hepatoma cell Gene Set

Dataset TISSUES Curated Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Primary carcinoma of the liver cells. It ranges from a well-differentiated tumour difficult to distinguish from normal hepatocytes to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic or may form giant cells. Several classification schemes have been suggested. Hepatocellular carcinoma is very rare in the united states and western europe, but it is one of the most common cancers in eastern asia and sub-saharan africa. The cases are preponderantly male and, racially, whites have the lowest rates. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000608)
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Genes

261 proteins highly expressed in the tissue hepatoma cell from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD6 abhydrolase domain containing 6
ABI1 abl-interactor 1
ABLIM3 actin binding LIM protein family, member 3
ACACA acetyl-CoA carboxylase alpha
ACBD4 acyl-CoA binding domain containing 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTBL2 actin, beta-like 2
ADHFE1 alcohol dehydrogenase, iron containing, 1
ADI1 acireductone dioxygenase 1
ALKBH5 AlkB family member 5, RNA demethylase
AMDHD1 amidohydrolase domain containing 1
ANAPC5 anaphase promoting complex subunit 5
AP5M1 adaptor-related protein complex 5, mu 1 subunit
APOF apolipoprotein F
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARMC10 armadillo repeat containing 10
ASNSD1 asparagine synthetase domain containing 1
ATF5 activating transcription factor 5
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP13A1 ATPase type 13A1
ATP9A ATPase, class II, type 9A
AZI2 5-azacytidine induced 2
BFAR bifunctional apoptosis regulator
BRAF B-Raf proto-oncogene, serine/threonine kinase
C9ORF78 chromosome 9 open reading frame 78
CACYBP calcyclin binding protein
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CADPS2 Ca++-dependent secretion activator 2
CALML5 calmodulin-like 5
CASZ1 castor zinc finger 1
CAV2 caveolin 2
CCAR1 cell division cycle and apoptosis regulator 1
CCDC40 coiled-coil domain containing 40
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CEP290 centrosomal protein 290kDa
CEP85 centrosomal protein 85kDa
CHD7 chromodomain helicase DNA binding protein 7
CHP2 calcineurin-like EF-hand protein 2
CLTC clathrin, heavy chain (Hc)
CORO7 coronin 7
CPN2 carboxypeptidase N, polypeptide 2
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
CRTC3 CREB regulated transcription coactivator 3
CTAG2 cancer/testis antigen 2
CWC22 CWC22 spliceosome-associated protein
CYFIP1 cytoplasmic FMR1 interacting protein 1
DCAF11 DDB1 and CUL4 associated factor 11
DCAF12 DDB1 and CUL4 associated factor 12
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DGAT2 diacylglycerol O-acyltransferase 2
DGCR8 DGCR8 microprocessor complex subunit
DGKD diacylglycerol kinase, delta 130kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNM1L dynamin 1-like
DPP8 dipeptidyl-peptidase 8
DTD1 D-tyrosyl-tRNA deacylase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECI2 enoyl-CoA delta isomerase 2
EHD4 EH-domain containing 4
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF3A eukaryotic translation initiation factor 3, subunit A
EIF3M eukaryotic translation initiation factor 3, subunit M
ELMOD3 ELMO/CED-12 domain containing 3
ENGASE endo-beta-N-acetylglucosaminidase
EPAS1 endothelial PAS domain protein 1
ERMP1 endoplasmic reticulum metallopeptidase 1
ESRP2 epithelial splicing regulatory protein 2
ESYT1 extended synaptotagmin-like protein 1
ETNK2 ethanolamine kinase 2
FAM60A family with sequence similarity 60, member A
FBXO11 F-box protein 11
FBXO45 F-box protein 45
FERMT1 fermitin family member 1
FGF2 fibroblast growth factor 2 (basic)
FNBP1L formin binding protein 1-like
FOCAD focadhesin
G2E3 G2/M-phase specific E3 ubiquitin protein ligase
GABPB1 GA binding protein transcription factor, beta subunit 1
GBA glucosidase, beta, acid
GCC1 GRIP and coiled-coil domain containing 1
GCKR glucokinase (hexokinase 4) regulator
GGT1 gamma-glutamyltransferase 1
GPR35 G protein-coupled receptor 35
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GZF1 GDNF-inducible zinc finger protein 1
HAVCR2 hepatitis A virus cellular receptor 2
HAX1 HCLS1 associated protein X-1
HBP1 HMG-box transcription factor 1
HCFC1 host cell factor C1
HDAC10 histone deacetylase 10
HDDC2 HD domain containing 2
HDGF hepatoma-derived growth factor
HEATR6 HEAT repeat containing 6
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H2BO histone cluster 1, H2bo
HLF hepatic leukemia factor
HMGA2 high mobility group AT-hook 2
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13
IFI27L2 interferon, alpha-inducible protein 27-like 2
IFT46 intraflagellar transport 46
IGHMBP2 immunoglobulin mu binding protein 2
INO80D INO80 complex subunit D
INTS3 integrator complex subunit 3
ISYNA1 inositol-3-phosphate synthase 1
KARS lysyl-tRNA synthetase
KLF11 Kruppel-like factor 11
KLHDC2 kelch domain containing 2
KLHL21 kelch-like family member 21
