harpagoside-7355 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the harpagoside-7355 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADCK2 aarF domain containing kinase 2
ADM adrenomedullin
AGGF1 angiogenic factor with G patch and FHA domains 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGEL2 angel homolog 2 (Drosophila)
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
AR androgen receptor
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARNT aryl hydrocarbon receptor nuclear translocator
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
B9D2 B9 protein domain 2
BEX4 brain expressed, X-linked 4
BLZF1 basic leucine zipper nuclear factor 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QTNF3 C1q and tumor necrosis factor related protein 3
C9ORF9 chromosome 9 open reading frame 9
CA4 carbonic anhydrase IV
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC28B coiled-coil domain containing 28B
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC14A cell division cycle 14A
CEP85 centrosomal protein 85kDa
CHKB choline kinase beta
COL11A2 collagen, type XI, alpha 2
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
E2F4 E2F transcription factor 4, p107/p130-binding
EEA1 early endosome antigen 1
EXO5 exonuclease 5
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FADS2 fatty acid desaturase 2
FAM188A family with sequence similarity 188, member A
FAM214B family with sequence similarity 214, member B
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GOLGA2 golgin A2
GOSR1 golgi SNAP receptor complex member 1
GOSR2 golgi SNAP receptor complex member 2
GTDC1 glycosyltransferase-like domain containing 1
HFE hemochromatosis
HNMT histamine N-methyltransferase
HOMER3 homer scaffolding protein 3
HPS4 Hermansky-Pudlak syndrome 4
IGHA1 immunoglobulin heavy constant alpha 1
IRS2 insulin receptor substrate 2
ITGB4 integrin, beta 4
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
LIMCH1 LIM and calponin homology domains 1
LOC257152 uncharacterized LOC257152
LRP6 low density lipoprotein receptor-related protein 6
MARK2 MAP/microtubule affinity-regulating kinase 2
MIIP migration and invasion inhibitory protein
MPDZ multiple PDZ domain protein
NADK NAD kinase
NCOA2 nuclear receptor coactivator 2
NUP214 nucleoporin 214kDa
NUP88 nucleoporin 88kDa
PADI1 peptidyl arginine deiminase, type I
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDLIM7 PDZ and LIM domain 7 (enigma)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLIN2 perilipin 2
PLXNA3 plexin A3
POMT2 protein-O-mannosyltransferase 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
RABGAP1L RAB GTPase activating protein 1-like
REPS1 RALBP1 associated Eps domain containing 1
RLN1 relaxin 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SSPN sarcospan
ST20 suppressor of tumorigenicity 20
SYNJ2 synaptojanin 2
TBC1D2 TBC1 domain family, member 2
TBC1D31 TBC1 domain family, member 31
TMPRSS2 transmembrane protease, serine 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TOR1AIP1 torsin A interacting protein 1
TPST1 tyrosylprotein sulfotransferase 1
TRAK1 trafficking protein, kinesin binding 1
TTC30A tetratricopeptide repeat domain 30A
UBE2I ubiquitin-conjugating enzyme E2I
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WAS Wiskott-Aldrich syndrome
XDH xanthine dehydrogenase
ZNF510 zinc finger protein 510
ZNF532 zinc finger protein 532
ZNF609 zinc finger protein 609
ZNF668 zinc finger protein 668
ZNF821 zinc finger protein 821
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABHD14A abhydrolase domain containing 14A
ACTL8 actin-like 8
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
ANKRD36 ankyrin repeat domain 36
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BACE1 beta-site APP-cleaving enzyme 1
BFSP1 beaded filament structural protein 1, filensin
BRPF1 bromodomain and PHD finger containing, 1
C10ORF95 chromosome 10 open reading frame 95
C11ORF80 chromosome 11 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
CCDC85C coiled-coil domain containing 85C
CCNO cyclin O
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CGREF1 cell growth regulator with EF-hand domain 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCF1 cardiotrophin-like cytokine factor 1
CLCN2 chloride channel, voltage-sensitive 2
CLSTN2 calsyntenin 2
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CORT cortistatin
CPPED1 calcineurin-like phosphoesterase domain containing 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DRD1 dopamine receptor D1
DYSF dysferlin
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EPHA2 EPH receptor A2
ERCC4 excision repair cross-complementation group 4
EVPL envoplakin
F3 coagulation factor III (thromboplastin, tissue factor)
FBXO31 F-box protein 31
FKBP10 FK506 binding protein 10, 65 kDa
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPATCH2L G patch domain containing 2-like
GSTA4 glutathione S-transferase alpha 4
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIST1H4F histone cluster 1, H4f
HIST2H2AA3 histone cluster 2, H2aa3
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFI6 interferon, alpha-inducible protein 6
ITPKB inositol-trisphosphate 3-kinase B
KRT15 keratin 15, type I
LHX1 LIM homeobox 1
LIN7B lin-7 homolog B (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
MATK megakaryocyte-associated tyrosine kinase
MCC mutated in colorectal cancers
MOCS3 molybdenum cofactor synthesis 3
NKX3-2 NK3 homeobox 2
NPFFR1 neuropeptide FF receptor 1
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PC pyruvate carboxylase
PCDHB3 protocadherin beta 3
PGBD5 piggyBac transposable element derived 5
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLAT plasminogen activator, tissue
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
RPAP1 RNA polymerase II associated protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SYNC syncoilin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TBX19 T-box 19
TCTN1 tectonic family member 1
TDRD1 tudor domain containing 1
TESC tescalcin
TESPA1 thymocyte expressed, positive selection associated 1
TICAM1 toll-like receptor adaptor molecule 1
TMEM53 transmembrane protein 53
TPRA1 transmembrane protein, adipocyte asscociated 1
TTLL1 tubulin tyrosine ligase-like family member 1
UBQLN4 ubiquilin 4
UPP1 uridine phosphorylase 1
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFC vascular endothelial growth factor C
VIM vimentin
WDR76 WD repeat domain 76
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF141 zinc finger protein 141
ZNF506 zinc finger protein 506
ZNF573 zinc finger protein 573
ZNF606 zinc finger protein 606
ZNF747 zinc finger protein 747
ZSCAN31 zinc finger and SCAN domain containing 31