hand, foot and mouth disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet. (Human Disease Ontology, DOID_10881)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:10881
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Genes

178 genes associated with the disease hand, foot and mouth disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 1.14463
CALCR calcitonin receptor 1.05943
MALRD1 MAM and LDL receptor class A domain containing 1 1.04846
SLC51A solute carrier family 51, alpha subunit 1.02945
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.00596
ZFAND4 zinc finger, AN1-type domain 4 0.989716
CNTNAP2 contactin associated protein-like 2 0.986376
SMAD6 SMAD family member 6 0.971169
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.958374
KLHL32 kelch-like family member 32 0.958374
PTPRJ protein tyrosine phosphatase, receptor type, J 0.958374
TRAPPC9 trafficking protein particle complex 9 0.958374
APP amyloid beta (A4) precursor protein 0.958374
FRMD5 FERM domain containing 5 0.892579
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.886521
EGFR epidermal growth factor receptor 0.88034
C4ORF45 chromosome 4 open reading frame 45 0.88034
AIG1 androgen-induced 1 0.88034
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.88034
C20ORF196 chromosome 20 open reading frame 196 0.88034
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.88034
MAP2 microtubule-associated protein 2 0.88034
RYR2 ryanodine receptor 2 (cardiac) 0.88034
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.88034
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.88034
PXDNL peroxidasin-like 0.831584
CHD9 chromodomain helicase DNA binding protein 9 0.831584
ADAMTSL3 ADAMTS-like 3 0.831584
ERBB4 erb-b2 receptor tyrosine kinase 4 0.831584
PCDH9 protocadherin 9 0.831584
NRXN3 neurexin 3 0.831584
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.831584
ELMO1 engulfment and cell motility 1 0.831584
TPK1 thiamin pyrophosphokinase 1 0.831584
ZNF385D zinc finger protein 385D 0.831584
BMPR1B bone morphogenetic protein receptor, type IB 0.831584
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.831584
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.831584
USP45 ubiquitin specific peptidase 45 0.804621
PAX2 paired box 2 0.801304
FAM207A family with sequence similarity 207, member A 0.79774
CCDC67 coiled-coil domain containing 67 0.794247
FGF12 fibroblast growth factor 12 0.794247
LPA lipoprotein, Lp(a) 0.794247
CADM1 cell adhesion molecule 1 0.794247
NRG3 neuregulin 3 0.794247
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.794247
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.794247
ALPK3 alpha-kinase 3 0.794247
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.794247
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.794247
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.794247
PTPRD protein tyrosine phosphatase, receptor type, D 0.794247
AOX2P aldehyde oxidase 2 pseudogene 0.794247
FRMD4A FERM domain containing 4A 0.764084
LINC00540 long intergenic non-protein coding RNA 540 0.764084
DCLK1 doublecortin-like kinase 1 0.764084
ARMC8 armadillo repeat containing 8 0.764084
MEMO1 mediator of cell motility 1 0.764084
SOX5 SRY (sex determining region Y)-box 5 0.764084
COL13A1 collagen, type XIII, alpha 1 0.738669
TFEC transcription factor EC 0.738669
ESRRG estrogen-related receptor gamma 0.738669
LDB2 LIM domain binding 2 0.738669
C6ORF89 chromosome 6 open reading frame 89 0.738669
NGEF neuronal guanine nucleotide exchange factor 0.738669
FBLN1 fibulin 1 0.738669
SEZ6L seizure related 6 homolog (mouse)-like 0.738669
ASS1 argininosuccinate synthase 1 0.738669
EIF3E eukaryotic translation initiation factor 3, subunit E 0.738669
SRD5A3 steroid 5 alpha-reductase 3 0.738669
TBC1D22A TBC1 domain family, member 22A 0.720532
PRR16 proline rich 16 0.716372
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.716372
DOPEY1 dopey family member 1 0.716372
MACROD1 MACRO domain containing 1 0.716372
MLPH melanophilin 0.716372
LIMCH1 LIM and calponin homology domains 1 0.716372
KIAA1217 KIAA1217 0.716372
KIF13B kinesin family member 13B 0.716372
UMODL1 uromodulin-like 1 0.69773
FAM71F1 family with sequence similarity 71, member F1 0.69773
AKNAD1 AKNA domain containing 1 0.69773
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.69773
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.69773
CADM2 cell adhesion molecule 2 0.69773
LOC339862 uncharacterized LOC339862 0.69773
PCDH15 protocadherin-related 15 0.69773
