guaifenesin-4371 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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195 genes differentially expressed following the guaifenesin-4371 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ANGPT4 angiopoietin 4
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP11A ATPase, class VI, type 11A
BAX BCL2-associated X protein
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BST2 bone marrow stromal cell antigen 2
C11ORF30 chromosome 11 open reading frame 30
C17ORF53 chromosome 17 open reading frame 53
C3 complement component 3
CALCR calcitonin receptor
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CDH18 cadherin 18, type 2
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CLCA1 chloride channel accessory 1
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CYSLTR2 cysteinyl leukotriene receptor 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELOVL5 ELOVL fatty acid elongase 5
EPHA5 EPH receptor A5
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FAM49A family with sequence similarity 49, member A
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GK glycerol kinase
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
GPER1 G protein-coupled estrogen receptor 1
GSK3A glycogen synthase kinase 3 alpha
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIRA histone cell cycle regulator
IDS iduronate 2-sulfatase
IFNA17 interferon, alpha 17
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INTS1 integrator complex subunit 1
ITGA9 integrin, alpha 9
ITGB7 integrin, beta 7
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KCTD17 potassium channel tetramerization domain containing 17
KDM4B lysine (K)-specific demethylase 4B
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
LMNB1 lamin B1
LTBP4 latent transforming growth factor beta binding protein 4
MAPK7 mitogen-activated protein kinase 7
MAU2 MAU2 sister chromatid cohesion factor
MBD2 methyl-CpG binding domain protein 2
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MIA melanoma inhibitory activity
MIER2 mesoderm induction early response 1, family member 2
MST1 macrophage stimulating 1
MUC3B mucin 3B, cell surface associated
MXD4 MAX dimerization protein 4
NOD2 nucleotide-binding oligomerization domain containing 2
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OR10J1 olfactory receptor, family 10, subfamily J, member 1
PAX5 paired box 5
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE10A phosphodiesterase 10A
PGR progesterone receptor
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POF1B premature ovarian failure, 1B
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PVT1 Pvt1 oncogene (non-protein coding)
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPL3L ribosomal protein L3-like
S100A1 S100 calcium binding protein A1
SCAND2P SCAN domain containing 2 pseudogene
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
SHOX2 short stature homeobox 2
SIM2 single-minded family bHLH transcription factor 2
SLC16A4 solute carrier family 16, member 4
SLC39A9 solute carrier family 39, member 9
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLURP1 secreted LY6/PLAUR domain containing 1
SNAP25 synaptosomal-associated protein, 25kDa
SNX13 sorting nexin 13
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SSX1 synovial sarcoma, X breakpoint 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBX3 T-box 3
TNC tenascin C
TRIM10 tripartite motif containing 10
TRIM17 tripartite motif containing 17
TRIM36 tripartite motif containing 36
TRIO trio Rho guanine nucleotide exchange factor
TSPAN32 tetraspanin 32
TTC39A tetratricopeptide repeat domain 39A
UTS2 urotensin 2
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFP64 ZFP64 zinc finger protein
ZFYVE9 zinc finger, FYVE domain containing 9
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
AFF4 AF4/FMR2 family, member 4
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMT aminomethyltransferase
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APLP1 amyloid beta (A4) precursor-like protein 1
ASIC3 acid sensing (proton gated) ion channel 3
BIRC7 baculoviral IAP repeat containing 7
C1ORF105 chromosome 1 open reading frame 105
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCDC134 coiled-coil domain containing 134
CCDC68 coiled-coil domain containing 68
CD83 CD83 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK20 cyclin-dependent kinase 20
CDK3 cyclin-dependent kinase 3
CNTFR ciliary neurotrophic factor receptor
CRLF1 cytokine receptor-like factor 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DAGLA diacylglycerol lipase, alpha
DNAH17 dynein, axonemal, heavy chain 17
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNASE1L2 deoxyribonuclease I-like 2
EGR3 early growth response 3
EPHA2 EPH receptor A2
F2R coagulation factor II (thrombin) receptor
FAM155A family with sequence similarity 155, member A
FAM184A family with sequence similarity 184, member A
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FKBP5 FK506 binding protein 5
FKRP fukutin related protein
FOSL1 FOS-like antigen 1
FOXN2 forkhead box N2
FSHB follicle stimulating hormone, beta polypeptide
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAMT guanidinoacetate N-methyltransferase
GATA4 GATA binding protein 4
GJA9 gap junction protein, alpha 9, 59kDa
GMPR guanosine monophosphate reductase
GPR39 G protein-coupled receptor 39
GSTP1 glutathione S-transferase pi 1
H2AFY2 H2A histone family, member Y2
HIST1H2AI histone cluster 1, H2ai
HOXC4 homeobox C4
IDI2-AS1 IDI2 antisense RNA 1
KIAA0754 KIAA0754
KIFC3 kinesin family member C3
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL25 kelch-like family member 25
KREMEN2 kringle containing transmembrane protein 2
KRT6B keratin 6B, type II
LGALS9 lectin, galactoside-binding, soluble, 9
LRRTM2 leucine rich repeat transmembrane neuronal 2
LTBP2 latent transforming growth factor beta binding protein 2
MAL mal, T-cell differentiation protein
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK10 mitogen-activated protein kinase 10
MCOLN3 mucolipin 3
MED31 mediator complex subunit 31
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NLRX1 NLR family member X1
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE12 phosphodiesterase 12
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
POLM polymerase (DNA directed), mu
PRF1 perforin 1 (pore forming protein)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTPRE protein tyrosine phosphatase, receptor type, E
RAB3D RAB3D, member RAS oncogene family
RFPL1S RFPL1 antisense RNA 1
RFXAP regulatory factor X-associated protein
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
S100A7 S100 calcium binding protein A7
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLMO1 slowmo homolog 1 (Drosophila)
SNTA1 syntrophin, alpha 1
TRIM21 tripartite motif containing 21
USP27X ubiquitin specific peptidase 27, X-linked
VEGFB vascular endothelial growth factor B
VIPR1 vasoactive intestinal peptide receptor 1
WFDC2 WAP four-disulfide core domain 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF37BP zinc finger protein 37B, pseudogene
ZNF41 zinc finger protein 41
ZNF492 zinc finger protein 492
ZNF506 zinc finger protein 506
ZNF532 zinc finger protein 532
ZNF639 zinc finger protein 639
ZNF750 zinc finger protein 750