head and neck cancer Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx. (Human Disease Ontology, DOID_11934)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:11934
Similar Terms
Downloads & Tools

Genes

308 genes associated with the disease head and neck cancer in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
NBAS neuroblastoma amplified sequence 1.24032
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.21064
IFNLR1 interferon, lambda receptor 1 1.19504
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 1.14463
PCDH9 protocadherin 9 1.10419
LPP LIM domain containing preferred translocation partner in lipoma 1.08467
RARS arginyl-tRNA synthetase 1.06405
CALCR calcitonin receptor 1.05943
MALRD1 MAM and LDL receptor class A domain containing 1 1.04846
SLC51A solute carrier family 51, alpha subunit 1.02945
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 1.02138
ARHGAP35 Rho GTPase activating protein 35 1.00827
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.00596
DTNB dystrobrevin, beta 0.995478
ZFAND4 zinc finger, AN1-type domain 4 0.989716
CNTNAP2 contactin associated protein-like 2 0.986376
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.977726
SMAD6 SMAD family member 6 0.971169
AKAP13 A kinase (PRKA) anchor protein 13 0.964758
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.959448
KLHL32 kelch-like family member 32 0.958374
APP amyloid beta (A4) precursor protein 0.958374
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.958374
PTPRJ protein tyrosine phosphatase, receptor type, J 0.958374
TRAPPC9 trafficking protein particle complex 9 0.958374
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.929316
IL7R interleukin 7 receptor 0.926808
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.915976
HSP90AA6P heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene 0.915976
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.90019
FRMD5 FERM domain containing 5 0.892579
LOC339975 uncharacterized LOC339975 0.891373
METTL2A methyltransferase like 2A 0.887161
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.887161
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.886521
CHN2 chimerin 2 0.885252
GPR149 G protein-coupled receptor 149 0.885252
BSG basigin (Ok blood group) 0.88338
DERA deoxyribose-phosphate aldolase (putative) 0.882764
AIG1 androgen-induced 1 0.88034
C4ORF45 chromosome 4 open reading frame 45 0.88034
EGFR epidermal growth factor receptor 0.88034
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.88034
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.88034
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.88034
C20ORF196 chromosome 20 open reading frame 196 0.88034
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.88034
RYR2 ryanodine receptor 2 (cardiac) 0.88034
MAP2 microtubule-associated protein 2 0.88034
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.879151
MCTP1 multiple C2 domains, transmembrane 1 0.874542
CADM1 cell adhesion molecule 1 0.86494
PLK3 polo-like kinase 3 0.862937
RNF144B ring finger protein 144B 0.859451
DNAH6 dynein, axonemal, heavy chain 6 0.858922
CASZ1 castor zinc finger 1 0.858397
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.856837
FAM71D family with sequence similarity 71, member D 0.851812
CDK8 cyclin-dependent kinase 8 0.838141
UBASH3B ubiquitin associated and SH3 domain containing B 0.835216
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.834806
CHD9 chromodomain helicase DNA binding protein 9 0.831584
NRXN3 neurexin 3 0.831584
TPK1 thiamin pyrophosphokinase 1 0.831584
ADAMTSL3 ADAMTS-like 3 0.831584
PXDNL peroxidasin-like 0.831584
ELMO1 engulfment and cell motility 1 0.831584
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.831584
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.831584
ZNF385D zinc finger protein 385D 0.831584
ERBB4 erb-b2 receptor tyrosine kinase 4 0.831584
BMPR1B bone morphogenetic protein receptor, type IB 0.831584
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.831584
SMAD3 SMAD family member 3 0.830304
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.822728
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.819144
SUSD5 sushi domain containing 5 0.818364
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.818364
COL25A1 collagen, type XXV, alpha 1 0.817207
PRICKLE1 prickle homolog 1 (Drosophila) 0.813813
CDH13 cadherin 13 0.812707
NOL8 nucleolar protein 8 0.810175
KIAA1671 KIAA1671 0.807358
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.804959
USP45 ubiquitin specific peptidase 45 0.804621
CAPSL calcyphosine-like 0.802948
PAX2 paired box 2 0.801304
P3H2 prolyl 3-hydroxylase 2 0.799531
DSE dermatan sulfate epimerase 0.799531
FAM207A family with sequence similarity 207, member A 0.79774
CSMD1 CUB and Sushi multiple domains 1 0.79774
FAM179B family with sequence similarity 179, member B 0.797385
NRG3 neuregulin 3 0.794247
AOX2P aldehyde oxidase 2 pseudogene 0.794247
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.794247
ALPK3 alpha-kinase 3 0.794247
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.794247
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.794247
