hexestrol-2515 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the hexestrol-2515 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACAN aggrecan
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADCK4 aarF domain containing kinase 4
AFF2 AF4/FMR2 family, member 2
AGER advanced glycosylation end product-specific receptor
ARHGAP44 Rho GTPase activating protein 44
BPI bactericidal/permeability-increasing protein
C22ORF24 chromosome 22 open reading frame 24
CCDC81 coiled-coil domain containing 81
CD8B CD8b molecule
CDC25C cell division cycle 25C
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEND1 cell cycle exit and neuronal differentiation 1
CEP250 centrosomal protein 250kDa
CFAP69 cilia and flagella associated protein 69
CGA glycoprotein hormones, alpha polypeptide
CLGN calmegin
CLSTN2 calsyntenin 2
CXCL3 chemokine (C-X-C motif) ligand 3
DCHS2 dachsous cadherin-related 2
DCN decorin
DGKQ diacylglycerol kinase, theta 110kDa
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DIAPH2-AS1 DIAPH2 antisense RNA 1
DNAAF1 dynein, axonemal, assembly factor 1
ELL2 elongation factor, RNA polymerase II, 2
EML2 echinoderm microtubule associated protein like 2
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FABP3 fatty acid binding protein 3, muscle and heart
FBN1 fibrillin 1
FDPS farnesyl diphosphate synthase
FPR1 formyl peptide receptor 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GPC1 glypican 1
GRIA3 glutamate receptor, ionotropic, AMPA 3
HFE hemochromatosis
HIST1H2AL histone cluster 1, H2al
HLA-DRA major histocompatibility complex, class II, DR alpha
HRH4 histamine receptor H4
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL36G interleukin 36, gamma
KALRN kalirin, RhoGEF kinase
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIAA0513 KIAA0513
KIF3A kinesin family member 3A
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMK1 LIM domain kinase 1
LIMS2 LIM and senescent cell antigen-like domains 2
LPAR1 lysophosphatidic acid receptor 1
LPP LIM domain containing preferred translocation partner in lipoma
MANSC1 MANSC domain containing 1
MBD2 methyl-CpG binding domain protein 2
MIA2 melanoma inhibitory activity 2
MT4 metallothionein 4
MTRF1L mitochondrial translational release factor 1-like
NCS1 neuronal calcium sensor 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NIPAL2 NIPA-like domain containing 2
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRG1 neuregulin 1
PAX2 paired box 2
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM4 PDZ and LIM domain 4
PECR peroxisomal trans-2-enoyl-CoA reductase
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARA peroxisome proliferator-activated receptor alpha
PRB1 proline-rich protein BstNI subfamily 1
PRX periaxin
PTCRA pre T-cell antigen receptor alpha
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RBP4 retinol binding protein 4, plasma
RERE arginine-glutamic acid dipeptide (RE) repeats
RHOD ras homolog family member D
RXRB retinoid X receptor, beta
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNX29P2 sorting nexin 29 pseudogene 2
ST7L suppression of tumorigenicity 7 like
TBL1Y transducin (beta)-like 1, Y-linked
TFF2 trefoil factor 2
TM4SF1 transmembrane 4 L six family member 1
TMEM51 transmembrane protein 51
TNC tenascin C
TNK1 tyrosine kinase, non-receptor, 1
TNK2 tyrosine kinase, non-receptor, 2
TNNI1 troponin I type 1 (skeletal, slow)
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USP22 ubiquitin specific peptidase 22
VAV2 vav 2 guanine nucleotide exchange factor
VPREB1 pre-B lymphocyte 1
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
ZNF552 zinc finger protein 552

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACO1 aconitase 1, soluble
ADAM23 ADAM metallopeptidase domain 23
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANP32A-IT1 ANP32A intronic transcript 1
ARSB arylsulfatase B
ASPN asporin
ATAD5 ATPase family, AAA domain containing 5
BAG4 BCL2-associated athanogene 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBX7 chromobox homolog 7
CCL20 chemokine (C-C motif) ligand 20
CCRL2 chemokine (C-C motif) receptor-like 2
CD69 CD69 molecule
CHPF chondroitin polymerizing factor
CPNE1 copine I
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTNNBIP1 catenin, beta interacting protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DEPTOR DEP domain containing MTOR-interacting protein
DKK2 dickkopf WNT signaling pathway inhibitor 2
DUSP8 dual specificity phosphatase 8
ENAH enabled homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
FAM120C family with sequence similarity 120C
FAM188A family with sequence similarity 188, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGF23 fibroblast growth factor 23
FPGS folylpolyglutamate synthase
GAA glucosidase, alpha; acid
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPR18 G protein-coupled receptor 18
GSTCD glutathione S-transferase, C-terminal domain containing
HAMP hepcidin antimicrobial peptide
HAUS6 HAUS augmin-like complex, subunit 6
HINFP histone H4 transcription factor
HIST1H2BI histone cluster 1, H2bi
HP haptoglobin
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
IMPAD1 inositol monophosphatase domain containing 1
JUP junction plakoglobin
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0754 KIAA0754
LAMP5 lysosomal-associated membrane protein family, member 5
LINC00115 long intergenic non-protein coding RNA 115
LPAR4 lysophosphatidic acid receptor 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MTSS1L metastasis suppressor 1-like
MYO5C myosin VC
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NHEJ1 nonhomologous end-joining factor 1
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS1 plastin 1
POLM polymerase (DNA directed), mu
PROL1 proline rich, lacrimal 1
RAB13 RAB13, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIN1 Ras and Rab interactor 1
RIN2 Ras and Rab interactor 2
RNF122 ring finger protein 122
RNF144A ring finger protein 144A
RNF25 ring finger protein 25
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLITRK5 SLIT and NTRK-like family, member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STAT5A signal transducer and activator of transcription 5A
SYNJ2BP synaptojanin 2 binding protein
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAS2R10 taste receptor, type 2, member 10
TET3 tet methylcytosine dioxygenase 3
TEX264 testis expressed 264
TMEM212 transmembrane protein 212
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TMOD3 tropomodulin 3 (ubiquitous)
TXLNG taxilin gamma
UPB1 ureidopropionase, beta
XAB2 XPA binding protein 2
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZMAT5 zinc finger, matrin-type 5
ZNF354A zinc finger protein 354A
ZNF480 zinc finger protein 480
ZNF747 zinc finger protein 747