gramine-3999 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the gramine-3999 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACVR1B activin A receptor, type IB
ANP32A-IT1 ANP32A intronic transcript 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AREG amphiregulin
ASAP1-IT1 ASAP1 intronic transcript 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
AURKA aurora kinase A
BAIAP3 BAI1-associated protein 3
BTBD18 BTB (POZ) domain containing 18
CCDC9 coiled-coil domain containing 9
CD2 CD2 molecule
CD27 CD27 molecule
CDC42 cell division cycle 42
CDH5 cadherin 5, type 2 (vascular endothelium)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP295 centrosomal protein 295kDa
CFDP1 craniofacial development protein 1
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CST1 cystatin SN
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DPY19L1 dpy-19-like 1 (C. elegans)
EXOC7 exocyst complex component 7
FBXO40 F-box protein 40
FGF1 fibroblast growth factor 1 (acidic)
FLT1 fms-related tyrosine kinase 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAL3ST4 galactose-3-O-sulfotransferase 4
GSTCD glutathione S-transferase, C-terminal domain containing
HGD homogentisate 1,2-dioxygenase
HOXD13 homeobox D13
IFNA8 interferon, alpha 8
IL11 interleukin 11
KIF13A kinesin family member 13A
KISS1 KiSS-1 metastasis-suppressor
KLK12 kallikrein-related peptidase 12
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LARP7 La ribonucleoprotein domain family, member 7
LOXL3 lysyl oxidase-like 3
LRRC40 leucine rich repeat containing 40
LTB4R leukotriene B4 receptor
MAGEA5 melanoma antigen family A5
MAP2K5 mitogen-activated protein kinase kinase 5
MARS methionyl-tRNA synthetase
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MATN3 matrilin 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MRAS muscle RAS oncogene homolog
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFX1 nuclear transcription factor, X-box binding 1
NPFF neuropeptide FF-amide peptide precursor
NRP2 neuropilin 2
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)
PCDH1 protocadherin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PGM5 phosphoglucomutase 5
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
POU2F2 POU class 2 homeobox 2
PPIA peptidylprolyl isomerase A (cyclophilin A)
RABGAP1 RAB GTPase activating protein 1
RHOBTB3 Rho-related BTB domain containing 3
RNASEH2B ribonuclease H2, subunit B
RPL10L ribosomal protein L10-like
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
SAA3P serum amyloid A3 pseudogene
SCAF4 SR-related CTD-associated factor 4
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SGSM2 small G protein signaling modulator 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SMAD4 SMAD family member 4
SMPX small muscle protein, X-linked
SPANXC SPANX family, member C
SSTR2 somatostatin receptor 2
TBC1D2 TBC1 domain family, member 2
TBRG4 transforming growth factor beta regulator 4
TCEAL2 transcription elongation factor A (SII)-like 2
THBD thrombomodulin
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TJP3 tight junction protein 3
TLX2 T-cell leukemia homeobox 2
TM2D1 TM2 domain containing 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TTC9 tetratricopeptide repeat domain 9
USP29 ubiquitin specific peptidase 29
VGF VGF nerve growth factor inducible
VIPR2 vasoactive intestinal peptide receptor 2
WNK1 WNK lysine deficient protein kinase 1
ZCCHC11 zinc finger, CCHC domain containing 11
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ALOX15B arachidonate 15-lipoxygenase, type B
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP22 Rho GTPase activating protein 22
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARMCX4 armadillo repeat containing, X-linked 4
ATXN2 ataxin 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B9D2 B9 protein domain 2
BFSP1 beaded filament structural protein 1, filensin
BST1 bone marrow stromal cell antigen 1
C17ORF53 chromosome 17 open reading frame 53
C5ORF45 chromosome 5 open reading frame 45
CBX8 chromobox homolog 8
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CINP cyclin-dependent kinase 2 interacting protein
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNGB3 cyclic nucleotide gated channel beta 3
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DMTN dematin actin binding protein
DNAL4 dynein, axonemal, light chain 4
EFNB1 ephrin-B1
EMP3 epithelial membrane protein 3
EPN1 epsin 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXL15 F-box and leucine-rich repeat protein 15
FBXO2 F-box protein 2
FRS3 fibroblast growth factor receptor substrate 3
GJA9 gap junction protein, alpha 9, 59kDa
GNL1 guanine nucleotide binding protein-like 1
HHAT hedgehog acyltransferase
HSF2BP heat shock transcription factor 2 binding protein
IFI6 interferon, alpha-inducible protein 6
IFNA14 interferon, alpha 14
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL12RB1 interleukin 12 receptor, beta 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITPKA inositol-trisphosphate 3-kinase A
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KLHL36 kelch-like family member 36
KRT33A keratin 33A, type I
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYPD3 LY6/PLAUR domain containing 3
MANBA mannosidase, beta A, lysosomal
MMP10 matrix metallopeptidase 10
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NLGN1 neuroligin 1
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ONECUT2 one cut homeobox 2
ORC1 origin recognition complex, subunit 1
PALMD palmdelphin
PAX9 paired box 9
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP prolactin-induced protein
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POLH polymerase (DNA directed), eta
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PTGES2 prostaglandin E synthase 2
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGCC regulator of cell cycle
RNF126P1 ring finger protein 126 pseudogene 1
RNF2 ring finger protein 2
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A3 S100 calcium binding protein A3
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLAMF7 SLAM family member 7
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SSTR4 somatostatin receptor 4
SUGP1 SURP and G patch domain containing 1
TAGLN3 transgelin 3
TESPA1 thymocyte expressed, positive selection associated 1
TEX40 testis expressed 40
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIMP4 TIMP metallopeptidase inhibitor 4
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNNI3 troponin I type 3 (cardiac)
TRABD TraB domain containing
TSNAXIP1 translin-associated factor X interacting protein 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
WDR25 WD repeat domain 25
WFDC2 WAP four-disulfide core domain 2
ZFHX3 zinc finger homeobox 3
ZNF205 zinc finger protein 205
ZNF268 zinc finger protein 268
ZNF358 zinc finger protein 358
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816