hecogenin-7175 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the hecogenin-7175 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM17 ADAM metallopeptidase domain 17
AKR1C2 aldo-keto reductase family 1, member C2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
AVL9 AVL9 homolog (S. cerevisiase)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CC2D1A coiled-coil and C2 domain containing 1A
CCNO cyclin O
CD302 CD302 molecule
CD4 CD4 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLDN1 claudin 1
CLIP4 CAP-GLY domain containing linker protein family, member 4
CLUAP1 clusterin associated protein 1
CTAG2 cancer/testis antigen 2
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
DBT dihydrolipoamide branched chain transacylase E2
DCAF4 DDB1 and CUL4 associated factor 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DPF1 D4, zinc and double PHD fingers family 1
DUSP10 dual specificity phosphatase 10
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EMX1 empty spiracles homeobox 1
ESR1 estrogen receptor 1
FBRS fibrosin
FCF1 FCF1 rRNA-processing protein
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF6 fibroblast growth factor 6
FHL1 four and a half LIM domains 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GLP1R glucagon-like peptide 1 receptor
GLS glutaminase
GMEB1 glucocorticoid modulatory element binding protein 1
GOSR1 golgi SNAP receptor complex member 1
HDLBP high density lipoprotein binding protein
HFE hemochromatosis
HIST1H1E histone cluster 1, H1e
HIST1H4F histone cluster 1, H4f
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSR insulin receptor
KIAA0485 uncharacterized LOC57235
KIF13B kinesin family member 13B
LOC257152 uncharacterized LOC257152
MAOA monoamine oxidase A
MBD2 methyl-CpG binding domain protein 2
MIIP migration and invasion inhibitory protein
MKL1 megakaryoblastic leukemia (translocation) 1
MVK mevalonate kinase
MYO1B myosin IB
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
OVOL2 ovo-like zinc finger 2
PACS1 phosphofurin acidic cluster sorting protein 1
PAPPA2 pappalysin 2
PARD6B par-6 family cell polarity regulator beta
PGAP3 post-GPI attachment to proteins 3
PKNOX1 PBX/knotted 1 homeobox 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
PRKD3 protein kinase D3
PRLR prolactin receptor
PXDC1 PX domain containing 1
RARG retinoic acid receptor, gamma
RCAN1 regulator of calcineurin 1
RIN2 Ras and Rab interactor 2
RNF39 ring finger protein 39
RPL7 ribosomal protein L7
RPLP2 ribosomal protein, large, P2
RPS4Y1 ribosomal protein S4, Y-linked 1
SAMD9 sterile alpha motif domain containing 9
SETD1B SET domain containing 1B
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SSX3 synovial sarcoma, X breakpoint 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STK4 serine/threonine kinase 4
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
THOC5 THO complex 5
THRA thyroid hormone receptor, alpha
TSPYL2 TSPY-like 2
UBA6 ubiquitin-like modifier activating enzyme 6
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZER1 zyg-11 related, cell cycle regulator
ZFHX2 zinc finger homeobox 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
ACOT8 acyl-CoA thioesterase 8
AKR1C3 aldo-keto reductase family 1, member C3
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASAP1-IT1 ASAP1 intronic transcript 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
C14ORF132 chromosome 14 open reading frame 132
C16ORF59 chromosome 16 open reading frame 59
CGREF1 cell growth regulator with EF-hand domain 1
CLASRP CLK4-associating serine/arginine rich protein
COL4A5 collagen, type IV, alpha 5
COQ3 coenzyme Q3 methyltransferase
CRBN cereblon
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EAF2 ELL associated factor 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELMO3 engulfment and cell motility 3
ETAA1 Ewing tumor-associated antigen 1
FANCC Fanconi anemia, complementation group C
FKBP10 FK506 binding protein 10, 65 kDa
GAN gigaxonin
GDAP2 ganglioside induced differentiation associated protein 2
GPR87 G protein-coupled receptor 87
GPRC5C G protein-coupled receptor, class C, group 5, member C
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIRA histone cell cycle regulator
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IGFBP6 insulin-like growth factor binding protein 6
INF2 inverted formin, FH2 and WH2 domain containing
IRF2BP1 interferon regulatory factor 2 binding protein 1
KAT2A K(lysine) acetyltransferase 2A
KIAA0922 KIAA0922
KLHL36 kelch-like family member 36
KRT86 keratin 86, type II
LRRC8E leucine rich repeat containing 8 family, member E
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAPK12 mitogen-activated protein kinase 12
MAPKBP1 mitogen-activated protein kinase binding protein 1
MAST3 microtubule associated serine/threonine kinase 3
MATK megakaryocyte-associated tyrosine kinase
NCAPD3 non-SMC condensin II complex, subunit D3
NDRG1 N-myc downstream regulated 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRBF2 nuclear receptor binding factor 2
NUBP2 nucleotide binding protein 2
NUPL2 nucleoporin like 2
PELI1 pellino E3 ubiquitin protein ligase 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLD2 phospholipase D2
PNPLA6 patatin-like phospholipase domain containing 6
POR P450 (cytochrome) oxidoreductase
PPT2 palmitoyl-protein thioesterase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB27B RAB27B, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBL1 retinoblastoma-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF121 ring finger protein 121
RPAP1 RNA polymerase II associated protein 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCAMP4 secretory carrier membrane protein 4
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SETD6 SET domain containing 6
SH2D4A SH2 domain containing 4A
SIRT2 sirtuin 2
SLC12A8 solute carrier family 12, member 8
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SPATA2L spermatogenesis associated 2-like
SUN2 Sad1 and UNC84 domain containing 2
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX19 T-box 19
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM115 transmembrane protein 115
TMEM184C transmembrane protein 184C
TNRC6B trinucleotide repeat containing 6B
TPST2 tyrosylprotein sulfotransferase 2
TRAF5 TNF receptor-associated factor 5
TRAIP TRAF interacting protein
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
TYK2 tyrosine kinase 2
UBXN6 UBX domain protein 6
URGCP upregulator of cell proliferation
VAV1 vav 1 guanine nucleotide exchange factor
WDR19 WD repeat domain 19
WDR4 WD repeat domain 4
WDR60 WD repeat domain 60
ZC3H12A zinc finger CCCH-type containing 12A
ZMAT5 zinc finger, matrin-type 5
ZNF248 zinc finger protein 248