guaifenesin-4549 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the guaifenesin-4549 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADGRL4 adhesion G protein-coupled receptor L4
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATXN3L ataxin 3-like
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C14ORF105 chromosome 14 open reading frame 105
C17ORF53 chromosome 17 open reading frame 53
C20ORF195 chromosome 20 open reading frame 195
C6ORF10 chromosome 6 open reading frame 10
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCL27 chemokine (C-C motif) ligand 27
CD33 CD33 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CDK13 cyclin-dependent kinase 13
CDON cell adhesion associated, oncogene regulated
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPO centromere protein O
CLCN6 chloride channel, voltage-sensitive 6
CLEC11A C-type lectin domain family 11, member A
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DCN decorin
DGCR2 DiGeorge syndrome critical region gene 2
DKKL1 dickkopf-like 1
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DSTYK dual serine/threonine and tyrosine protein kinase
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FGF1 fibroblast growth factor 1 (acidic)
FRMPD1 FERM and PDZ domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
FYB FYN binding protein
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRIP2 glutamate receptor interacting protein 2
GSTA1 glutathione S-transferase alpha 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXD3 homeobox D3
IFNA14 interferon, alpha 14
IFNA17 interferon, alpha 17
IL36RN interleukin 36 receptor antagonist
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
LEFTY2 left-right determination factor 2
LIG4 ligase IV, DNA, ATP-dependent
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRC2 leucine rich repeat containing 2
LRRN3 leucine rich repeat neuronal 3
LTBP4 latent transforming growth factor beta binding protein 4
MAP2K7 mitogen-activated protein kinase kinase 7
MASP2 mannan-binding lectin serine peptidase 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MEGF9 multiple EGF-like-domains 9
MUC8 mucin 8
MVB12B multivesicular body subunit 12B
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NLGN1 neuroligin 1
NPR1 natriuretic peptide receptor 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
ONECUT2 one cut homeobox 2
OPRL1 opiate receptor-like 1
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PAX1 paired box 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDLIM7 PDZ and LIM domain 7 (enigma)
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRB1 proline-rich protein BstNI subfamily 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PSG1 pregnancy specific beta-1-glycoprotein 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RDH5 retinol dehydrogenase 5 (11-cis/9-cis)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF126P1 ring finger protein 126 pseudogene 1
SCAND2P SCAN domain containing 2 pseudogene
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SLIT3 slit homolog 3 (Drosophila)
SORBS2 sorbin and SH3 domain containing 2
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TPM1 tropomyosin 1 (alpha)
TRD T cell receptor delta locus
TRIM10 tripartite motif containing 10
TTC12 tetratricopeptide repeat domain 12
VGF VGF nerve growth factor inducible
VNN2 vanin 2

decreased expression

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ADCY6 adenylate cyclase 6
AFAP1 actin filament associated protein 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARHGAP12 Rho GTPase activating protein 12
ARMC6 armadillo repeat containing 6
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAG4 BCL2-associated athanogene 4
BEX4 brain expressed, X-linked 4
C1RL complement component 1, r subcomponent-like
C22ORF29 chromosome 22 open reading frame 29
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC68 coiled-coil domain containing 68
CDC37L1 cell division cycle 37-like 1
CLASP1 cytoplasmic linker associated protein 1
CLSPN claspin
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
COPS7B COP9 signalosome subunit 7B
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPNE7 copine VII
CTC1 CTS telomere maintenance complex component 1
CTSF cathepsin F
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYBRD1 cytochrome b reductase 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
FADS2 fatty acid desaturase 2
FANCC Fanconi anemia, complementation group C
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FMO4 flavin containing monooxygenase 4
FOXC1 forkhead box C1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAS8 growth arrest-specific 8
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2IRD1 GTF2I repeat domain containing 1
HIST1H3G histone cluster 1, H3g
HOXA6 homeobox A6
IFI30 interferon, gamma-inducible protein 30
IFI44L interferon-induced protein 44-like
IL17RA interleukin 17 receptor A
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLK5 kallikrein-related peptidase 5
LRP3 low density lipoprotein receptor-related protein 3
LRRC16A leucine rich repeat containing 16A
MCC mutated in colorectal cancers
MFSD6 major facilitator superfamily domain containing 6
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOTCH1 notch 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NT5M 5',3'-nucleotidase, mitochondrial
OLFML2A olfactomedin-like 2A
OSBP2 oxysterol binding protein 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PAIP2B poly(A) binding protein interacting protein 2B
PER3 period circadian clock 3
PID1 phosphotyrosine interaction domain containing 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PORCN porcupine homolog (Drosophila)
PRSS53 protease, serine, 53
PRSS8 protease, serine, 8
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK7 protein tyrosine kinase 7 (inactive)
QTRT1 queuine tRNA-ribosyltransferase 1
RAB25 RAB25, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RAD51AP1 RAD51 associated protein 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
SALL2 spalt-like transcription factor 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SH2D4A SH2 domain containing 4A
SLITRK5 SLIT and NTRK-like family, member 5
SMG9 SMG9 nonsense mediated mRNA decay factor
SOAT1 sterol O-acyltransferase 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
THOC6 THO complex 6
TMSB15A thymosin beta 15a
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TOR4A torsin family 4, member A
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBG2 tubulin, gamma 2
USP18 ubiquitin specific peptidase 18
USP19 ubiquitin specific peptidase 19
USP6NL USP6 N-terminal like
WDR19 WD repeat domain 19
YOD1 YOD1 deubiquitinase
YPEL1 yippee-like 1 (Drosophila)
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF37BP zinc finger protein 37B, pseudogene
ZNF623 zinc finger protein 623
ZNF747 zinc finger protein 747