guanyl-nucleotide exchange factor activity Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. (Gene Ontology, GO_0005085)
External Link http://amigo.geneontology.org/amigo/term/GO:0005085
Similar Terms
Downloads & Tools

Genes

192 genes performing the guanyl-nucleotide exchange factor activity molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
ABR active BCR-related
ADRB1 adrenoceptor beta 1
AKAP13 A kinase (PRKA) anchor protein 13
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ALS2CL ALS2 C-terminal like
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARFGEF3 ARFGEF family member 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
BCAR3 breast cancer anti-estrogen resistance 3
BCR breakpoint cluster region
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
CYTH4 cytohesin 4
DENND1A DENN/MADD domain containing 1A
DENND1B DENN/MADD domain containing 1B
DENND1C DENN/MADD domain containing 1C
DENND2A DENN/MADD domain containing 2A
DENND2C DENN/MADD domain containing 2C
DENND2D DENN/MADD domain containing 2D
DENND3 DENN/MADD domain containing 3
DENND4A DENN/MADD domain containing 4A
DENND4B DENN/MADD domain containing 4B
DENND4C DENN/MADD domain containing 4C
DENND5A DENN/MADD domain containing 5A
DENND5B DENN/MADD domain containing 5B
DENND6A DENN/MADD domain containing 6A
DENND6B DENN/MADD domain containing 6B
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DNMBP dynamin binding protein
DOCK1 dedicator of cytokinesis 1
DOCK10 dedicator of cytokinesis 10
DOCK11 dedicator of cytokinesis 11
DOCK2 dedicator of cytokinesis 2
DOCK3 dedicator of cytokinesis 3
DOCK4 dedicator of cytokinesis 4
DOCK5 dedicator of cytokinesis 5
DOCK6 dedicator of cytokinesis 6
DOCK7 dedicator of cytokinesis 7
DOCK8 dedicator of cytokinesis 8
DOCK9 dedicator of cytokinesis 9
ECT2 epithelial cell transforming 2
ECT2L epithelial cell transforming 2 like
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EPS8L1 EPS8-like 1
EPS8L2 EPS8-like 2
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO8 F-box protein 8
FFAR1 free fatty acid receptor 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FGD5 FYVE, RhoGEF and PH domain containing 5
FGD6 FYVE, RhoGEF and PH domain containing 6
FNIP1 folliculin interacting protein 1
GAPVD1 GTPase activating protein and VPS9 domains 1
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GCGR glucagon receptor
GDPGP1 GDP-D-glucose phosphorylase 1
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
IQSEC1 IQ motif and Sec7 domain 1
IQSEC2 IQ motif and Sec7 domain 2
IQSEC3 IQ motif and Sec7 domain 3
ITSN1 intersectin 1 (SH3 domain protein)
ITSN2 intersectin 2
KALRN kalirin, RhoGEF kinase
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MADD MAP-kinase activating death domain
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MCF2L2 MCF.2 cell line derived transforming sequence-like 2
MON2 MON2 homolog (S. cerevisiae)
NET1 neuroepithelial cell transforming 1
NGEF neuronal guanine nucleotide exchange factor
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PCP2 Purkinje cell protein 2
PLCE1 phospholipase C, epsilon 1
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PSD pleckstrin and Sec7 domain containing
PSD2 pleckstrin and Sec7 domain containing 2
PSD3 pleckstrin and Sec7 domain containing 3
PSD4 pleckstrin and Sec7 domain containing 4
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB3IP RAB3A interacting protein
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RABIF RAB interacting factor
RALGDS ral guanine nucleotide dissociation stimulator
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RANBP10 RAN binding protein 10
RANGRF RAN guanine nucleotide release factor
RAP1A RAP1A, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGEF1A RasGEF domain family, member 1A
RASGEF1B RasGEF domain family, member 1B
RASGEF1C RasGEF domain family, member 1C
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASGRP4 RAS guanyl releasing protein 4
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RCC1 regulator of chromosome condensation 1
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RGL3 ral guanine nucleotide dissociation stimulator-like 3
RGL4 ral guanine nucleotide dissociation stimulator-like 4
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RIC1 RAB6A GEF complex partner 1
RIC8A RIC8 guanine nucleotide exchange factor A
RIC8B RIC8 guanine nucleotide exchange factor B
RIN2 Ras and Rab interactor 2
RIN3 Ras and Rab interactor 3
RINL Ras and Rab interactor-like
RPGR retinitis pigmentosa GTPase regulator
SBF1 SET binding factor 1
SBF2 SET binding factor 2
SERGEF secretion regulating guanine nucleotide exchange factor
SH2D3A SH2 domain containing 3A
SH2D3C SH2 domain containing 3C
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPATA13 spermatogenesis associated 13
ST5 suppression of tumorigenicity 5
TAGAP T-cell activation RhoGTPase activating protein
TBC1D10A TBC1 domain family, member 10A
TBXA2R thromboxane A2 receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TRAPPC1 trafficking protein particle complex 1
TRAPPC4 trafficking protein particle complex 4
TRIO trio Rho guanine nucleotide exchange factor
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor