hesperetin-6750 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the hesperetin-6750 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ADAM11 ADAM metallopeptidase domain 11
ADAM22 ADAM metallopeptidase domain 22
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALOX5 arachidonate 5-lipoxygenase
APOE apolipoprotein E
AURKA aurora kinase A
BAAT bile acid CoA:amino acid N-acyltransferase
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BTG2 BTG family, member 2
C21ORF2 chromosome 21 open reading frame 2
CACYBP calcyclin binding protein
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CDC42 cell division cycle 42
CEL carboxyl ester lipase
CFP complement factor properdin
CHN2 chimerin 2
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CIZ1 CDKN1A interacting zinc finger protein 1
CPN2 carboxypeptidase N, polypeptide 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DCTN1 dynactin 1
DDO D-aspartate oxidase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAI2 dynein, axonemal, intermediate chain 2
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EDN3 endothelin 3
EDNRB endothelin receptor type B
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EREG epiregulin
ESR1 estrogen receptor 1
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM131B family with sequence similarity 131, member B
FEZF2 FEZ family zinc finger 2
FGFR1 fibroblast growth factor receptor 1
FOXP3 forkhead box P3
FRK fyn-related Src family tyrosine kinase
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GPR1 G protein-coupled receptor 1
GPR85 G protein-coupled receptor 85
GPR88 G protein-coupled receptor 88
GRIK1 glutamate receptor, ionotropic, kainate 1
GRSF1 G-rich RNA sequence binding factor 1
GUK1 guanylate kinase 1
IL19 interleukin 19
IL21R interleukin 21 receptor
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLHL22 kelch-like family member 22
KRT32 keratin 32, type I
LAMP1 lysosomal-associated membrane protein 1
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LRP3 low density lipoprotein receptor-related protein 3
LY75 lymphocyte antigen 75
LYZ lysozyme
MPPE1 metallophosphoesterase 1
MRPL41 mitochondrial ribosomal protein L41
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NOL10 nucleolar protein 10
NR0B1 nuclear receptor subfamily 0, group B, member 1
NT5M 5',3'-nucleotidase, mitochondrial
OMD osteomodulin
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PART1 prostate androgen-regulated transcript 1 (non-protein coding)
PARVA parvin, alpha
PCDHGB6 protocadherin gamma subfamily B, 6
PDCD2 programmed cell death 2
PDE4DIP phosphodiesterase 4D interacting protein
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PRB1 proline-rich protein BstNI subfamily 1
PRKCB protein kinase C, beta
PRO2964 uncharacterized protein PRO2964
RHO rhodopsin
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RPL14 ribosomal protein L14
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RS1 retinoschisin 1
RUNX1 runt-related transcription factor 1
S100A13 S100 calcium binding protein A13
SARM1 sterile alpha and TIR motif containing 1
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SELPLG selectin P ligand
SEPP1 selenoprotein P, plasma, 1
SIGLEC9 sialic acid binding Ig-like lectin 9
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMAD4 SMAD family member 4
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
ZNF408 zinc finger protein 408
ZNF783 zinc finger family member 783
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P1 annexin A2 pseudogene 1
ATAD5 ATPase family, AAA domain containing 5
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX4 chromobox homolog 4
CDK6 cyclin-dependent kinase 6
CENPO centromere protein O
CHM choroideremia (Rab escort protein 1)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
DDA1 DET1 and DDB1 associated 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERAP2 endoplasmic reticulum aminopeptidase 2
ERCC4 excision repair cross-complementation group 4
EXOC5 exocyst complex component 5
FBXL7 F-box and leucine-rich repeat protein 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP5 FK506 binding protein 5
FNTB farnesyltransferase, CAAX box, beta
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GALK1 galactokinase 1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GDAP1 ganglioside induced differentiation associated protein 1
GMPR guanosine monophosphate reductase
GNL1 guanine nucleotide binding protein-like 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2I general transcription factor IIi
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HDAC9 histone deacetylase 9
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HELZ helicase with zinc finger
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1E histone cluster 1, H1e
HIST1H3C histone cluster 1, H3c
HMGB3P1 high mobility group box 3 pseudogene 1
HOOK1 hook microtubule-tethering protein 1
HP1BP3 heterochromatin protein 1, binding protein 3
IFI6 interferon, alpha-inducible protein 6
IPO8 importin 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0319L KIAA0319-like
KLF3 Kruppel-like factor 3 (basic)
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT31 keratin 31, type I
LIME1 Lck interacting transmembrane adaptor 1
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYPLA2P1 lysophospholipase II pseudogene 1
MAGEH1 melanoma antigen family H1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MTA2 metastasis associated 1 family, member 2
MXD3 MAX dimerization protein 3
NAG18 NAG18 mRNA
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NMD3 NMD3 ribosome export adaptor
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARM1 prostate androgen-regulated mucin-like protein 1
PCYOX1 prenylcysteine oxidase 1
PDE12 phosphodiesterase 12
PFDN6 prefoldin subunit 6
PHC1 polyhomeotic homolog 1 (Drosophila)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
POMT2 protein-O-mannosyltransferase 2
PRF1 perforin 1 (pore forming protein)
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGS17 regulator of G-protein signaling 17
RHOBTB2 Rho-related BTB domain containing 2
SAMD9 sterile alpha motif domain containing 9
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCIN scinderin
SCYL2 SCY1-like 2 (S. cerevisiae)
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SMAD5 SMAD family member 5
STK16 serine/threonine kinase 16
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TEP1 telomerase-associated protein 1
TTPAL tocopherol (alpha) transfer protein-like
TWISTNB TWIST neighbor
TXLNG taxilin gamma
ULBP2 UL16 binding protein 2
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR4 WD repeat domain 4
ZFHX3 zinc finger homeobox 3
ZNF227 zinc finger protein 227
ZNF324 zinc finger protein 324
ZNF480 zinc finger protein 480
ZNF675 zinc finger protein 675