heparan sulfate proteoglycan biosynthetic process Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues. (Gene Ontology, GO_0015012)
External Link http://amigo.geneontology.org/amigo/term/GO:0015012
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Genes

16 genes participating in the heparan sulfate proteoglycan biosynthetic process biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
B3GAT3 beta-1,3-glucuronyltransferase 3
DSE dermatan sulfate epimerase
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
EXTL1 exostosin-like glycosyltransferase 1
EXTL2 exostosin-like glycosyltransferase 2
EXTL3 exostosin-like glycosyltransferase 3
GLCE glucuronic acid epimerase
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
XYLT1 xylosyltransferase I
XYLT2 xylosyltransferase II