heliotrine-4277 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the heliotrine-4277 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ADRA1A adrenoceptor alpha 1A
ANGPTL2 angiopoietin-like 2
ARHGAP35 Rho GTPase activating protein 35
BMP5 bone morphogenetic protein 5
BMPR1B bone morphogenetic protein receptor, type IB
C19ORF73 chromosome 19 open reading frame 73
CASZ1 castor zinc finger 1
CD248 CD248 molecule, endosialin
CD80 CD80 molecule
CD86 CD86 molecule
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CLCN7 chloride channel, voltage-sensitive 7
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTNND2 catenin (cadherin-associated protein), delta 2
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYTH3 cytohesin 3
DCSTAMP dendrocyte expressed seven transmembrane protein
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE1 deoxyribonuclease I
EFCAB6 EF-hand calcium binding domain 6
ELAC2 elaC ribonuclease Z 2
ELN elastin
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAP fibroblast activation protein, alpha
GALR3 galanin receptor 3
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GRK5 G protein-coupled receptor kinase 5
HIST1H2BO histone cluster 1, H2bo
HOXD1 homeobox D1
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFT140 intraflagellar transport 140
IL2 interleukin 2
IRF4 interferon regulatory factor 4
IRX4 iroquois homeobox 4
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KDM5B lysine (K)-specific demethylase 5B
KHK ketohexokinase (fructokinase)
KLHL35 kelch-like family member 35
KLK13 kallikrein-related peptidase 13
KLK7 kallikrein-related peptidase 7
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT85 keratin 85, type II
LAD1 ladinin 1
LCAT lecithin-cholesterol acyltransferase
LRP2BP LRP2 binding protein
LTC4S leukotriene C4 synthase
MAP2 microtubule-associated protein 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAST2 microtubule associated serine/threonine kinase 2
MEGF6 multiple EGF-like-domains 6
MSX2 msh homeobox 2
NF1 neurofibromin 1
OCA2 oculocutaneous albinism II
OR1F1 olfactory receptor, family 1, subfamily F, member 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PBX1 pre-B-cell leukemia homeobox 1
PCDH12 protocadherin 12
PCDHGA3 protocadherin gamma subfamily A, 3
PEX16 peroxisomal biogenesis factor 16
PKP3 plakophilin 3
PLSCR2 phospholipid scramblase 2
PNPLA2 patatin-like phospholipase domain containing 2
POU2F3 POU class 2 homeobox 3
PQLC2 PQ loop repeat containing 2
PRB1 proline-rich protein BstNI subfamily 1
PRKCQ protein kinase C, theta
RAB40C RAB40C, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS12 regulator of G-protein signaling 12
RIMS3 regulating synaptic membrane exocytosis 3
RRAGD Ras-related GTP binding D
SAG S-antigen; retina and pineal gland (arrestin)
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNX1 sorting nexin 1
SPEF1 sperm flagellar 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUGP1 SURP and G patch domain containing 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRIM3 tripartite motif containing 3
TTLL1 tubulin tyrosine ligase-like family member 1
UBE3A ubiquitin protein ligase E3A
VPREB1 pre-B lymphocyte 1
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
VTN vitronectin
ZPBP zona pellucida binding protein

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD8 abhydrolase domain containing 8
ADTRP androgen-dependent TFPI-regulating protein
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKH ANKH inorganic pyrophosphate transport regulator
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP12 Rho GTPase activating protein 12
ARMCX2 armadillo repeat containing, X-linked 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ASTN2 astrotactin 2
AXIN1 axin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCORL1 BCL6 corepressor-like 1
BOLA1 bolA family member 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C17ORF53 chromosome 17 open reading frame 53
C17ORF75 chromosome 17 open reading frame 75
C4ORF29 chromosome 4 open reading frame 29
CA9 carbonic anhydrase IX
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CD82 CD82 molecule
CES3 carboxylesterase 3
COL21A1 collagen, type XXI, alpha 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DEAF1 DEAF1 transcription factor
DENND4A DENN/MADD domain containing 4A
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
FAM204A family with sequence similarity 204, member A
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNS galactosamine (N-acetyl)-6-sulfatase
GK3P glycerol kinase 3 pseudogene
HDAC5 histone deacetylase 5
HIST1H2BJ histone cluster 1, H2bj
HLA-DMA major histocompatibility complex, class II, DM alpha
HOMER2 homer scaffolding protein 2
HPS4 Hermansky-Pudlak syndrome 4
IFNA17 interferon, alpha 17
IL11RA interleukin 11 receptor, alpha
IL7 interleukin 7
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIAA0319L KIAA0319-like
KLHL36 kelch-like family member 36
LMNB2 lamin B2
LRP2 low density lipoprotein receptor-related protein 2
LRRK1 leucine-rich repeat kinase 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTG1 mitochondrial ribosome-associated GTPase 1
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NFS1 NFS1 cysteine desulfurase
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
OLFML3 olfactomedin-like 3
PALM paralemmin
PARPBP PARP1 binding protein
PCSK7 proprotein convertase subtilisin/kexin type 7
PDZD2 PDZ domain containing 2
PDZK1 PDZ domain containing 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
QTRT1 queuine tRNA-ribosyltransferase 1
RABL6 RAB, member RAS oncogene family-like 6
RPAP2 RNA polymerase II associated protein 2
RPP25 ribonuclease P/MRP 25kDa subunit
RUNX1-IT1 RUNX1 intronic transcript 1
SCG5 secretogranin V
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPIDR scaffolding protein involved in DNA repair
TCTN1 tectonic family member 1
TEP1 telomerase-associated protein 1
TEX30 testis expressed 30
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMUB2 transmembrane and ubiquitin-like domain containing 2
TTC33 tetratricopeptide repeat domain 33
TWISTNB TWIST neighbor
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UNC119 unc-119 homolog (C. elegans)
UNC13B unc-13 homolog B (C. elegans)
USP18 ubiquitin specific peptidase 18
VCPKMT valosin containing protein lysine (K) methyltransferase
XYLT2 xylosyltransferase II
ZNF10 zinc finger protein 10
ZNF112 zinc finger protein 112
ZNF215 zinc finger protein 215
ZNF230 zinc finger protein 230
ZNF286A zinc finger protein 286A
ZNF33B zinc finger protein 33B