FGF12 fibroblast growth factor 12 0.794247
CCDC67 coiled-coil domain containing 67 0.794247
PTPRD protein tyrosine phosphatase, receptor type, D 0.794247
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.794247
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.794247
LPA lipoprotein, Lp(a) 0.794247
VIT vitrin 0.788239
RHD Rh blood group, D antigen 0.787593
CLCN6 chloride channel, voltage-sensitive 6 0.785047
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.784108
KCNIP1 Kv channel interacting protein 1 0.78287
SECTM1 secreted and transmembrane 1 0.778649
TMEM248 transmembrane protein 248 0.778355
ZBTB7C zinc finger and BTB domain containing 7C 0.776603
MYLK myosin light chain kinase 0.775452
ZNF652 zinc finger protein 652 0.774882
SCFD2 sec1 family domain containing 2 0.774882
CENPP centromere protein P 0.774032
ZNF407 zinc finger protein 407 0.77375
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.770158
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.766699
FMN2 formin 2 0.766112
MEMO1 mediator of cell motility 1 0.764084
DCLK1 doublecortin-like kinase 1 0.764084
LINC00540 long intergenic non-protein coding RNA 540 0.764084
SOX5 SRY (sex determining region Y)-box 5 0.764084
ARMC8 armadillo repeat containing 8 0.764084
FRMD4A FERM domain containing 4A 0.764084
AGBL1 ATP/GTP binding protein-like 1 0.763511
SPAG16 sperm associated antigen 16 0.76125
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.76125
ADGRA3 adhesion G protein-coupled receptor A3 0.760414
CLSTN2 calsyntenin 2 0.757675
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.757405
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.756598
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.755004
CCSER1 coiled-coil serine-rich protein 1 0.753693
CAMTA1 calmodulin binding transcription activator 1 0.753174
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.75112
CFAP43 cilia and flagella associated protein 43 0.750108
NEGR1 neuronal growth regulator 1 0.747128
DENND4B DENN/MADD domain containing 4B 0.74567
PTPRS protein tyrosine phosphatase, receptor type, S 0.745188
PTPRK protein tyrosine phosphatase, receptor type, K 0.741877
PTCH2 patched 2 0.739121
ESRRG estrogen-related receptor gamma 0.738669
COL13A1 collagen, type XIII, alpha 1 0.738669
TFEC transcription factor EC 0.738669
ASS1 argininosuccinate synthase 1 0.738669
EIF3E eukaryotic translation initiation factor 3, subunit E 0.738669
SEZ6L seizure related 6 homolog (mouse)-like 0.738669
LDB2 LIM domain binding 2 0.738669
C6ORF89 chromosome 6 open reading frame 89 0.738669
NGEF neuronal guanine nucleotide exchange factor 0.738669
SRD5A3 steroid 5 alpha-reductase 3 0.738669
FBLN1 fibulin 1 0.738669
TMEM87A transmembrane protein 87A 0.736216
TSPAN15 tetraspanin 15 0.735265
BRD1 bromodomain containing 1 0.732392
HDAC4 histone deacetylase 4 0.732156
PTPRM protein tyrosine phosphatase, receptor type, M 0.732156
TNIK TRAF2 and NCK interacting kinase 0.73192
LOC344887 NmrA-like family domain containing 1 pseudogene 0.72376
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.721383
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.720957
TBC1D22A TBC1 domain family, member 22A 0.720532
MTUS2 microtubule associated tumor suppressor candidate 2 0.719477
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.719267
CLASP2 cytoplasmic linker associated protein 2 0.71864
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.717397
KIAA1217 KIAA1217 0.716372
LIMCH1 LIM and calponin homology domains 1 0.716372
PRR16 proline rich 16 0.716372
MLPH melanophilin 0.716372
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.716372
KIF13B kinesin family member 13B 0.716372
DOPEY1 dopey family member 1 0.716372
MACROD1 MACRO domain containing 1 0.716372
OSBPL5 oxysterol binding protein-like 5 0.710807
RERG RAS-like, estrogen-regulated, growth inhibitor 0.71042
GATAD2B GATA zinc finger domain containing 2B 0.710228
MIS18BP1 MIS18 binding protein 1 0.710035
ZFPM2 zinc finger protein, FOG family member 2 0.709269
RGS7 regulator of G-protein signaling 7 0.707753
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.707753
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.70719
PPAP2B phosphatidic acid phosphatase type 2B 0.706258
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.702253
AKNAD1 AKNA domain containing 1 0.69773
UMODL1 uromodulin-like 1 0.69773
PCDH15 protocadherin-related 15 0.69773
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.69773
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.69773
LOC339862 uncharacterized LOC339862 0.69773
CADM2 cell adhesion molecule 2 0.69773
FAM71F1 family with sequence similarity 71, member F1 0.69773
SCHIP1 schwannomin interacting protein 1 0.69773
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.69773
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.69773
NAV2 neuron navigator 2 0.695875
PRKCB protein kinase C, beta 0.694217
WDR72 WD repeat domain 72 0.692747
PRKG1 protein kinase, cGMP-dependent, type I 0.692585
DMPK dystrophia myotonica-protein kinase 0.690343
PLD5 phospholipase D family, member 5 0.686457
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.684794
