heart conduction disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A cardiovascular system disease that involves the heart's electrical conduction system. (Human Disease Ontology, DOID_10273)
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Genes

344 genes co-occuring with the disease heart conduction disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SCN5A sodium channel, voltage gated, type V alpha subunit 3.98308
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.05315
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 2.01112
SCN3B sodium channel, voltage gated, type III beta subunit 2.00332
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.98343
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 1.95347
RANGRF RAN guanine nucleotide release factor 1.84499
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.70087
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.68362
SCN1B sodium channel, voltage gated, type I beta subunit 1.6791
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 1.64128
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.61844
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 1.56711
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.53392
SCN2B sodium channel, voltage gated, type II beta subunit 1.51281
SCN4B sodium channel, voltage gated, type IV beta subunit 1.49306
NOTCH1 notch 1 1.47154
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.461
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 1.4184
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.40789
ANK2 ankyrin 2, neuronal 1.35463
CA5B carbonic anhydrase VB, mitochondrial 1.3542
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 1.30707
RYR2 ryanodine receptor 2 (cardiac) 1.28173
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.25471
ST20 suppressor of tumorigenicity 20 1.25124
NAV1 neuron navigator 1 1.24906
TRPM4 transient receptor potential cation channel, subfamily M, member 4 1.23039
PKP2 plakophilin 2 1.21262
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.20613
SCN3A sodium channel, voltage gated, type III alpha subunit 1.20569
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 1.2031
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 1.19057
GJA5 gap junction protein, alpha 5, 40kDa 1.18453
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 1.02144
MSTO1 misato 1, mitochondrial distribution and morphology regulator 1.00879
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.00161
IRX4 iroquois homeobox 4 0.987271
TBX5 T-box 5 0.985164
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.974221
SAMD8 sterile alpha motif domain containing 8 0.946603
MYL7 myosin, light chain 7, regulatory 0.935385
PRSS30P protease, serine, 30, pseudogene 0.930414
SCGB1D2 secretoglobin, family 1D, member 2 0.918436
TBX3 T-box 3 0.872053
IGLV2-8 immunoglobulin lambda variable 2-8 0.848307
NKX2-6 NK2 homeobox 6 0.84544
FGF11 fibroblast growth factor 11 0.825768
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.812642
IRF6 interferon regulatory factor 6 0.804436
NPPA natriuretic peptide A 0.761454
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.752898
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.743954
CAV3 caveolin 3 0.741517
CHD4 chromodomain helicase DNA binding protein 4 0.731381
DPP6 dipeptidyl-peptidase 6 0.725716
HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 0.718443
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.716828
FBXO42 F-box protein 42 0.707961
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.707961
TMEM43 transmembrane protein 43 0.70233
KCNIP2 Kv channel interacting protein 2 0.695905
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.687491
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.685891
GATA5 GATA binding protein 5 0.676308
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.673917
FPGT fucose-1-phosphate guanylyltransferase 0.672324
C9ORF3 chromosome 9 open reading frame 3 0.67113
IRX5 iroquois homeobox 5 0.670333
PRKAG3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit 0.660008
SCN10A sodium channel, voltage gated, type X alpha subunit 0.653276
RGS6 regulator of G-protein signaling 6 0.640251
NAV2 neuron navigator 2 0.634349
