heliotrine-2180 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the heliotrine-2180 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ALDOB aldolase B, fructose-bisphosphate
APOC4 apolipoprotein C-IV
BIN1 bridging integrator 1
BTNL3 butyrophilin-like 3
C1ORF95 chromosome 1 open reading frame 95
C21ORF2 chromosome 21 open reading frame 2
CD6 CD6 molecule
CDK10 cyclin-dependent kinase 10
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CFB complement factor B
CNTNAP1 contactin associated protein 1
CPEB3 cytoplasmic polyadenylation element binding protein 3
CRYGC crystallin, gamma C
DBP D site of albumin promoter (albumin D-box) binding protein
DCAKD dephospho-CoA kinase domain containing
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
ERICH1 glutamate-rich 1
FGF17 fibroblast growth factor 17
GAREM GRB2 associated, regulator of MAPK1
GLRB glycine receptor, beta
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPM6B glycoprotein M6B
GPR137 G protein-coupled receptor 137
GRIP2 glutamate receptor interacting protein 2
GRM1 glutamate receptor, metabotropic 1
GTPBP1 GTP binding protein 1
HDAC7 histone deacetylase 7
HEG1 heart development protein with EGF-like domains 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IGLL1 immunoglobulin lambda-like polypeptide 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIF5A kinesin family member 5A
LOC730101 uncharacterized LOC730101
LPAR3 lysophosphatidic acid receptor 3
LTBP3 latent transforming growth factor beta binding protein 3
MAP7 microtubule-associated protein 7
MARC1 mitochondrial amidoxime reducing component 1
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MECOM MDS1 and EVI1 complex locus
MFAP3L microfibrillar-associated protein 3-like
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NOTCH3 notch 3
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
OPRL1 opiate receptor-like 1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PARP11 poly (ADP-ribose) polymerase family, member 11
PCDH9 protocadherin 9
PEX16 peroxisomal biogenesis factor 16
PKNOX1 PBX/knotted 1 homeobox 1
PKNOX2 PBX/knotted 1 homeobox 2
PLSCR3 phospholipid scramblase 3
PMP22 peripheral myelin protein 22
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCQ protein kinase C, theta
PRLR prolactin receptor
PRODH2 proline dehydrogenase (oxidase) 2
PRSS22 protease, serine, 22
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RUFY3 RUN and FYVE domain containing 3
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SFN stratifin
SFTPB surfactant protein B
SFTPC surfactant protein C
SIM2 single-minded family bHLH transcription factor 2
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMPX small muscle protein, X-linked
SMR3A submaxillary gland androgen regulated protein 3A
SORBS3 sorbin and SH3 domain containing 3
SOX2 SRY (sex determining region Y)-box 2
SPDEF SAM pointed domain containing ETS transcription factor
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPTB spectrin, beta, erythrocytic
STAB1 stabilin 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYTL2 synaptotagmin-like 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX40 testis expressed 40
TFF2 trefoil factor 2
TMEM140 transmembrane protein 140
TPD52L1 tumor protein D52-like 1
TTLL7 tubulin tyrosine ligase-like family member 7
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACOX2 acyl-CoA oxidase 2, branched chain
ACPP acid phosphatase, prostate
ADAM15 ADAM metallopeptidase domain 15
ADGRE3 adhesion G protein-coupled receptor E3
ADGRG2 adhesion G protein-coupled receptor G2
AMPD2 adenosine monophosphate deaminase 2
ANXA2P2 annexin A2 pseudogene 2
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ASL argininosuccinate lyase
C16ORF59 chromosome 16 open reading frame 59
CD300C CD300c molecule
CDK3 cyclin-dependent kinase 3
CHMP6 charged multivesicular body protein 6
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CNR2 cannabinoid receptor 2 (macrophage)
CORO7 coronin 7
CORT cortistatin
CTSD cathepsin D
DEAF1 DEAF1 transcription factor
DOK3 docking protein 3
DOLK dolichol kinase
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GLCE glucuronic acid epimerase
GPR27 G protein-coupled receptor 27
GSTA4 glutathione S-transferase alpha 4
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-J major histocompatibility complex, class I, J (pseudogene)
IDI2-AS1 IDI2 antisense RNA 1
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL22 interleukin 22
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INCENP inner centromere protein antigens 135/155kDa
IQCC IQ motif containing C
ISOC2 isochorismatase domain containing 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLHL28 kelch-like family member 28
KLK5 kallikrein-related peptidase 5
KRT8P12 keratin 8 pseudogene 12
LPPR3 lipid phosphate phosphatase-related protein type 3
LRRC20 leucine rich repeat containing 20
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAPK12 mitogen-activated protein kinase 12
MBTPS2 membrane-bound transcription factor peptidase, site 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MED9 mediator complex subunit 9
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MVD mevalonate (diphospho) decarboxylase
MXD3 MAX dimerization protein 3
NBEA neurobeachin
NFE2L3 nuclear factor, erythroid 2-like 3
NKX3-2 NK3 homeobox 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PARG poly (ADP-ribose) glycohydrolase
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PHC1 polyhomeotic homolog 1 (Drosophila)
PITRM1 pitrilysin metallopeptidase 1
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLTP phospholipid transfer protein
POM121L2 POM121 transmembrane nucleoporin-like 2
PTPRS protein tyrosine phosphatase, receptor type, S
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3A RAB3A, member RAS oncogene family
RHOBTB2 Rho-related BTB domain containing 2
RNF126P1 ring finger protein 126 pseudogene 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RRP1 ribosomal RNA processing 1
SFT2D2 SFT2 domain containing 2
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNRPC small nuclear ribonucleoprotein polypeptide C
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAS2R10 taste receptor, type 2, member 10
TBXAS1 thromboxane A synthase 1 (platelet)
TGFBR1 transforming growth factor, beta receptor 1
TICAM1 toll-like receptor adaptor molecule 1
TRAF1 TNF receptor-associated factor 1
TRIM45 tripartite motif containing 45
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTLL1 tubulin tyrosine ligase-like family member 1
TUBA4B tubulin, alpha 4b
WASF3 WAS protein family, member 3
WNT16 wingless-type MMTV integration site family, member 16
XDH xanthine dehydrogenase
XYLT2 xylosyltransferase II
ZNF155 zinc finger protein 155
ZNF34 zinc finger protein 34
ZNF573 zinc finger protein 573
ZNF74 zinc finger protein 74