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRBOX4 KRAB box domain containing 4
KYNU kynureninase
LGALS1 lectin, galactoside-binding, soluble, 1
LGTN ligatin
LIMA1 LIM domain and actin binding 1
LIMK2 LIM domain kinase 2
LMBR1 limb development membrane protein 1
LMF1 lipase maturation factor 1
LONRF1 LON peptidase N-terminal domain and ring finger 1
LRRC47 leucine rich repeat containing 47
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L1P1 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene 1
MAGEC2 melanoma antigen family C2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MB21D2 Mab-21 domain containing 2
MED15 mediator complex subunit 15
MET MET proto-oncogene, receptor tyrosine kinase
MFSD2A major facilitator superfamily domain containing 2A
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MKL1 megakaryoblastic leukemia (translocation) 1
MKS1 Meckel syndrome, type 1
MRPL50 mitochondrial ribosomal protein L50
MSL3 male-specific lethal 3 homolog (Drosophila)
MTDH metadherin
MTMR10 myotubularin related protein 10
MVK mevalonate kinase
MYO5C myosin VC
NIN ninein (GSK3B interacting protein)
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL9 nucleolar protein 9
NPAS1 neuronal PAS domain protein 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRF1 nuclear respiratory factor 1
NSUN5 NOP2/Sun domain family, member 5
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NUGGC nuclear GTPase, germinal center associated
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PARD3 par-3 family cell polarity regulator
PCIF1 PDX1 C-terminal inhibiting factor 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PHF20 PHD finger protein 20
PON3 paraoxonase 3
PPAT phosphoribosyl pyrophosphate amidotransferase
PPP1R18 protein phosphatase 1, regulatory subunit 18
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PQLC2 PQ loop repeat containing 2
PRMT5 protein arginine methyltransferase 5
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTBP1 polypyrimidine tract binding protein 1
PXYLP1 2-phosphoxylose phosphatase 1
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1
QARS glutaminyl-tRNA synthetase
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RBBP6 retinoblastoma binding protein 6
RBM15 RNA binding motif protein 15
RC3H2 ring finger and CCCH-type domains 2
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RFC1 replication factor C (activator 1) 1, 145kDa
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1
RIOK2 RIO kinase 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF43 ring finger protein 43
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPL28 ribosomal protein L28
RPL7 ribosomal protein L7
RPS12 ribosomal protein S12
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase
RYR3 ryanodine receptor 3
SART3 squamous cell carcinoma antigen recognized by T cells 3
SCAP SREBF chaperone
SEC11A SEC11 homolog A (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SESN2 sestrin 2
SIRT5 sirtuin 5
SLA2 Src-like-adaptor 2
SLC22A9 solute carrier family 22 (organic anion transporter), member 9
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
SLC38A2 solute carrier family 38, member 2
SLC38A4 solute carrier family 38, member 4
SLC38A5 solute carrier family 38, member 5
SMIM7 small integral membrane protein 7
SMOX spermine oxidase
SORBS2 sorbin and SH3 domain containing 2
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRSF11 serine/arginine-rich splicing factor 11
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SYBU syntabulin (syntaxin-interacting)
TASP1 taspase, threonine aspartase, 1
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TBRG4 transforming growth factor beta regulator 4
TESK1 testis-specific kinase 1
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TFDP3 transcription factor Dp family, member 3
TMEM139 transmembrane protein 139
TMEM176A transmembrane protein 176A
TP73 tumor protein p73
TPR translocated promoter region, nuclear basket protein
TPTE transmembrane phosphatase with tensin homology
TPX2 TPX2, microtubule-associated
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TUFT1 tuftelin 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
URI1 URI1, prefoldin-like chaperone
USP47 ubiquitin specific peptidase 47
USP48 ubiquitin specific peptidase 48
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VARS valyl-tRNA synthetase
VIM vimentin
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WBP1L WW domain binding protein 1-like
WDR77 WD repeat domain 77
WDR82 WD repeat domain 82
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZBTB14 zinc finger and BTB domain containing 14
ZC4H2 zinc finger, C4H2 domain containing
ZDHHC7 zinc finger, DHHC-type containing 7
ZFHX3 zinc finger homeobox 3
ZFR zinc finger RNA binding protein
ZNF211 zinc finger protein 211
ZNF322 zinc finger protein 322
ZNF396 zinc finger protein 396
ZNF397 zinc finger protein 397
ZNF407 zinc finger protein 407
ZNF513 zinc finger protein 513
ZNF574 zinc finger protein 574
ZNF621 zinc finger protein 621
ZNHIT6 zinc finger, HIT-type containing 6
ZW10 zw10 kinetochore protein