hemochromatosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A metal metabolism disorder characterized by the accumulation of iron in various organs of the body. (Human Disease Ontology, DOID_2352)
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Genes

129 genes co-occuring with the disease hemochromatosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HFE hemochromatosis 4.34857
TF transferrin 2.94002
HAMP hepcidin antimicrobial peptide 2.85382
TFR2 transferrin receptor 2 2.77941
HFE2 hemochromatosis type 2 (juvenile) 2.68322
FTL ferritin, light polypeptide 2.6432
FTH1 ferritin, heavy polypeptide 1 2.63235
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 2.25531
TFRC transferrin receptor 2.11097
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.82549
CYBRD1 cytochrome b reductase 1 1.55468
HEPH hephaestin 1.55468
TMPRSS6 transmembrane protease, serine 6 1.53084
UROD uroporphyrinogen decarboxylase 1.52732
CASR calcium-sensing receptor 1.52468
HCG4P11 HLA complex group 4 pseudogene 11 1.52424
HLA-F major histocompatibility complex, class I, F 1.52424
HLA-A major histocompatibility complex, class I, A 1.45133
UBE2D1 ubiquitin-conjugating enzyme E2D 1 1.30925
BMP6 bone morphogenetic protein 6 1.29134
CP ceruloplasmin (ferroxidase) 1.18927
HLA-B major histocompatibility complex, class I, B 1.18367
B2M beta-2-microglobulin 1.03704
HMGN4 high mobility group nucleosomal binding domain 4 0.883521
HLA-C major histocompatibility complex, class I, C 0.801564
SEC23B Sec23 homolog B (S. cerevisiae) 0.758601
ACO1 aconitase 1, soluble 0.741923
PKLR pyruvate kinase, liver and RBC 0.734622
AFP alpha-fetoprotein 0.707559
ZKSCAN8 zinc finger with KRAB and SCAN domains 8 0.705547
RGMB repulsive guidance molecule family member b 0.693499
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.685091
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.67312
NEO1 neogenin 1 0.672324
ZSCAN9 zinc finger and SCAN domain containing 9 0.668742
RGMA repulsive guidance molecule family member a 0.668742
WDR75 WD repeat domain 75 0.663975
ANKAR ankyrin and armadillo repeat containing 0.663975
ASNSD1 asparagine synthetase domain containing 1 0.663975
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 0.663975
MFSD6 major facilitator superfamily domain containing 6 0.663975
TMEM194B transmembrane protein 194B 0.663975
C2ORF88 chromosome 2 open reading frame 88 0.663975
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.662387
INS insulin 0.647348
HIST1H1T histone cluster 1, H1t 0.625319
C14ORF177 chromosome 14 open reading frame 177 0.6003
GGT1 gamma-glutamyltransferase 1 0.594454
CD80 CD80 molecule 0.591727
DIRC1 disrupted in renal carcinoma 1 0.591337
PKM pyruvate kinase, muscle 0.58939
F5 coagulation factor V (proaccelerin, labile factor) 0.583941
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.582773
MED9 mediator complex subunit 9 0.571884
HPX hemopexin 0.56722
HLA-E major histocompatibility complex, class I, E 0.546644
ALAS2 5'-aminolevulinate synthase 2 0.543542
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.530381
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.52536
F2 coagulation factor II (thrombin) 0.516879
TEX14 testis expressed 14 0.51611
ALAD aminolevulinate dehydratase 0.51188
USF2 upstream transcription factor 2, c-fos interacting 0.503441
HP haptoglobin 0.496175
HPR haptoglobin-related protein 0.490072
HMOX2 heme oxygenase 2 0.484364
PARD6G par-6 family cell polarity regulator gamma 0.482084
UBE2J1 ubiquitin-conjugating enzyme E2, J1 0.468819
PANK1 pantothenate kinase 1 0.457487
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 0.454093
SFXN1 sideroflexin 1 0.452962
BMP2 bone morphogenetic protein 2 0.445805
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.443923
GDF15 growth differentiation factor 15 0.434148
SMAD9 SMAD family member 9 0.43227
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.425514
DGUOK deoxyguanosine kinase 0.416147
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.408666
FXN frataxin 0.401572
CDAN1 codanin 1 0.398962
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 0.395608
INPP1 inositol polyphosphate-1-phosphatase 0.393746
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.393374
GGT2 gamma-glutamyltransferase 2 0.393001
ANKH ANKH inorganic pyrophosphate transport regulator 0.392629
BMPR1A bone morphogenetic protein receptor, type IA 0.388538
ALB albumin 0.380739
SMAD5 SMAD family member 5 0.376661
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.340906
TTC37 tetratricopeptide repeat domain 37 0.339806
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.32373
IREB2 iron-responsive element binding protein 2 0.32009
SCARA5 scavenger receptor class A, member 5 0.294772
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.293334
ALPPL2 alkaline phosphatase, placental-like 2 0.287952
ALPP alkaline phosphatase, placental 0.287593
ALPL alkaline phosphatase, liver/bone/kidney 0.287235
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.286519
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.279367
HMGN2 high mobility group nucleosomal binding domain 2 0.279011
SLC46A1 solute carrier family 46 (folate transporter), member 1 0.279011
GCG glucagon 0.25207
F13A1 coagulation factor XIII, A1 polypeptide 0.248203
UROS uroporphyrinogen III synthase 0.247501
CRP C-reactive protein, pentraxin-related 0.238054
ZNF202 zinc finger protein 202 0.232836
IL6 interleukin 6 0.232489
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 0.225229
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.223509
CCL8 chemokine (C-C motif) ligand 8 0.222136
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.218715
CAPNS1 calpain, small subunit 1 0.218374
PGBD1 piggyBac transposable element derived 1 0.215992
HMOX1 heme oxygenase 1 0.212608
APOE apolipoprotein E 0.210589
PNPLA3 patatin-like phospholipase domain containing 3 0.205585
ZNF165 zinc finger protein 165 0.203604
TNF tumor necrosis factor 0.202946
CREB3L3 cAMP responsive element binding protein 3-like 3 0.20229
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.194548
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.189244
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.180937
PPOX protoporphyrinogen oxidase 0.178403
PCSK7 proprotein convertase subtilisin/kexin type 7 0.174881
GRB7 growth factor receptor-bound protein 7 0.171785
TCTA T-cell leukemia translocation altered 0.170299
UNC13D unc-13 homolog D (C. elegans) 0.169571
STEAP3 STEAP family member 3, metalloreductase 0.159658
CALR calreticulin 0.158605