heart disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cardiovascular system disease that involves the heart. (Human Disease Ontology, DOID_114)
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Genes

225 genes associated with the disease heart disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SCN10A sodium channel, voltage gated, type X alpha subunit 2.31033
SLC35F1 solute carrier family 35, member F1 1.54448
PHACTR1 phosphatase and actin regulator 1 1.45255
TBX5 T-box 5 1.33613
NFIA nuclear factor I/A 1.25426
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.2206
RNF207 ring finger protein 207 1.17894
CLCN6 chloride channel, voltage-sensitive 6 1.12703
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 1.09588
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.07383
ZFHX3 zinc finger homeobox 3 1.07383
HSF2 heat shock transcription factor 2 1.05198
SCN5A sodium channel, voltage gated, type V alpha subunit 1.02486
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1.00628
TRIB2 tribbles pseudokinase 2 0.982645
ZNF385B zinc finger protein 385B 0.978353
HAND1 heart and neural crest derivatives expressed 1 0.974661
PRRX1 paired related homeobox 1 0.971299
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.971299
TBX20 T-box 20 0.965481
LINC00477 long intergenic non-protein coding RNA 477 0.932337
SYNE2 spectrin repeat containing, nuclear envelope 2 0.910378
MAML2 mastermind-like 2 (Drosophila) 0.901326
CREBRF CREB3 regulatory factor 0.897589
CAV1 caveolin 1, caveolae protein, 22kDa 0.850113
BAG3 BCL2-associated athanogene 3 0.850113
LIG3 ligase III, DNA, ATP-dependent 0.835734
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 0.825265
MEIS1 Meis homeobox 1 0.817078
C9ORF3 chromosome 9 open reading frame 3 0.7623
ITGA9 integrin, alpha 9 0.7623
MRPS6 mitochondrial ribosomal protein S6 0.745324
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.728541
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.724323
OLFML2B olfactomedin-like 2B 0.69843
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.69843
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.682635
C1ORF185 chromosome 1 open reading frame 185 0.682635
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.682635
GOSR2 golgi SNAP receptor complex member 2 0.661797
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.661797
SETBP1 SET binding protein 1 0.65413
SLC12A9 solute carrier family 12, member 9 0.65413
ESR1 estrogen receptor 1 0.647573
KCTD1 potassium channel tetramerization domain containing 1 0.641775
C1ORF226 chromosome 1 open reading frame 226 0.63207
MIA3 melanoma inhibitory activity family, member 3 0.63207
ZBTB17 zinc finger and BTB domain containing 17 0.63207
HEATR5B HEAT repeat containing 5B 0.602429
FADS1 fatty acid desaturase 1 0.602429
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.602429
ARHGAP24 Rho GTPase activating protein 24 0.58494
SYNPO2L synaptopodin 2-like 0.572184
TKT transketolase 0.552621
CXCL12 chemokine (C-X-C motif) ligand 12 0.544585
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.537125
USP3 ubiquitin specific peptidase 3 0.52461
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.52461
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.52461
WDR12 WD repeat domain 12 0.52461
PRKCA protein kinase C, alpha 0.52461
SULF2 sulfatase 2 0.52461
KLF12 Kruppel-like factor 12 0.52461
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.486425
CASQ2 calsequestrin 2 (cardiac muscle) 0.486425
COL17A1 collagen, type XVII, alpha 1 0.486425
LAMA1 laminin, alpha 1 0.486425
UFSP1 UFM1-specific peptidase 1 (non-functional) 0.486425
WNT11 wingless-type MMTV integration site family, member 11 0.464771
NGDN neuroguidin, EIF4E binding protein 0.464771
GALC galactosylceramidase 0.464771
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.449873
ACYP2 acylphosphatase 2, muscle type 0.449873
ADGRD1 adhesion G protein-coupled receptor D1 0.449873
YTHDC2 YTH domain containing 2 0.449873
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.438544
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.429338
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3 0.4215
GJA1 gap junction protein, alpha 1, 43kDa 0.4215
CD34 CD34 molecule 0.4215
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.4215
SLIT2 slit homolog 2 (Drosophila) 0.403461
C12ORF42 chromosome 12 open reading frame 42 0.403461
FAM183A family with sequence similarity 183, member A 0.403461
DEGS2 delta(4)-desaturase, sphingolipid 2 0.403461
ESRRG estrogen-related receptor gamma 0.403461
DPT dermatopontin 0.368757
TRIM40 tripartite motif containing 40 0.368757
SNAI2 snail family zinc finger 2 0.345945
ATF1 activating transcription factor 1 0.345945
TEKT3 tektin 3 0.345945
WNT8A wingless-type MMTV integration site family, member 8A 0.345945
CXCR4 chemokine (C-X-C motif) receptor 4 0.345945
MARC1 mitochondrial amidoxime reducing component 1 0.345945
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.345945
PLCE1 phospholipase C, epsilon 1 0.327313
ARL5B ADP-ribosylation factor-like 5B 0.327313
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.327313
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 0.327313
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) 0.311576
PCDH15 protocadherin-related 15 0.311576
RCSD1 RCSD domain containing 1 0.311576
ACVR1 activin A receptor, type I 0.311576
TBC1D4 TBC1 domain family, member 4 0.297866
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 0.297866
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.297866
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 0.285417
PARP4 poly (ADP-ribose) polymerase family, member 4 0.285417
FAS Fas cell surface death receptor 0.285417
SVIP small VCP/p97-interacting protein 0.285417
