guanfacine-4660 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the guanfacine-4660 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APOD apolipoprotein D
ARHGAP35 Rho GTPase activating protein 35
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BAAT bile acid CoA:amino acid N-acyltransferase
BBS9 Bardet-Biedl syndrome 9
BMP8A bone morphogenetic protein 8a
C2CD2L C2CD2-like
CADM4 cell adhesion molecule 4
CC2D1A coiled-coil and C2 domain containing 1A
CD58 CD58 molecule
CDK13 cyclin-dependent kinase 13
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CXCR4 chemokine (C-X-C motif) receptor 4
DCTN2 dynactin 2 (p50)
DIO3 deiodinase, iodothyronine, type III
DOCK6 dedicator of cytokinesis 6
DOHH deoxyhypusine hydroxylase/monooxygenase
DPF1 D4, zinc and double PHD fingers family 1
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EDIL3 EGF-like repeats and discoidin I-like domains 3
EML3 echinoderm microtubule associated protein like 3
ENG endoglin
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ESRRG estrogen-related receptor gamma
FBXO22 F-box protein 22
FETUB fetuin B
FGFR1 fibroblast growth factor receptor 1
FILIP1L filamin A interacting protein 1-like
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAS2L1 growth arrest-specific 2 like 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
HCG9 HLA complex group 9 (non-protein coding)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFFO1 intermediate filament family orphan 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL2 interleukin 2
KCTD13 potassium channel tetramerization domain containing 13
KRT6B keratin 6B, type II
LARP7 La ribonucleoprotein domain family, member 7
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMD2 LIM domain containing 2
LIPG lipase, endothelial
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP2K7 mitogen-activated protein kinase kinase 7
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIIP migration and invasion inhibitory protein
MRAS muscle RAS oncogene homolog
MST1 macrophage stimulating 1
MUC4 mucin 4, cell surface associated
MYH14 myosin, heavy chain 14, non-muscle
NAAA N-acylethanolamine acid amidase
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCF4 neutrophil cytosolic factor 4, 40kDa
NIPAL2 NIPA-like domain containing 2
NTS neurotensin
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OGFR opioid growth factor receptor
ONECUT2 one cut homeobox 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PEX6 peroxisomal biogenesis factor 6
PLXNB3 plexin B3
POU1F1 POU class 1 homeobox 1
PRAMEF12 PRAME family member 12
PRPH peripherin
PTBP3 polypyrimidine tract binding protein 3
PTGDR2 prostaglandin D2 receptor 2
RABGAP1 RAB GTPase activating protein 1
RFXAP regulatory factor X-associated protein
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS14 ribosomal protein S14
RPS3A ribosomal protein S3A
SCAPER S-phase cyclin A-associated protein in the ER
SLA Src-like-adaptor
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMG6 SMG6 nonsense mediated mRNA decay factor
SNN stannin
SNTG1 syntrophin, gamma 1
SPI1 Spi-1 proto-oncogene
STS steroid sulfatase (microsomal), isozyme S
STX7 syntaxin 7
SULF1 sulfatase 1
TBX1 T-box 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
XDH xanthine dehydrogenase
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZNF214 zinc finger protein 214
ZNF34 zinc finger protein 34
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACKR3 atypical chemokine receptor 3
AGO4 argonaute RISC catalytic component 4
ALPK1 alpha-kinase 1
APOL6 apolipoprotein L, 6
ATAD5 ATPase family, AAA domain containing 5
BIK BCL2-interacting killer (apoptosis-inducing)
C14ORF105 chromosome 14 open reading frame 105
CA11 carbonic anhydrase XI
CAMKMT calmodulin-lysine N-methyltransferase
CCNJ cyclin J
CD101 CD101 molecule
CLDN1 claudin 1
CLEC16A C-type lectin domain family 16, member A
CNTLN centlein, centrosomal protein
CORO1A coronin, actin binding protein, 1A
CREB5 cAMP responsive element binding protein 5
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
EAF2 ELL associated factor 2
ELP3 elongator acetyltransferase complex subunit 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM110B family with sequence similarity 110, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FKBP5 FK506 binding protein 5
FRMPD1 FERM and PDZ domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GEMIN8 gem (nuclear organelle) associated protein 8
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR1 G protein-coupled receptor 1
GREB1L growth regulation by estrogen in breast cancer-like
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HIST1H4E histone cluster 1, H4e
HOXA4 homeobox A4
IL32 interleukin 32
INADL InaD-like (Drosophila)
IRAK4 interleukin-1 receptor-associated kinase 4
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM8 lysine (K)-specific demethylase 8
KIAA0753 KIAA0753
KLHL28 kelch-like family member 28
LOC157562 uncharacterized LOC157562
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRP3 low density lipoprotein receptor-related protein 3
LRRK1 leucine-rich repeat kinase 1
LTC4S leukotriene C4 synthase
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MBIP MAP3K12 binding inhibitory protein 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MEIS1 Meis homeobox 1
METTL1 methyltransferase like 1
METTL16 methyltransferase like 16
MFSD6 major facilitator superfamily domain containing 6
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NPM3 nucleophosmin/nucleoplasmin 3
OCA2 oculocutaneous albinism II
PARM1 prostate androgen-regulated mucin-like protein 1
PDGFRL platelet-derived growth factor receptor-like
PTK6 protein tyrosine kinase 6
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
PWAR5 Prader Willi/Angelman region RNA 5
R3HCC1L R3H domain and coiled-coil containing 1-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RGS17 regulator of G-protein signaling 17
RNF2 ring finger protein 2
SAMD9 sterile alpha motif domain containing 9
SCG5 secretogranin V
SCIN scinderin
SCN9A sodium channel, voltage gated, type IX alpha subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SH2D2A SH2 domain containing 2A
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SNHG3 small nucleolar RNA host gene 3
SPATA1 spermatogenesis associated 1
SRD5A3 steroid 5 alpha-reductase 3
STAB2 stabilin 2
STEAP4 STEAP family member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM209 transmembrane protein 209
TRAPPC13 trafficking protein particle complex 13
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSC22D4 TSC22 domain family, member 4
ZFYVE16 zinc finger, FYVE domain containing 16
ZNF10 zinc finger protein 10
ZNF124 zinc finger protein 124
ZNF480 zinc finger protein 480
ZNF671 zinc finger protein 671