hereditary Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

441 genes co-occuring with the biological term hereditary in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AARS alanyl-tRNA synthetase
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ACE angiotensin I converting enzyme
ACO1 aconitase 1, soluble
ACVRL1 activin A receptor type II-like 1
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADRA2B adrenoceptor alpha 2B
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALAS1 5'-aminolevulinate synthase 1
ALDOB aldolase B, fructose-bisphosphate
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANK1 ankyrin 1, erythrocytic
AP5B1 adaptor-related protein complex 5, beta 1 subunit
APC adenomatous polyposis coli
APCDD1 adenomatosis polyposis coli down-regulated 1
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATL1 atlastin GTPase 1
ATM ATM serine/threonine kinase
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
ATXN1 ataxin 1
ATXN2 ataxin 2
AURKA aurora kinase A
B2M beta-2-microglobulin
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF12 chromosome 19 open reading frame 12
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C9ORF72 chromosome 9 open reading frame 72
CA9 carbonic anhydrase IX
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFH complement factor H
CHED1 corneal endothelial dystrophy 1 (autosomal dominant)
CHEK2 checkpoint kinase 2
CHGA chromogranin A
CKB creatine kinase, brain
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A5 collagen, type IV, alpha 5
COMT catechol-O-methyltransferase
CPB2 carboxypeptidase B2 (plasma)
CPOX coproporphyrinogen oxidase
CRP C-reactive protein, pentraxin-related
CRTC2 CREB regulated transcription coactivator 2
CRYAA crystallin, alpha A
CRYBB1 crystallin, beta B1
CRYBB2 crystallin, beta B2
CRYGD crystallin, gamma D
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST3 cystatin C
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTRC chymotrypsin C (caldecrin)
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
CYB5R3 cytochrome b5 reductase 3
CYBB cytochrome b-245, beta polypeptide
CYGB cytoglobin
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCN decorin
DDHD2 DDHD domain containing 2
DEAF1 DEAF1 transcription factor
DFNA18 deafness, autosomal dominant 18
DFNA5 deafness, autosomal dominant 5
DLG1 discs, large homolog 1 (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DRD2 dopamine receptor D2
DSC3 desmocollin 3
DSPP dentin sialophosphoprotein
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
E2F4 E2F transcription factor 4, p107/p130-binding
EDNRB endothelin receptor type B
ELAC2 elaC ribonuclease Z 2
ELANE elastase, neutrophil expressed
ENG endoglin
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
EPB42 erythrocyte membrane protein band 4.2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8L3 EPS8-like 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC4 excision repair cross-complementation group 4
ERLIN2 ER lipid raft associated 2
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXO1 exonuclease 1
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
EXTL3 exostosin-like glycosyltransferase 3
EYA4 EYA transcriptional coactivator and phosphatase 4
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FA2H fatty acid 2-hydroxylase
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM111B family with sequence similarity 111, member B
FAM134B family with sequence similarity 134, member B
FANCB Fanconi anemia, complementation group B
FANCD2 Fanconi anemia, complementation group D2
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FGA fibrinogen alpha chain
FGF23 fibroblast growth factor 23
FGFR3 fibroblast growth factor receptor 3
FH fumarate hydratase
FHIT fragile histidine triad
FHL2 four and a half LIM domains 2
FIG4 FIG4 phosphoinositide 5-phosphatase
FLT4 fms-related tyrosine kinase 4
FMR1 fragile X mental retardation 1
FOXC2 forkhead box C2
FSCN2 fascin actin-bundling protein 2, retinal
FTL ferritin, light polypeptide
FXN frataxin
FZD6 frizzled class receptor 6
G6PD glucose-6-phosphate dehydrogenase
GARS glycyl-tRNA synthetase
GATA4 GATA binding protein 4
GBA glucosidase, beta, acid
GBA2 glucosidase, beta (bile acid) 2
GDF15 growth differentiation factor 15
GDF2 growth differentiation factor 2
GFAP glial fibrillary acidic protein
GJA3 gap junction protein, alpha 3, 46kDa
GJA5 gap junction protein, alpha 5, 40kDa
GJA8 gap junction protein, alpha 8, 50kDa
GJB1 gap junction protein, beta 1, 32kDa
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GJB6 gap junction protein, beta 6, 30kDa
GLRA1 glycine receptor, alpha 1
GLRB glycine receptor, beta
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAS GNAS complex locus
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPC1 glypican 1
GPI glucose-6-phosphate isomerase
GRB10 growth factor receptor-bound protein 10
GRM1 glutamate receptor, metabotropic 1
GRN granulin
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GYPA glycophorin A (MNS blood group)
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HAMP hepcidin antimicrobial peptide
HAX1 HCLS1 associated protein X-1
HBB hemoglobin, beta
HBG1 hemoglobin, gamma A
HBG2 hemoglobin, gamma G
HFE hemochromatosis
HFE2 hemochromatosis type 2 (juvenile)
HINT1 histidine triad nucleotide binding protein 1
HLA-A major histocompatibility complex, class I, A
HOXA10 homeobox A10
HOXB13 homeobox B13
HR hair growth associated
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HTRA1 HtrA serine peptidase 1
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IL1B interleukin 1, beta
IL6 interleukin 6
INF2 inverted formin, FH2 and WH2 domain containing
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
IYD iodotyrosine deiodinase
JAK2 Janus kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4
KIAA0196 KIAA0196
KIF1A kinesin family member 1A
KIF1C kinesin family member 1C
KIF5A kinesin family member 5A
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF1 Kruppel-like factor 1 (erythroid)
KLF6 Kruppel-like factor 6
KLK1 kallikrein 1
KLKB1 kallikrein B, plasma (Fletcher factor) 1
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT86 keratin 86, type II
L1CAM L1 cell adhesion molecule
LCT lactase
LIPH lipase, member H
LITAF lipopolysaccharide-induced TNF factor
LONP1 lon peptidase 1, mitochondrial
LOX lysyl oxidase
LPAR6 lysophosphatidic acid receptor 6
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LRRK2 leucine-rich repeat kinase 2
LYZ lysozyme
MAPT microtubule-associated protein tau
MASP2 mannan-binding lectin serine peptidase 2
MAX MYC associated factor X
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR184 microRNA 184
MIR210 microRNA 210
MLH1 mutL homolog 1
MLH3 mutL homolog 3
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MPO myeloperoxidase
MPZ myelin protein zero
MPZL3 myelin protein zero-like 3
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MSR1 macrophage scavenger receptor 1
MT-ATP6 ATP synthase F0 subunit 6
MT-ND4 NADH dehydrogenase, subunit 4 (complex I)
MT-ND5 NADH dehydrogenase, subunit 5 (complex I)
MT-ND6 NADH dehydrogenase, subunit 6 (complex I)
MT-TT tRNA
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
MUTYH mutY homolog
MVK mevalonate kinase
MYH11 myosin, heavy chain 11, smooth muscle
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYO7A myosin VIIA
MYOZ2 myozenin 2
NBN nibrin
NCAM1 neural cell adhesion molecule 1
NCF1 neutrophil cytosolic factor 1
ND1
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NEFH neurofilament, heavy polypeptide
NFE2 nuclear factor, erythroid 2
NGF nerve growth factor (beta polypeptide)
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1
NKX2-1 NK2 homeobox 1
NKX3-1 NK3 homeobox 1
NLRP3 NLR family, pyrin domain containing 3
NOP56 NOP56 ribonucleoprotein
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPB natriuretic peptide B
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NT5C3A 5'-nucleotidase, cytosolic IIIA
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPA1 optic atrophy 1 (autosomal dominant)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OTSC4 otosclerosis 4
PALB2 partner and localizer of BRCA2
PALLD palladin, cytoskeletal associated protein