ARHGAP10 Rho GTPase activating protein 10 0.285417
TMEM44 transmembrane protein 44 0.285417
RAI14 retinoic acid induced 14 0.274608
RPL3 ribosomal protein L3 0.274608
PTPRG protein tyrosine phosphatase, receptor type, G 0.274608
FGF1 fibroblast growth factor 1 (acidic) 0.274608
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.264872
CLEC14A C-type lectin domain family 14, member A 0.264872
COL4A2 collagen, type IV, alpha 2 0.264872
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.264872
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.256228
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.256228
OTUD7A OTU deubiquitinase 7A 0.256228
PARP15 poly (ADP-ribose) polymerase family, member 15 0.256228
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.256228
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.256228
GALR1 galanin receptor 1 0.256228
ZFPM2 zinc finger protein, FOG family member 2 0.256228
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.256228
CNOT1 CCR4-NOT transcription complex, subunit 1 0.256228
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.256228
FRMD4A FERM domain containing 4A 0.256228
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.197766
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.197766
TTN titin 0.197766
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 0.197766
IL5RA interleukin 5 receptor, alpha 0.197766
CLSTN2 calsyntenin 2 0.197766
FMO1 flavin containing monooxygenase 1 0.197766
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.197766
CLDN15 claudin 15 0.197766
CEP85L centrosomal protein 85kDa-like 0.197766
ELMO1 engulfment and cell motility 1 0.197766
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.197766
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.197766
COL8A1 collagen, type VIII, alpha 1 0.197766
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.197766
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.197766
TENM1 teneurin transmembrane protein 1 0.197766
TEX43 testis expressed 43 0.197766
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.197766
OCM2 oncomodulin 2 0.197766
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 0.197766
CA8 carbonic anhydrase VIII 0.197766
SPACA1 sperm acrosome associated 1 0.197766
MCTP2 multiple C2 domains, transmembrane 2 0.15771
RAP1GAP2 RAP1 GTPase activating protein 2 0.15771
HNRNPA1P4 heterogeneous nuclear ribonucleoprotein A1 pseudogene 4 0.15771
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 0.15771
OSBPL6 oxysterol binding protein-like 6 0.15771
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.15771
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.15771
RPUSD4 RNA pseudouridylate synthase domain containing 4 0.15771
SIN3A SIN3 transcription regulator family member A 0.15771
LTA lymphotoxin alpha 0.15771
LZTS1 leucine zipper, putative tumor suppressor 1 0.15771
STK32B serine/threonine kinase 32B 0.15771
CD36 CD36 molecule (thrombospondin receptor) 0.15771
ISL1 ISL LIM homeobox 1 0.15771
GPM6A glycoprotein M6A 0.126165
XYLB xylulokinase homolog (H. influenzae) 0.126165
RYR2 ryanodine receptor 2 (cardiac) 0.126165
PDZRN3 PDZ domain containing ring finger 3 0.126165
ARHGAP25 Rho GTPase activating protein 25 0.126165
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 0.126165
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.126165
PRL prolactin 0.126165
FAM189A1 family with sequence similarity 189, member A1 0.100789
MOB3B MOB kinase activator 3B 0.100789
ZC3H12C zinc finger CCCH-type containing 12C 0.100789
SFRP2 secreted frizzled-related protein 2 0.100789
DCN decorin 0.100789
CLDN14 claudin 14 0.100789
DDX59 DEAD (Asp-Glu-Ala-Asp) box polypeptide 59 0.100789
PHF11 PHD finger protein 11 0.100789
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.100789
C12ORF74 chromosome 12 open reading frame 74 0.100789
PDZD8 PDZ domain containing 8 0.080593
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.080593
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.080593
PLXNA2 plexin A2 0.080593
WRN Werner syndrome, RecQ helicase-like 0.080593
BCHE butyrylcholinesterase 0.080593
BMPR1B bone morphogenetic protein receptor, type IB 0.080593
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.080593
CFAP44 cilia and flagella associated protein 44 0.080593
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.080593
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.080593
CHL1 cell adhesion molecule L1-like 0.080593
FOXP1 forkhead box P1 0.080593
EVX1 even-skipped homeobox 1 0.064973
NUDT12 nudix (nucleoside diphosphate linked moiety X)-type motif 12 0.064973
AGA aspartylglucosaminidase 0.064973
NBPF22P neuroblastoma breakpoint family, member 22, pseudogene 0.064973
HLX H2.0-like homeobox 0.064973
C22ORF34 chromosome 22 open reading frame 34 0.064973
PARVA parvin, alpha 0.064973
PDE4B phosphodiesterase 4B, cAMP-specific 0.064973
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.064973
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.064973
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.064973
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 0.052255
PRKCE protein kinase C, epsilon 0.052255
RASL11A RAS-like, family 11, member A 0.052255
CH25H cholesterol 25-hydroxylase 0.052255
PARM1 prostate androgen-regulated mucin-like protein 1 0.052255
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) 0.052255
DCLK1 doublecortin-like kinase 1 0.052255
FGF14 fibroblast growth factor 14 0.052255
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.043246
RPS17P5 ribosomal protein S17 pseudogene 5 0.043246
NPAS3 neuronal PAS domain protein 3 0.043246
MBP myelin basic protein 0.043246
IFRD1 interferon-related developmental regulator 1 0.043246
XKR9 XK, Kell blood group complex subunit-related family, member 9 0.043246