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.63042
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.6214
PODXL podocalyxin-like 0.619442
SGSM3 small G protein signaling modulator 3 0.616312
IGLV2-14 immunoglobulin lambda variable 2-14 0.612792
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.612401
RCAN2 regulator of calcineurin 2 0.610448
TBX2 T-box 2 0.609276
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.597181
KCNT1 potassium channel, sodium activated subfamily T, member 1 0.591337
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 0.585108
SUGP1 SURP and G patch domain containing 1 0.58005
SLMAP sarcolemma associated protein 0.573828
FGF12 fibroblast growth factor 12 0.573439
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.567997
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.566443
EVC Ellis van Creveld protein 0.564889
VDAC3 voltage-dependent anion channel 3 0.564112
GJA1 gap junction protein, alpha 1, 43kDa 0.538118
GSPT1 G1 to S phase transition 1 0.53657
ANK1 ankyrin 1, erythrocytic 0.535796
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.529994
ACOT13 acyl-CoA thioesterase 13 0.524202
GJC3 gap junction protein, gamma 3, 30.2kDa 0.521888
IRX6 iroquois homeobox 6 0.505739
TNNT2 troponin T type 2 (cardiac) 0.504973
IRX1 iroquois homeobox 1 0.503058
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.501527
PRMT6 protein arginine methyltransferase 6 0.497703
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.496939
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.495793
ERAS ES cell expressed Ras 0.482464
JPH2 junctophilin 2 0.480566
FBXL15 F-box and leucine-rich repeat protein 15 0.466928
GATA6 GATA binding protein 6 0.460506
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.457487
FGF14 fibroblast growth factor 14 0.455601
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.451454
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.450701
SLN sarcolipin 0.446182
GREM2 gremlin 2, DAN family BMP antagonist 0.443923
LCK LCK proto-oncogene, Src family tyrosine kinase 0.438658
KIAA0101 KIAA0101 0.435275
NINJ1 ninjurin 1 0.424389
USO1 USO1 vesicle transport factor 0.406051
MYBPC1 myosin binding protein C, slow type 0.404184
WARS tryptophanyl-tRNA synthetase 0.390769
CASQ2 calsequestrin 2 (cardiac muscle) 0.389653
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.380739
TPTE transmembrane phosphatase with tensin homology 0.368149
HIST1H1A histone cluster 1, H1a 0.362978
GLE1 GLE1 RNA export mediator 0.360395
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.35892
GYS1 glycogen synthase 1 (muscle) 0.355972
TIMELESS timeless circadian clock 0.355235
NBPF10 neuroblastoma breakpoint family, member 10 0.353027
PITX2 paired-like homeodomain 2 0.35082
JUP junction plakoglobin 0.349349
CANX calnexin 0.335778
ACE angiotensin I converting enzyme 0.335778
TUBGCP4 tubulin, gamma complex associated protein 4 0.335046
EVC2 Ellis van Creveld syndrome 2 0.331025
PDZD2 PDZ domain containing 2 0.32774
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.316819
CARM1 coactivator-associated arginine methyltransferase 1 0.313189
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.303059
MIR133B microRNA 133b 0.286519
PLAT plasminogen activator, tissue 0.283297
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.28294
HRC histidine rich calcium binding protein 0.279367
HBE1 hemoglobin, epsilon 1 0.279367
LAMP2 lysosomal-associated membrane protein 2 0.277584
MBD1 methyl-CpG binding domain protein 1 0.272953
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.272597
AADACL3 arylacetamide deacetylase-like 3 0.272241
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.27153
ZNF85 zinc finger protein 85 0.269753
BSN bassoon presynaptic cytomatrix protein 0.268687
DLG5 discs, large homolog 5 (Drosophila) 0.253127
DLG1 discs, large homolog 1 (Drosophila) 0.246098
THBS4 thrombospondin 4 0.244345
EMD emerin 0.241895
DMD dystrophin 0.240847
CBS cystathionine-beta-synthase 0.226952
GATA4 GATA binding protein 4 0.224196
DSG2 desmoglein 2 0.217693
PGAM2 phosphoglycerate mutase 2 (muscle) 0.212271
NPR3 natriuretic peptide receptor 3 0.209918
ACADVL acyl-CoA dehydrogenase, very long chain 0.208914
DUT deoxyuridine triphosphatase 0.206913