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PAX6 paired box 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PHEX phosphate regulating endopeptidase homolog, X-linked
PHOX2B paired-like homeobox 2b
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCD1 phospholipase C, delta 1
PLG plasminogen
PLP1 proteolipid protein 1
PMP22 peripheral myelin protein 22
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNPLA3 patatin-like phospholipase domain containing 3
PNPT1 polyribonucleotide nucleotidyltransferase 1
PON1 paraoxonase 1
POU6F2 POU class 6 homeobox 2
PRDX2 peroxiredoxin 2
PRF1 perforin 1 (pore forming protein)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROM1 prominin 1
PROS1 protein S (alpha)
PRSS1 protease, serine, 1 (trypsin 1)
PRSS2 protease, serine, 2 (trypsin 2)
PSEN2 presenilin 2
PTEN phosphatase and tensin homolog
RAD50 RAD50 homolog (S. cerevisiae)
RAD51C RAD51 paralog C
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
REEP1 receptor accessory protein 1
REEP2 receptor accessory protein 2
RET ret proto-oncogene
RHAG Rh-associated glycoprotein
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNR1 RNA, ribosomal cluster 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPGR retinitis pigmentosa GTPase regulator
RPL21 ribosomal protein L21
RPS20 ribosomal protein S20
RTKN rhotekin
RTN2 reticulon 2
RUNX1 runt-related transcription factor 1
SAFB scaffold attachment factor B
SAFB2 scaffold attachment factor B2
SAMD9 sterile alpha motif domain containing 9
SARM1 sterile alpha and TIR motif containing 1
SAX1 spastic ataxia 1 (autosomal dominant)
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHAF2 succinate dehydrogenase complex assembly factor 2
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SELE selectin E
SEPT11 septin 11
SEPT4 septin 4
SEPT9 septin 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC4A11 solute carrier family 4, sodium borate transporter, member 11
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLIT2 slit homolog 2 (Drosophila)
SMAD4 SMAD family member 4
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNURF SNRPN upstream reading frame
SOS1 son of sevenless homolog 1 (Drosophila)
SPAST spastin
SPG11 spastic paraplegia 11 (autosomal recessive)
SPG19 spastic paraplegia 19 (autosomal dominant)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPHK1 sphingosine kinase 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOP speckle-type POZ protein
SPTA1 spectrin, alpha, erythrocytic 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTB spectrin, beta, erythrocytic
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SST somatostatin
TARBP2 TAR (HIV-1) RNA binding protein 2
TDP1 tyrosyl-DNA phosphodiesterase 1
TECTA tectorin alpha
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFG TRK-fused gene
TFR2 transferrin receptor 2
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THPO thrombopoietin
TIMP2 TIMP metallopeptidase inhibitor 2
TLR4 toll-like receptor 4
TMPRSS3 transmembrane protease, serine 3
TMPRSS6 transmembrane protease, serine 6
TNF tumor necrosis factor
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNXB tenascin XB
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TPST2 tyrosylprotein sulfotransferase 2
TREX1 three prime repair exonuclease 1
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSHR thyroid stimulating hormone receptor
TTC7A tetratricopeptide repeat domain 7A
TTN titin
TTPA tocopherol (alpha) transfer protein
TTR transthyretin
TUBB4A tubulin, beta 4A class IVa
TWIST1 twist family bHLH transcription factor 1
TWIST2 twist family bHLH transcription factor 2
TYMS thymidylate synthetase
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UMPS uridine monophosphate synthetase
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VLDLR very low density lipoprotein receptor
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae)
WIF1 WNT inhibitory factor 1
WNK1 WNK lysine deficient protein kinase 1
XDH xanthine dehydrogenase
ZFYVE26 zinc finger, FYVE domain containing 26
ZFYVE27 zinc finger, FYVE domain containing 27