DFNB31 deafness, autosomal recessive 31 0.683452
MRPL47 mitochondrial ribosomal protein L47 0.683009
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.681983
TMEM132D transmembrane protein 132D 0.681983
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.681983
SBF2 SET binding factor 2 0.681983
ASPA aspartoacylase 0.681983
ELOVL6 ELOVL fatty acid elongase 6 0.681983
GLIS3 GLIS family zinc finger 3 0.681983
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.681983
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.681983
NTM neurotrimin 0.681983
LAMA2 laminin, alpha 2 0.681983
LUZP2 leucine zipper protein 2 0.681983
LOC728755 uncharacterized LOC728755 0.681983
ASTN2 astrotactin 2 0.681983
IQCJ IQ motif containing J 0.681983
SMAD7 SMAD family member 7 0.681692
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.680534
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.679533
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.677979
TMEM183A transmembrane protein 183A 0.67576
SPIDR scaffolding protein involved in DNA repair 0.675623
SCLT1 sodium channel and clathrin linker 1 0.67467
SEZ6 seizure related 6 homolog (mouse) 0.674129
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.673994
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.673994
MYO3B myosin IIIB 0.672922
GRM7 glutamate receptor, metabotropic 7 0.672922
ERN2 endoplasmic reticulum to nucleus signaling 2 0.67239
LINC00687 long intergenic non-protein coding RNA 687 0.671336
FAT4 FAT atypical cadherin 4 0.670682
RANBP1 RAN binding protein 1 0.670054
RAD21 RAD21 homolog (S. pombe) 0.669544
CSPP1 centrosome and spindle pole associated protein 1 0.668836
MAN2B2 mannosidase, alpha, class 2B, member 2 0.668836
CLOCK clock circadian regulator 0.668836
CTIF CBP80/20-dependent translation initiation factor 0.668836
THADA thyroid adenoma associated 0.668836
LRP5L low density lipoprotein receptor-related protein 5-like 0.668836
ARHGAP15 Rho GTPase activating protein 15 0.668836
CNTN5 contactin 5 0.668836
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.668836
FAM189A1 family with sequence similarity 189, member A1 0.668836
C4ORF22 chromosome 4 open reading frame 22 0.668836
TOX thymocyte selection-associated high mobility group box 0.668836
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.668836
PARD3B par-3 family cell polarity regulator beta 0.668836
PELP1 proline, glutamate and leucine rich protein 1 0.668836
NUP160 nucleoporin 160kDa 0.668836
C6ORF7 chromosome 6 open reading frame 7 0.668836
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.668836
CCDC174 coiled-coil domain containing 174 0.668836
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.668836
PADI3 peptidyl arginine deiminase, type III 0.668836
CLIC5 chloride intracellular channel 5 0.668836
TMEM165 transmembrane protein 165 0.668836
MACROD2 MACRO domain containing 2 0.668836
SPTBN1 spectrin, beta, non-erythrocytic 1 0.668836
KIAA1456 KIAA1456 0.668836
MINOS1-NBL1 MINOS1-NBL1 readthrough 0.668836
SNAP25 synaptosomal-associated protein, 25kDa 0.668836
FAM163A family with sequence similarity 163, member A 0.668836
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.668836
SGK1 serum/glucocorticoid regulated kinase 1 0.668836
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.668836
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.668836
FGF6 fibroblast growth factor 6 0.668836
CFAP61 cilia and flagella associated protein 61 0.668836
CD38 CD38 molecule 0.668836
SAMD3 sterile alpha motif domain containing 3 0.668836
FAM111B family with sequence similarity 111, member B 0.668836
NXPH1 neurexophilin 1 0.668836
LINC00578 long intergenic non-protein coding RNA 578 0.668836
FRMD6 FERM domain containing 6 0.668836
RELN reelin 0.668836
PDZRN3 PDZ domain containing ring finger 3 0.668836
OSBPL1A oxysterol binding protein-like 1A 0.668836
LYN LYN proto-oncogene, Src family tyrosine kinase 0.668836
KIF16B kinesin family member 16B 0.668836
SCN3A sodium channel, voltage gated, type III alpha subunit 0.668836
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.668836
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.668836
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.668836
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.668836
ATXN1 ataxin 1 0.668836
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.668836
IRAK3 interleukin-1 receptor-associated kinase 3 0.668836
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.668836
SLIT1 slit homolog 1 (Drosophila) 0.668836
DCAF4 DDB1 and CUL4 associated factor 4 0.668836
PDCL2 phosducin-like 2 0.625701
CHD2 chromodomain helicase DNA binding protein 2 0.621951
IKBIP IKBKB interacting protein 0.615118
APAF1 apoptotic peptidase activating factor 1 0.615118
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.605359
ZFYVE1 zinc finger, FYVE domain containing 1 0.60243
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.59964
TCF3 transcription factor 3 0.594024
CACHD1 cache domain containing 1 0.583982
CPM carboxypeptidase M 0.583982
NBEA neurobeachin 0.559045
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.552035
RGS5 regulator of G-protein signaling 5 0.521489