SCHIP1 schwannomin interacting protein 1 0.69773
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.69773
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.69773
DFNB31 deafness, autosomal recessive 31 0.683452
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.681983
ELOVL6 ELOVL fatty acid elongase 6 0.681983
SBF2 SET binding factor 2 0.681983
TMEM132D transmembrane protein 132D 0.681983
ASPA aspartoacylase 0.681983
GLIS3 GLIS family zinc finger 3 0.681983
IQCJ IQ motif containing J 0.681983
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.681983
LUZP2 leucine zipper protein 2 0.681983
LOC728755 uncharacterized LOC728755 0.681983
ASTN2 astrotactin 2 0.681983
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.681983
LAMA2 laminin, alpha 2 0.681983
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.681983
NTM neurotrimin 0.681983
SAMD3 sterile alpha motif domain containing 3 0.668836
CFAP61 cilia and flagella associated protein 61 0.668836
FRMD6 FERM domain containing 6 0.668836
SGK1 serum/glucocorticoid regulated kinase 1 0.668836
FAM111B family with sequence similarity 111, member B 0.668836
LINC00578 long intergenic non-protein coding RNA 578 0.668836
KIF16B kinesin family member 16B 0.668836
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.668836
RELN reelin 0.668836
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.668836
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.668836
TMEM165 transmembrane protein 165 0.668836
MACROD2 MACRO domain containing 2 0.668836
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.668836
KIAA1456 KIAA1456 0.668836
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.668836
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.668836
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.668836
CLOCK clock circadian regulator 0.668836
C6ORF7 chromosome 6 open reading frame 7 0.668836
LYN LYN proto-oncogene, Src family tyrosine kinase 0.668836
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.668836
CNTN5 contactin 5 0.668836
ARHGAP15 Rho GTPase activating protein 15 0.668836
TOX thymocyte selection-associated high mobility group box 0.668836
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.668836
CCDC174 coiled-coil domain containing 174 0.668836
PARD3B par-3 family cell polarity regulator beta 0.668836
PELP1 proline, glutamate and leucine rich protein 1 0.668836
FAM189A1 family with sequence similarity 189, member A1 0.668836
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.668836
SPTBN1 spectrin, beta, non-erythrocytic 1 0.668836
LRP5L low density lipoprotein receptor-related protein 5-like 0.668836
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.668836
CSPP1 centrosome and spindle pole associated protein 1 0.668836
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.668836
FGF6 fibroblast growth factor 6 0.668836
CTIF CBP80/20-dependent translation initiation factor 0.668836
CD38 CD38 molecule 0.668836
SLIT1 slit homolog 1 (Drosophila) 0.668836
MAN2B2 mannosidase, alpha, class 2B, member 2 0.668836
C4ORF22 chromosome 4 open reading frame 22 0.668836
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.668836
PADI3 peptidyl arginine deiminase, type III 0.668836
NUP160 nucleoporin 160kDa 0.668836
CLIC5 chloride intracellular channel 5 0.668836
SNAP25 synaptosomal-associated protein, 25kDa 0.668836
PDZRN3 PDZ domain containing ring finger 3 0.668836
MINOS1-NBL1 MINOS1-NBL1 readthrough 0.668836
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.668836
OSBPL1A oxysterol binding protein-like 1A 0.668836
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.668836
SCN3A sodium channel, voltage gated, type III alpha subunit 0.668836
NXPH1 neurexophilin 1 0.668836
DCAF4 DDB1 and CUL4 associated factor 4 0.668836
ATXN1 ataxin 1 0.668836
IRAK3 interleukin-1 receptor-associated kinase 3 0.668836
THADA thyroid adenoma associated 0.668836
FAM163A family with sequence similarity 163, member A 0.668836
PDCL2 phosducin-like 2 0.625701
CHD2 chromodomain helicase DNA binding protein 2 0.621951
APAF1 apoptotic peptidase activating factor 1 0.615118
IKBIP IKBKB interacting protein 0.615118
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.605359
ZFYVE1 zinc finger, FYVE domain containing 1 0.60243
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.59964
TCF3 transcription factor 3 0.594024
CPM carboxypeptidase M 0.583982
CACHD1 cache domain containing 1 0.583982
NBEA neurobeachin 0.559045
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.552035