KIAA0125 KIAA0125
LAMB2 laminin, beta 2 (laminin S)
LMO2 LIM domain only 2 (rhombotin-like 1)
LY6D lymphocyte antigen 6 complex, locus D
MDM4 MDM4, p53 regulator
MSI1 musashi RNA-binding protein 1
MTCL1 microtubule crosslinking factor 1
MXRA7 matrix-remodelling associated 7
NABP2 nucleic acid binding protein 2
NOL10 nucleolar protein 10
OGFRL1 opioid growth factor receptor-like 1
PAIP2B poly(A) binding protein interacting protein 2B
PCDHGB5 protocadherin gamma subfamily B, 5
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
PP14571 uncharacterized LOC100130449
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTK6 protein tyrosine kinase 6
PVRL3 poliovirus receptor-related 3
RAB23 RAB23, member RAS oncogene family
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN2 Ras and Rab interactor 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SETD1A SET domain containing 1A
SETD6 SET domain containing 6
SIDT1 SID1 transmembrane family, member 1
SIX1 SIX homeobox 1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SNX16 sorting nexin 16
SP1 Sp1 transcription factor
SREBF1 sterol regulatory element binding transcription factor 1
STAG3L1 stromal antigen 3-like 1 (pseudogene)
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TARP TCR gamma alternate reading frame protein
TBC1D17 TBC1 domain family, member 17
TCHH trichohyalin
TDRD1 tudor domain containing 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMC7 transmembrane channel-like 7
TMEM165 transmembrane protein 165
TMEM180 transmembrane protein 180
TMEM53 transmembrane protein 53
TRAPPC11 trafficking protein particle complex 11
TRIM21 tripartite motif containing 21
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VAX2 ventral anterior homeobox 2
WBP2 WW domain binding protein 2
WFDC2 WAP four-disulfide core domain 2
WLS wntless Wnt ligand secretion mediator
XK X-linked Kx blood group
ZBED1 zinc finger, BED-type containing 1
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF134 zinc finger protein 134
ZNF219 zinc finger protein 219