SLK STE20-like kinase 0.204923
HVCN1 hydrogen voltage gated channel 1 0.200331
DSC2 desmocollin 2 0.200331
HES2 hes family bHLH transcription factor 2 0.195501
JAG1 jagged 1 0.185612
PEG10 paternally expressed 10 0.185612
INS insulin 0.183541
PRMT1 protein arginine methyltransferase 1 0.182957
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.177576
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.173832
RCAN1 regulator of calcineurin 1 0.170299
YARS tyrosyl-tRNA synthetase 0.170054
TRIM21 tripartite motif containing 21 0.169468
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.169091
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.168381
GAA glucosidase, alpha; acid 0.164359
CPLX4 complexin 4 0.161912
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.161523
RIPK4 receptor-interacting serine-threonine kinase 4 0.160387
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.160387
GRHL1 grainyhead-like 1 (Drosophila) 0.160021
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.159658
MAP9 microtubule-associated protein 9 0.158266
RGS4 regulator of G-protein signaling 4 0.157602
TROVE2 TROVE domain family, member 2 0.144105
SSB Sjogren syndrome antigen B (autoantigen La) 0.143252
LMNA lamin A/C 0.142955
FUS FUS RNA binding protein 0.142231
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.141233
BLVRA biliverdin reductase A 0.141175
ICK intestinal cell (MAK-like) kinase 0.140813
HLA-DOB major histocompatibility complex, class II, DO beta 0.139786
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.139689
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.139536
NLE1 notchless homolog 1 (Drosophila) 0.139379
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.138787
TNNI3 troponin I type 3 (cardiac) 0.138539
ERV3-1 endogenous retrovirus group 3, member 1 0.138058
NKX2-5 NK2 homeobox 5 0.137639
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.137191
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.136079
ARHGAP24 Rho GTPase activating protein 24 0.136033
CALR calreticulin 0.135736
PPT1 palmitoyl-protein thioesterase 1 0.13502
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.134201
STK11 serine/threonine kinase 11 0.133978
ACSL1 acyl-CoA synthetase long-chain family member 1 0.13385
IGLV3-9 immunoglobulin lambda variable 3-9 (gene/pseudogene) 0.133548
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1 0.133298
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 0.132964
C6ORF25 chromosome 6 open reading frame 25 0.132953
SDPR serum deprivation response 0.132899
DNAH8 dynein, axonemal, heavy chain 8 0.132844
RLN2 relaxin 2 0.132574
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.131892
NODAL nodal growth differentiation factor 0.131818
IGHV1-2 immunoglobulin heavy variable 1-2 0.131769
BMP2 bone morphogenetic protein 2 0.131732
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.131354
RRAD Ras-related associated with diabetes 0.131068
PYGM phosphorylase, glycogen, muscle 0.130774
DTNA dystrobrevin, alpha 0.130624
PLN phospholamban 0.130402
DHDH dihydrodiol dehydrogenase (dimeric) 0.129783
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.129694
PDLIM1 PDZ and LIM domain 1 0.12965
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.129483
BCHE butyrylcholinesterase 0.129331
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.129223
RND3 Rho family GTPase 3 0.129034
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.128956
CHM choroideremia (Rab escort protein 1) 0.128893
PER1 period circadian clock 1 0.128634
KLK15 kallikrein-related peptidase 15 0.128601
PRIMA1 proline rich membrane anchor 1 0.128388
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 0.128337
ARID1A AT rich interactive domain 1A (SWI-like) 0.12817
ADGRL4 adhesion G protein-coupled receptor L4 0.127775
TP73 tumor protein p73 0.127404
CRYAB crystallin, alpha B 0.127333
TGFB1 transforming growth factor, beta 1 0.127261
BIN2 bridging integrator 2 0.126986
FAF1 Fas (TNFRSF6) associated factor 1 0.126268
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.125834
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.125262
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 0.125114
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 0.125072
FOXO4 forkhead box O4 0.124861
FKTN fukutin 0.124537
HDAC3 histone deacetylase 3 0.124428
EFS embryonal Fyn-associated substrate 0.124319
INA internexin neuronal intermediate filament protein, alpha 0.124231
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.12405
TWIST1 twist family bHLH transcription factor 1 0.124005
CFD complement factor D (adipsin) 0.124005
CA1 carbonic anhydrase I 0.123735
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.123666
TERF2 telomeric repeat binding factor 2 0.123386
NPPB natriuretic peptide B 0.123317
COX5A cytochrome c oxidase subunit Va 0.12327
CCNA2 cyclin A2 0.122937
PSAT1 phosphoserine aminotransferase 1 0.121903
PTCH1 patched 1 0.121774
IGLV5-52 immunoglobulin lambda variable 5-52 0.121568
IGLV3-10 immunoglobulin lambda variable 3-10 0.121311
ANXA6 annexin A6 0.121125
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.121018
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 0.120859
IARS isoleucyl-tRNA synthetase 0.120832
ADRB1 adrenoceptor beta 1 0.120535
CRP C-reactive protein, pentraxin-related 0.120508
NGF nerve growth factor (beta polypeptide) 0.120425
FDX1 ferredoxin 1 0.1199
FH fumarate hydratase 0.119814
GJC1 gap junction protein, gamma 1, 45kDa 0.119303
CAPN3 calpain 3, (p94) 0.118834
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 0.118775
MNX1 motor neuron and pancreas homeobox 1 0.118717
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.117716
LY96 lymphocyte antigen 96 0.117529
CD1C CD1c molecule 0.117247
PIDD1 p53-induced death domain protein 1 0.116994
SIX2 SIX homeobox 2 0.116116
NKX6-2 NK6 homeobox 2 0.115816
APOH apolipoprotein H (beta-2-glycoprotein I) 0.11575
DES desmin 0.115104
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.114126
KL klotho 0.113914
EHF ets homologous factor 0.113661
RNF112 ring finger protein 112 0.113552
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.113515
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.11263
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.112217
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.112179
FHL2 four and a half LIM domains 2 0.111952
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.111797
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.111603
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.111487
MGAM maltase-glucoamylase 0.111371
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.111293
MB myoglobin 0.110622
CXADR coxsackie virus and adenovirus receptor 0.110144
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.110104
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.109981
APLNR apelin receptor 0.10994
CDK2 cyclin-dependent kinase 2 0.109899
HTN3 histatin 3 0.109899
DSC3 desmocollin 3 0.109858
MGP matrix Gla protein 0.109776
ZNF185 zinc finger protein 185 (LIM domain) 0.109571
ACHE acetylcholinesterase (Yt blood group) 0.10891
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.108825
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.108699
BTNL2 butyrophilin-like 2 0.108656
CD59 CD59 molecule, complement regulatory protein 0.108488
MLX MLX, MAX dimerization protein 0.108361
PYGB phosphorylase, glycogen; brain 0.108319
PYGL phosphorylase, glycogen, liver 0.107936
KLF10 Kruppel-like factor 10 0.107806
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.107633
ADORA2A adenosine A2a receptor 0.107546
TLR7 toll-like receptor 7 0.107503
MEGF6 multiple EGF-like-domains 6 0.107199
CLCN1 chloride channel, voltage-sensitive 1 0.107199
SPIC Spi-C transcription factor (Spi-1/PU.1 related) 0.106938
PRRC2A proline-rich coiled-coil 2A 0.106626
MME membrane metallo-endopeptidase 0.106537
JMJD6 jumonji domain containing 6 0.105548
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.105456
MMD monocyte to macrophage differentiation-associated 0.105045
GGT1 gamma-glutamyltransferase 1 0.104908
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.104489
MECOM MDS1 and EVI1 complex locus 0.104348
IGLV7-43 immunoglobulin lambda variable 7-43 0.104254
AMY2A amylase, alpha 2A (pancreatic) 0.103786
ETV3 ets variant 3 0.103739
PER2 period circadian clock 2 0.103549
TNC tenascin C 0.103212
SMOX spermine oxidase 0.103116
DLL1 delta-like 1 (Drosophila) 0.10302
SDCBP syndecan binding protein (syntenin) 0.102295